Research Progress on Chlamydia trachomatis Infection and Related Cytokines

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Abstract

Chlamydia trachomatis (Ct) infection can induce host cells to produce numerous cytokines. Cytokines play important roles in inflammatory response. Although inflammation can protect the body, persistent inflammation can lead to pathological changes and tissue damages. Further research should determine whether cytokine production directly affects development and outcomes of inflammation. This study summarizes Ct infection and related cytokines.

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  • 1 Cheng W Shivshankar P Li Z et al. Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection. Infect Immun 2008 76:515-522.

  • 2 Hvid M Baczynska A Deleuran B et al. Interleukin-1is the initiator of Fallopian tube destruction during Chlamydia trachomatis infection. Cell Microbiol 2007 9:2795-2803.

  • 3 Lu H Shen C Brunham RC. Chlamydia trachomatis infection of epithelial cells induces the activation of caspase-1 and release of mature IL-18. J Immunol 2000 165:1463-1469.

  • 4 Cheng W Shivshankar P Zhong Y et al. Intracellular interleukin-1alpha mediates interleukin-8 production induced by Chlamydia trachomatis infection via a mechanism independent of type I interleukin-1 receptor. Infect Immun 2008 76: 942-951.

  • 5 Li H Liang Z. Determination of tumor necrosis factor α and interleukin 6 in tubal fluid of patients with tubal infertility caused by the infection of Chlamydia trachomatis. Chin J Obstet Gynecol 2000 35:26-27.

  • 6 Buchholz KR Stephens RS. The extracellular signal-regulated kinase/mitogen-activated protein kinase pathway induces the inflammatory factor interleukin-8 following Chlamydia trachomatis infection. Infect Immun 2007 75:5924-5929.

  • 7 Schrader S Klos A Hess S et al. Expression of inflammatory host genes in Chlamydia trachomatis-infected human monocytes. Arthritis Res Ther 2007 9:R54.

  • 8 Gao X Gigoux M Yang J et al. Anti-chlamydial Th17 responses are controlled by the inducible costimulator partially through phosphoinositide 3-kinase signaling. PLoS One 2012 7: e39214.

  • 9 Zhang Y Wang H Ren J et al. IL-17 Asynergizes with IFN-gamma to upregulate iNOS and NO production and inhibit chlamydial growth. PLoS One 2012 7: e39214.

  • 10 Yilma AN Singh SR Fairley SJ et al. The anti-inflammatory cytokine interleukin-10 inhibits inflammatory mediators in human epithelial cells and mouse macrophages exposed to live and UV-inactivated Chlamydia trachomatis. Mediators Inflamm 2012 DI 2012:520174.

  • 11 Wang C Tang J Geisler WM et al. Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescents. J Infect Dis 2005 191:1084-1092.

  • 12 Skwor TA Atik B Kandel RP et al. Role of secreted conjunctival mucosal cytokine and chemokine proteins in different stages of trachomatous disease. PLoS Negl 2008 2: e264.

  • 13 Buckner LR Lewis ME Greene SJ et al. Chlamydia trachomatis infection results in a modest pro-inflammatory cytokine response and a decrease in T cell chemokine secretion in human polarized endocervical epithelial cells. Cytokine 2013 63:151-165.

  • 14 Vicetti Miguel RD Harvey SA LaFramboise WA et al. Human female genital tract infection by the obligate intracellular bacterium Chlamydia trachomatis elicits robust type 2 Immunity. PLoS One 2013 8: e58565.

  • 15 Clancy R Ren Z Pang G et al. Chronic Chlamydia pneumoniae infection may promote coronary artery disease in humans through enhancing secretion of interleukin-4. Clin Exp Immunol 2006 146:197-202.

  • 16 Prantner D Sikes JD Hennings L et al. Interferon regulatory transcription factor 3protects mice from uterine horn pathology during Chlamydia muridarum genital infection. Infect Immun 2011 79:3922-3933.

  • 17 Barker JR Koestler BJ Carpenter VK et al. Sting-dependent recognition of cyclic diAMP mediates type I interferon responses during Chlamydia trachomatis infection. MBio 2013 4: e00018-00013.

  • 18 Burian K Endresz V Deak J et al. Transcriptome analysis indicates an enhanced activation of adaptive and innate immunity by chlamydia-infected murine epithelial cells treated with interferon gamma. J Infect Dis 2010 202:1405-1414.

  • 19 Ishihara T Aga M Hino K et al. Inhibition of Chlamydia trachomatis growth by human interferon-α: mechanisms and synergistic effect with interferon-γ and tumor necrosis factor-α. Biomed Res 2005 26:179-185.

  • 20 Zhang C Tian Z. Negative immunomodulatory effect of interferonγ. Current Immunology 2007 2:89-92.

  • 21 Zha J Shu H. Molecular mechanism of signal transduction of tumor necrosis factor. SCIENTIA SINICA(C series: Life Sciences) 2002 01:1-12.

  • 22 Kim JH Jiang S Elwell CA et al. Chlamydia trachomatis co-opts the FGF2signaling pathway to enhance infection. PLoS Pathog 2011 7: e1002285.

  • 23 Burton MJ Ramadhani A Weiss HA et al. Active trachoma is associated with increased conjunctival expression of IL17A and profibrotic cytokines. Infect Immun 2011 79:4977-4983.

  • 24 Belay T Eko FO Ananaba GA et al. Chemokine and chemokine receptor dynamics during genital chlamydial infection. Infect Immun 2002 70:844-850.

  • 25 Mathai SK Gulati M Peng X et al. Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype. Lab Invest 2010 90:812-823.

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