Heavy metal toxicity has proven to be a major threat and there are several health risks associated with it. The toxic effects of these metals, even though they do not have any biological role, remain present in some or the other form harmful for the human body and its proper functioning. They sometimes act as a pseudo element of the body while at certain times they may even interfere with metabolic processes. Few metals, such as aluminium, can be removed through elimination activities, while some metals get accumulated in the body and food chain, exhibiting a chronic nature. Various public health measures have been undertaken to control, prevent and treat metal toxicity occurring at various levels, such as occupational exposure, accidents and environmental factors. Metal toxicity depends upon the absorbed dose, the route of exposure and duration of exposure, i.e. acute or chronic. This can lead to various disorders and can also result in excessive damage due to oxidative stress induced by free radical formation. This review gives details about some heavy metals and their toxicity mechanisms, along with their health effects
Abate E, Hussien S, Laing M, Mengistu F. (2013). Aluminium toxicity tolerance in cereals: Mechanisms, genetic control and breeding methods. Afr J Agric Res 8(9): 711-722.
Agency for Toxic Substances and Disease Registry (2008). Public Health Statement Aluminium. ATSDR Publication CAS#7429-90-5.
Albretsen J. (2006). The toxicity of iron, an essential element. Veterinary medicine 82-90.
Alina M, Azrina A, Mohd Yunus AS, Mohd Zakiuddin S, Mohd Izuan Eff endi H, Muhammad Rizal R. (2012). Heavy metals (mercury, arsenic, cadmium, plumbum) in selected marine fish and shellfish along the Straits of Malacca. Int Food Res J 19(1): 135-140.
Andia JB. (1996). Aluminum toxicity: its relationship with bone and iron metabolism. Nephrol Dial Transplant 11 Suppl 3: 69-73.
Ashe WF, Largent EJ, Dutra FR, Hubbard DM, Blackstone M. (1953). Behavior of mercury in the animal organism following inhalation. AMA Arch Ind Hyg Occup Med 7(1): 19-43.
Barabasz W, Albinska D, Jaskowska M, Lipiec J. (2002). Ecotoxicology of Aluminium. Pol J Environ Stud 11(3): 199-203.
Becker M, Asch F. (2005). Iron toxicity in rice - conditions and management concepts. J Plant Nutr Soil Sci 168: 559-553.
Bernard A. (2008). Cadmium & its adverse eff ects on human health. Indian J Med Res 128(4): 557-64.
Bezak-Mazur E, Widiak M, Ciupa T. (2001). A speciation analysis of aluminium in the River Silnica. Pol J Environ Stud 10(4): 263-268.
Bhasin G, Kauser H, Athar M. (2002). Iron augments stage-I and stage-II tumor promotion in murine skin. Cancer Lett 183(2): 113-122.
Bielicka A, Bojanowska I, Wisniewski A. (2005). Two Faces of Chromium-Pollutant and Bioelement. Pol J Environ Stud 14(1): 5-10.
Brochin R, Leone S, Phillips D, Shepard N, Zisa D, Angerio A. (2008). The cellular eff ect of lead poisoning and its clinical picture. GUJHS. 5(2): 1-8.
Castagnetto JM, Hennessy SW, Roberts VA, Getzoff ED, Tainer JA, Pique ME. (2002). MDB: the metalloprotein database and browser at the Scripps Research Institute. Nucleic Acids Res 30(1): 379-382.
Cervantes C, Campos-Garcia J, Devars S, Gutierrez‐Corona F, Loza‐Tavera H, Torres‐Guzman JC, Moreno‐Sanchez R. (2001). Interactions of chromium with microorganisms and plants. FEMS Microbiol Rev 25(3): 335-347.
Chakraborty S, Dutta AR, Sural S, Gupta D, Sen S. (2013). Ailing bones and failing kidneys: a case of chronic cadmium toxicity. Ann Clin Biochem 50(5): 492-495.
Chandra P, Kulshreshtha K. (2004). Chromium accumulation and toxicity in aquatic vascular plants. Botanical Rev 70(3): 313-327.
Chen CW, Chen CF, Dong CD. (2012). Distribution and Accumulation of Mercury in Sediments of Kaohsiung River Mouth, Taiwan. APCBEE Procedia 1: 153-158.
Chowdhury UK, Biswas BK, Chowdhury TR, Samanta G, Mandal BK, Basu GC, Chakraborti D. (2000). Groundwater arsenic contamination in Bangladesh and West Bengal, India. Environ Health Perspect 108(5): 393-397.
Clayton DB. (1989). Water pollution at Lowermoore North Cornwall: Report of the Lowermoore incident health advisory committee. Truro, Cornwall District Health Authority, 22 pp.
Duan N, Wang XL, Liu XD, Lin C, Hou J. (2010). Eff ect of anaerobic fermentation residues on a chromium-contaminated soil-vegetable system. Procedia Environmental Sciences 2: 1585-1597.
Ferner DJ. (2001). Toxicity, heavy metals. eMed J 2(5): 1.
Ferrara R, Mazzolai B, Lanzillotta E, Nucaro EA, Pirrone N. (2000). Temporal trends in gaseous mercury evasion from the Mediterranean seawaters. Sci Tot Environ 259(1-3): 183-190.
Fine JS. (2000). Iron poisoning. Curr Probl Pediatr 30(3): 71-90.
Flora SJS, Mittal M, Mehta A. (2008). Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian J Med Res 128: 501-523.
Gardner JL, Al-Hamdani SH. (1997). Interactive eff ects of aluminum and humic substances on Salvinia. J Aquat Plant Manage 35: 30-34.
Gerhardsson L, Dahlin L, Knebel R, Schutz A. (2002). Blood lead concentration after a shotgun accident. Environ Health Perspect 110(1): 115-117.
Ghani A. (2011). Eff ect of chromium toxicity on growth, chlorophyll and some mineral nutrients of Brassica juncea L. Egyptian Acad J Biol Sci 2(1): 9-15.
Gordon JJ, Quastel GH. (1948). Eff ect of organic arsenicals on enzyme system. Biochem J 42: 337-350.
Goyer RA. (1990). Lead toxicity: from overt to subclinical to subtle health effects. Environ Health Perspect 86: 177-181.
Grazuleviciene R, Nadisauskiene R, Buinauskiene J, Grazulevicius T. (2009). Effects of Elevated Levels of Manganese and Iron in Drinking Water on Birth Outcomes. Polish J of Environ Stud 18(5): 819-825.
Gupta N, Gaurav SS, Kumar A. (2013). Molecular Basis of Aluminium Toxicity in Plants: A Review. Am J of Plant Sci 4: 21-37.
Gurkan R, Ulusoy HI, Akcay M. (2012). Simultaneous determination of dissolved inorganic chromium species in wastewater/natural waters by surfactant sensitized catalytic kinetic spectrophotometry. Arabian J Chem [in press].
Haley BE. (2005). Mercury toxicity: genetic susceptibility and synergistic effects. Medical Veritas 2(2): 535-42.
Han JX, Shang Q, Du Y. (2009). Eff ect of environmental cadmium pollution on human health. Health 1(3): 159-166.Henson MC, Chedrese PJ. (2004). Endocrine disruption by cadmium, a common environmental toxicant with paradoxical eff ects on reproduction. Exp Biol Med (Maywood) 229(5): 383-392.
Hershko C, Link G, Ioav C. (1998). Pathophysiology of iron overload. Ann N Y Acad Sci 850: 191-201.
Hillman RS. (2001). Chapter 54. Hematopoietic agents: growth factors, minerals, and vitamins, in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 10th Edition (Hardman JG, Limbird LE, Gilman AG eds), pp. 1487-1518, New York: McGraw-Hill.
Hoque MA, Burgess WG, Shamsudduha M, Ahmed KM. (2011). Delineating low-arsenic groundwater environments in the Bengal Aquifer System, Bangladesh. Appl Geochem 26(4): 614-623.
Hughes JP, Polissar L, Van Belle G. (1988). Evaluation and synthesis of health eff ects studies of communities surrounding arsenic producing industries. Int J Epidemiol 17: 407-413.
Irfan M, Hayat S, Ahmad A, Alyemeni MN. (2013). Soil cadmium enrichment: Allocation and plant physiological manifestations. Saudi J Biol Sci 20(1): 1-10.
Jarup L. (2003). Hazards of heavy metal contamination. Br Med Bull 68(1): 167-182.
Jaishankar M, Mathew BB, Shah MS, Gowda KRS. (2014). Biosorption of Few Heavy Metal Ions Using Agricultural Wastes. Journal of Environment Pollution and Human Health 2(1): 1-6.
Khlifi R, Hamza-Chaff ai A. (2010). Head and neck cancer due to heavy metal exposure via tobacco smoking and professional exposure: A review. Toxicol Appl Pharmacol 248: 71-88.
Kochian LV, Pineros MA, Hoekenga OA. (2005). The physiology, genetics and molecular biology of plant aluminum resistance and toxicity. Plant and Soil 274: 175-195.
Koutras GA, Schneider AS, Hattori M, Valentine WN. (1965). Studies on chromated erythrocytes. Mechanisms of chromate inhibition of glutathione reductase. Br J Haematol 11(3): 360-369.
Krewski D, Yokel RA, Nieboer E, Borchelt D, Cohen J, Harry J, Rondeau V. (2007). Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. JJ Toxicol Environ Health B Crit Rev. 10(S1): 1-269.
Lambert M, Leven BA, Green RM. (2000). New methods of cleaning up heavy metal in soils and water. Environmental science and technology briefs for citizens. Kansas State University, Manhattan, KS.
Lamhamdi M, El Galiou O, Bakrim A, Novoa-Munoz JC, Arias-Estevez M, Aarab A, Lafont R. (2013). Eff ect of lead stress on mineral content and growth of wheat (Triticum aestivum and spinach (Spinacia oleracea) seedlings. Saudi J Biol Sci 20(1): 29-36.
Markowitz, M. (2000). Lead Poisoning. Pediatr Rev 21(10): 327-335.
Martin S, Griswold W. (2009). Human health eff ects of heavy metals. Environmental Science and Technology Briefs for Citizens (15): 1-6
Mathew BB, Tiwari A, Jatawa SK. (2011). Free radicals and antioxidants: A review. Journal of Pharmacy Research 4(12): 4340-4343.
Matschullat J. (2000). Arsenic in the geosphere - a review. Sci Total Environ 249(1-3): 297-312.
Matsumoto ST, Mantovani MS, Malaguttii MIA, Dias AL, Fonseca IC, Marin- Morales MA. (2006). Genotoxicity and mutagenicity of water contaminated with tannery effl uents, as evaluated by the micronucleus test and comet assay using the fi sh Oreochromis niloticus and chromosome aberrations in onion root-tips. Genet Mol Biol 29(1): 148-158.
Mazumder G. (2008). Chronic arsenic toxicity & human health. Indian J Med Res 128(4): 436-447.
McCord JM. (1998). Iron, free radicals, and oxidative injury. Semin Hematol 35: 5-12.
Mohanty M, Kumar Patra H. (2013). Eff ect of ionic and chelate assisted hexavalent chromium on mung bean seedlings (Vigna Radiata l. Wilczek. Var k-851) during seedling growth. JSPB 9(2): 232-241.
Morais S, Costa FG, Pereira ML. (2012). Heavy metals and human health, in Environmental health - emerging issues and practice (Oosthuizen J ed), pp. 227-246, InTech. Mosby CV, Glanze WD, Anderson KN. (1996). Mosby Medical Encyclopedia, The Signet: Revised Edition. St. Louis.
Mudgal V, Madaan N, Mudgal A, Singh RB, Mishra S. (2010). Eff ect of toxic metals on human health. Open Nutraceuticals J 3: 94-99.
Mutlu A, Lee BK, Park GH, Yu BG, Lee CH. (2012). Long-term concentrations of airborne cadmium in metropolitan cities in Korea and potential health risks. Atmos Environ 47: 164-173.
Nagajyoti PC, Lee KD, Sreekanth TVM. (2010). Heavy metals, occurrence and toxicity for plants: a review. Environ Chem Lett 8(3): 199-216.
Najeeb U, Ahmad W, Zia MH, Malik Z, Zhou W. (2014). Enhancing the lead phytostabilization in wetland plant Juncus eff usus L. through somaclonal manipulation and EDTA enrichment. Arab J Chem [in press].
Nath K, Shyam S, Singh D, Shanna YK. (2008). Eff ect of chromium and tannery effl uent toxicity on metabolism and growth in cowpea (Vigna sinensis L. Saviex Hassk) seedling. Res Environ Life Sci 1: 91-94.
Nelson RL. (1992). Dietary iron and colorectal cancer risk. Free Radic Biol Med 12(2): 161-168.
Nriagu JO. (1996). History of global metal pollution. Science 272: 223-4.
O’Brien T, Xu J, Patierno SR. (2001). Eff ects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest. In Molecular Mechanisms of Metal Toxicity and Carcinogenesis (pp. 173-182). Springer US.
Olaniran AO, Balgobind A, Pillay B. (2013). Bioavailability of heavy metals in soil: impact on microbial biodegradation of organic compounds and possible improvement strategies. Int J Mol Sci 14(5): 10197-10228.
Osweiler GD, Carson TL, Buck WB, Van Gelder GA. (1985). Clinical and diagnostic veterinary toxicology. Kendall/Hunt Publishing Company.
Papanikolaou NC, Hatzidaki EG, Belivanis S, Tzanakakis GN, Tsatsakis AM. (2005). Lead toxicity update. A brief review. Med Sci Monitor 11(10): RA329.
Patrick L. (2002). Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. Altern Med Rev 7(6): 456-471.
Patrick L. (2003). Toxic metals and antioxidants: Part II. The role of antioxidants in arsenic and cadmium toxicity. Altern Med Rev 8(2): 106-128.
Phippen B, Horvath C, Nordin R, Nagpal N. (2008). Ambient water quality guidelines for iron: overview. Ministry of Environment Province of British Columbia.
Regoli L. (2005). The Relative Contributions of Diff erent Environmental Sources to Human Exposure and the EU Cadmium Risk Assessment Meeting of UNECE Task Force on Heavy Metals. Presentation for the UNECE Long-Range-Trans-boundary Air Pollutants - Task Force on Heavy Metals 16-18 March, 2005 in Berlin.
Reilly C. (2007). Pollutants in Food - Metals and Metalloids, in Mineral Components in Foods, (Szefer P, Nriagu JO eds), pp. 363-388, Taylor & Francis Group, Boca Raton, FL.
Rodriguez MC, Barsanti L, Passarelli V, Evangelista V, Conforti V, Gualtieri P. (2007). Eff ects of chromium on photosynthetic and photoreceptive apparatus of the alga Chlamydomonas reinhardtii. Environ Res 105(2): 234-239.
Rosseland BO, Eldhuset TD, Staurnes M. (1990). Environmental eff ects of aluminium. Environ Geochem Health 12(1-2): 17-27.
Ryan TP, Aust SD. (1992). The role of iron in oxygen-mediated toxicities. Crit Rev Toxicol 22: 119-41.
Saha JC, Dikshit AK, Bandyopadhyay M, Saha KC. (1999). A review of arsenic poisoning and its eff ects on human health. Crit Rev Env Sci Technol 29(3): 281-313.
Satarug S, Garrett SH, Sens MA, Sens DA. (2011). Cadmium, environmental exposure, and health outcomes. Ciência & Saúde Coletiva 16(5): 2587-2602.
Schlatter C, Kissling U. (1973). Acute fatal bichromate poisoning. Beitrage zur Gerichtlichen Medizin 30: 382-388.
Schroeder HA, Nason AP, Tipton IH. (1970). Chromium defi ciency as a factor in atherosclerosis. J Chron Dis 23(2): 123-142.
Sharma P, Dubey RS. (2005). Lead toxicity in plants. Brazilian Journal of Plant Physiology 17(1): 35-52.
Singh N, Kumar D, Sahu A. (2007). Arsenic in the environment: eff ects on human health and possible prevention. J Environ Biol 28(2 Suppl): 359-365.
Smedley PL, Kinniburgh DG. (2002). A review of the source, behavior and distribution of arsenic in natural waters. Appl Geochem 17: 517-568.
Smith AH, Lingas EO, Rahman M. (2000). Contamination of drinking-water by arsenic in Bangladesh: a public health emergency. Bull World Health Organ 78(9): 1093-1103.
Stohs SJ, Bagchi D. (1995). Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 18(2): 321-336.
Taylor MP, Winder C, Lanphear BP. (2012). Eliminating childhood lead toxicity in Australia: a call to lower the intervention level. MJA 197(9): 493.
Teo J, Goh K, Ahuja A, Ng H, Poon W. (1997). Intracranial vascular calcifi cations, glioblastoma multiforme, and lead poisoning. AJNR 18: 576-579.
Thurmer K, Williams E, Reutt-Robey J. (2002). Autocatalytic oxidation of lead crystallite surfaces. Science 297(5589): 2033-2035.
Trasande L, Landrigan PJ, Schechter C. (2005). Public health and economic consequences of methyl mercury toxicity to the developing brain. Environ Health Perspect 113(5): 590-596.
U.S. EPA: (1993). Standard Methods for the Examination of Water and Wastewater, American Public Health Assoc. US.
Valko MMHCM, Morris H, Cronin MTD. (2005). Metals, toxicity and oxidative stress. Curr Med Chem 12(10): 1161-1208.
Vardar F, Unal M. (2007). Aluminum toxicity and resistance in higher plants. Adv Mol Biol 1: 1-12.
Vuori K-M. (1995). Direct and Indirect eff ects of iron on river eco systems. Annal Zoo Fennici 32: 317-329.
Wadhwa N, Mathew BB, Jatawa S, Tiwari A. (2012). Lipid peroxidation: mechanism, models and signifi cance. Int J Curr Sci 3: 29-38.
WHO. (1997). Aluminium. Geneva, World Health Organization, International Programme on Chemical Safety (Environmental Health Criteria 194).
WHO. (2004). Guidelines for drinking-water quality. Sixty-fi rst meeting, Rome, 10-19 June 2003. Joint FAO/WHO Expert Committee on Food Additives, Avaible from http://ftp.fao.org/es/esn/jecfa/jecfa61sc.pdf).
Wolińska A, Stępniewska Z, Włosek R. (2013). The infl uence of old leather tannery district on chromium contamination of soils, water and plants. Nat Sci 5(2A): 253-258.
Yongsheng W, Qihui L, Qian T. (2011). Eff ect of Pb on growth, accumulation and quality component of tea plant. Procedia Engineering 18: 214-219.
Zayed AM, Terry N. (2003). Chromium in the environment: factors aff ecting biological remediation. Plant Soil 249(1): 139-156.
Zhitkovich A. (2005). Importance of chromium-DNA adducts in mutagenicity and toxicity of chromium (VI). Chem Res Toxicol 18(1): 3-11.