Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

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Medicinal plants have been used for thousands of years in folk medicines and still are used for their health benefits. In our days medicinal plants are exploited for the isolation of plant-derived drugs as they are very effective and have relatively less or no side effects. However, the natural resources of medicinal plants are gradually exhausted and access to plant bioactive compounds is challenged by the low levels at which these products accumulate in native medicinal plants. For instance, to meet the market demands of 3 Kg per year of vinca alkaloids, powerful plant-derived anticancer drugs, 1.5×106 Kg dry leaves are required. In this regard, this review aims to highlight the fact that endophytic fungi residing in medicinal plants are capable to biosynthesize pharmacologically active secondary metabolites similar or identical to those produced by their host medicinal plant. Furthermore, the evolutionary origin of the genes involved in these metabolic pathways as well as the approaches designed to enhance the production of these metabolites by the isolated endophytic fungi are also discussed.

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  • Atanasov A.G. Waltenberger B. Pferschy-Wenzig E.M. Linder T. Wawrosch C. Uhrin P. Temml V. Wang L. Schwaiger S Heiss E.H. Rollinger J.M. Schuster D. Breuss J.M. Bochkov V. Mihovilovic M.D. Kopp B. Bauer R Dirsch V.M. and Rollinger J. M. 2015. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnology advances 33: 1582-1614.

  • Bhalkar B.N. Patil S. M. and Govindwar S.P. 2016. Camptothecine production by mixed fermentation of two endophytic fungi from Nothapodytes nimmoniana. Fungal Biology 120: 873-883.

  • Bomke C. and Tudzynski B. 2009. Diversity regulation and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteria. Phytochemistry 70: 1876-1893.

  • Butelman E.R. and Kreek M.J. 2015. Salvinorin A a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Frontiers in Pharmacology 6: 285.

  • Carrier D.J. van Beek T.A. van der Heijden R. and Veroorte R. 1998. Distribution of ginkgolides and terpenoids biosynthetic activity in Ginkgo biloba. Phytochemistry 48: 89-92.

  • Chen S.L. Yu H. Luo H.M. Wu Q. Li C.F. and Steinmetz A. 2016. Conservation and sustainable use of medicinal plants: problems progress and prospects. Chinese Medicine 11: 37.

  • Chiang H.M. Chen H.C. Wu C.S. Wu P.Y. and Wen K.C. 2015. Rhodiola plants: chemistry and biological activity. Journal of Food and Drug Analysis 23: 359-369.

  • Chithra S. Jasim B. Anisha C. Mathew J. and Radhakrishnan E.K. 2014. LC-MS/MS based nidentifi cation of piperine production by endophytic Mycosphaerella sp. PF13 from Piper nigrum. Applied Biochemistry Biotechnology 173: 30-35.

  • Chun-Yan S.U. Qian-Liang M.I.N.G. Rahman K. Ting H.A.N. and Lu-Ping Q.I.N. 2015. Salvia miltiorrhiza: Traditional medicinal uses chemistry and pharmacology. Chinese Journal of Natural Medicines 13: 163-182.

  • Cui J. Guo T. Chao J. Wang M. and Wang J. 2016. Potential of the endophytic fungus Phialocephala fortinii Rac56 found in Rhodiola plants to produce salidroside and p-tyrosol. Molecules 21: 502.

  • Cui J.L. Guo T.T. Ren Z.X. Zhang N.S. and Wang M.L. 2015. Diversity and antioxidant activity of culturable endophytic fungi from alpine plants of Rhodiola crenulata R. angusta and R. sachalinensis. PloS one 10: e0118204.

  • Cui Y. Yi D. Bai X. Sun B. Zhao Y. and Zhang Y. 2012. Ginkgolide B produced endophytic fungus (Fusarium oxysporum) isolated from Ginkgo biloba. Fitoterapia 83: 913-920.

  • Cutignano A. Villani G. and Fontana A. 2012. One metabolite two pathways: convergence of polypropionate biosynthesis in fungi and marine molluscs. Organic letters 14: 992-995.

  • Devari S. Jaglan S. Kumar M. Deshidi R. Guru S. Bhushan S. and Taneja S.C. 2014. Capsaicin production by Alternaria alternata an endophytic fungus from Capsicum annum; LC-ESI-MS/MS analysis. Phytochemistry 98: 183-189.

  • Dziggel C. Schafer H. and Wink M. 2017. Tools of pathway reconstruction and production of economically relevant plant secondary metabolites in recombinant microorganisms. Biotechnology Journal 2:1666145.

  • El-Elimat T. Raja H.A. Graf T.N. Faeth S.H. Cech N.B. and Oberlies N.H. 2014. Flavonolignans from Aspergillus iizukae a fungal endophyte of milk thistle (Silybum marianum). Journal of Natural Products 77: 193-199.

  • El-Hawary S.S. Mohammed R. AbouZid S.F. Bakeer W. Ebel R. Sayed A.M. and Rateb M.E. 2016. Solamargine production by a fungal endophyte of Solanum nigrum. Journal of Applied Microbiology 1201: 143-50.

  • El-Sayed A.S. Abdel-Ghany S.E. and Ali G.S. 2017. Genome editing approaches: manipulating of lovastatin and taxol synthesis of fi lamentous fungi by CRISPR/Cas9 system. Applied Microbiology and Biotechnology 101: 3953-3976.

  • Feher J. and Lengyel G. 2012. Silymarin in the prevention and treatment of liver diseases and primary liver cancer. Current Pharmaceutical Biotechnology 13: 210-217.

  • Gokhale M.S. GuptaD. Gupta U. Fara R. and Sandhu S.S. 2017. Patents on Endophytic Fungi. Recent Patents on Biotechology doi:

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  • Gorgani L. Mohammadi M. Najafpour G.D. and Nikzad M. 2017. Piperine-The bioactive compound of black pepper: from isolation to medicinal formulations. Comprehensive Reviews in Food Science and Food Safety 16: 124-140.

  • Gu Y.H. and Wu Q.Q. 2005. HPLC method for the determination of huperzine A in Huperzia serrata. China Pharmacology Bulletin 21: 1017-1018

  • Hamayun M. Hussain A. Khan S.A. Kim H.Y. Khan A.L. Waqas M. Irshad M. Iqbal A. Rehman G. Jan S. and Lee I.J. 2017. Gibberellins producing endophytic fungus Porostereum spadiceum AGH786 rescues growth of salt aff ected soybean. Frontiers in Microbiology 8.

  • Hu X. Li W. Yuan M. Li C. Liu S. Jiang C. Wu Y. Cai K. and Liu Y. 2016. Homoharringtonine production by endophytic fungus isolated from Cephalotaxus hainanensis Li. World Journal of Microbiology and Biotechnology 32: 1-9.

  • Jain R. Sharma A. Gupta S. Sarethy I.P. and Gabrani R. 2011. Solanum nigrum: current perspectives on therapeutic properties. Alternative Medicine Review 16: 78-85.

  • Jensen N.B. Zagrobelny M. Hjerno K. Olsen C.E. Houghton-Larsen J. Borch J. Moller B.L. and Bak S. 2011. Convergent evolution in biosynthesis of cyanogenic defence compounds in plants and insects. Nature Communications 2: 273.

  • Kantas D. Papatsiros V.G. Tassis P.D. Athanasiou L.V. and Tzika E.D. 2015. The eff ect of a natural feed additive (Macleaya cordata) containing sanguinarine on the performance and health status of weaning pigs. Animal Science Journal 86: 92-98.

  • Kaufman T.S. and Ruveda E.A. 2005. The quest for quinine: those who won the battles and those who won the war. Angewandte Chemie 44: 854-885.

  • Kaul S. Ahmed M. Zargar K. Sharma P. and Dhar M.K. 2013. Prospecting endophytic fungal assemblage of Digitalis lanata Ehrh.(foxglove) as a novel source of digoxin: a cardiac glycoside.3 Biotech 3: 335-340.

  • Kavitha C. Rajamani K. and Vadivel E. 2010. Coleus forskohlii -A comprehensive review on morphology phytochemistry and pharmacological aspects. Journal of Medicinal Plants Research 4: 278-285.

  • Kiewert C. Kumar V. Hildmann O. Hartmann J. Hillert M. and Klein J. 2008. Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide. Brain Research 27: 143-150.

  • Kharwar R.N. Verma V.C. Strobel G. and Ezra D. 2008. The endophytic fungal complex of Catharanthus roseus (L.) G. Don. Current Science 95: 228-233.

  • Krings M. Taylor T.N. Hass H. Kerp H. Dotzler N. and Hermsen E.J. 2007. Fungal endophytes in a 400-million-yr-old land plant: infection pathways spatial distribution and host responses. New Phytology 174: 648-657.

  • Kumar A. Patil D. Rajamohanan P.R. and Ahmad A. 2013. Isolation purifi cation and characterization of vinblastine and vincristine from endophytic fungus Fusarium oxysporum isolated from Catharanthus roseus. PloS one 8: e71805.

  • Kumara P.M. Soujanya K.N. Ravikanth G. Vasudeva R. Ganeshaiah K.N. and Shaanker R.U. 2014. Rohitukine a chromone alkaloid and a precursor of fl avopiridol is produced by endophytic fungi isolated from Dysoxylum binectariferum Hook.f and Amoora rohituka (Roxb). Phytomedicine 21:541-546

  • Kuriakose G.C. Palem P.P. and Jayabaskaran C. 2016. Fungal vincristine from Eutypella spp- CrP14 isolated from Catharanthus roseus induces apoptosis in human squamous carcinoma cell line-A431. BMC Complementary and Alternative Medicine 16: 302.

  • Kusari S. Zuelke S. and Spiteller M. 2011. Eff ect of artifi cial reconstitution of the interaction between the plant Camptotheca acuminate and the fungal endophyte Fusarium solani on camptothecin biosynthesis. Journal of Natural Products 74: 764-775.

  • Kusari S. Hertweck C. and Spiteller M. 2012. Chemical ecology of endophytic fungi: origins of secondary metabolites. Chemistry and Biology 19: 792-798.

  • Kusari S. Singh S. and Jayabaskaran C. 2014. Rethinking production of Taxol (paclitaxel) using endophyte biotechnology. Trends in Biotechnology 32: 304-311.

  • Li X. Zhai X. Shu Z. Dong R. Ming Q. Qin L. and Zheng C. 2016. Phoma glomerata D14: An Endophytic Fungus from Salvia miltiorrhiza. Current Microbiology 73: 31-37.

  • Liang L. Luo M. Fu Y. Zu Y. Wang W. Gu C. Zhao C. Li C. and Eff erth T. 2013. Cajaninstilbene acid (CSA) exerts cytoprotective eff ects against oxidative stress through the Nrf2-dependent antioxidant pathway. Toxicology Letters 219: 254-261.

  • Lu X. Chen G. Hua H. Dai H. Mei W. Xu Y. and Pei Y. 2012. Aromatic compounds from endophytic fungus Colletotrichum sp. L10 of Cephalotaxus hainanensis Li. Fitoterapia 83 737-741.

  • Luo M. Liu X. Zu Y. Fu Y. Zhang S. Yao L. and Efferth T. 2010. Cajanol a novel anticancer agent from Pigeonpea [Cajanus cajan (L.) Millsp.] roots induces apoptosis in human breast can cer cells through a ROS-mediated mitochondrial pathway. Chemico-biological Interactions 188: 151-160.

  • Maehara S. Simanjuntak P. Maetani Y. Kitamura C. Ohashi K. and Shibuya H. 2013. Ability of endophytic fi lamentous fungi associated with Cinchona ledgeriana to produce Cinchona alkaloids. Journal of Natural Medicines 67: 421-423.

  • Maehara S. Simanjuntak P. Kitamura C. Ohashi K. and Shibuya H. 2011. Cinchona alkaloids are also produced by an endophytic fi lamentous fungus living in Cinchona plant. Chemical and Pharmaceutical Bulletin 59: 1073-1074.

  • Magotra A. Kumar M. Kushwaha M. Awasthi P. Raina C. Gupta A. P. ShahB.A Gandhi SG and Chaubey A. 2017. Epigenetic modifi er induced enhancement of fumiquinazoline C production in Aspergillus fumigatus (GA-L7): an endophytic fungus from Grewia asiatica L. AMB Express 7: 43.

  • Malik S. Cusido R.M. Mirjalili M.H. Moyano E. Palazon J. and Bonfi ll M. 2011. Production of the anticancer drug taxol in Taxus baccata suspension cultures: A review. Process Biochemistry 46: 23-34.

  • Manda V.K. Avula B. Dale O.R. Chittiboyina A.G. Khan I.A. Walker L.A. and Khan S.I. 2015. Studies on pharmacokinetic drug interaction potential of vinpocetine. Medicines 2: 93-105.

  • Ming Q. Han T. Li W. Zhang Q. Zhang H. Zheng C. and Qin L. 2012. Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16 an endophytic fungus in Salvia miltiorrhiza. Phytomedicine 19: 330-333.

  • Mir R.A. Kaushik S.P. Chowdery R.A and Anuradha M. 2015. Elicitation of Forskolin in Cultures of Rhizactonia bataticola - A Phytochemical Synthesizing Endophytic Fungi. International Journal of Pharmacy and Pharmaceutical Sciences 7: 10.

  • Mousa W.K. Shearer C. Limay-Rios V. Ettinger C.L. Eisen J.A. and Raizada M.N. 2016. Roothair endophyte stacking in fi nger millet creates a physicochemical barrier to trap the fungal pathogen Fusarium graminearum. Nature Microbiology 1: 16167.

  • Na R. Jiajia L. Dongliang Y. Yingzi P. Juan H. Xiong L. Nana Z. Jing Z. and Yitian L. 2016. Indentifi cation of vincamine indole alkaloids producing endophytic fungi isolated from Nerium indicum Apocynaceae. Microbiological Research 192: 114-121.

  • Pan F. Hou K. Gao F. Hu B. Chen Q. and Wu W. 2014. Peimisine and peiminine production by endophytic fungus Fusarium sp. isolated from Fritillaria unibracteata var. wabensis. Phytomedicine 21: 1104-1109.

  • Pan F. Su X. Hu B. Yang N. Chen Q. and Wu W. 2015. Fusarium redolens 6WBY3 an endophytic fungus isolated from Fritillaria unibracteata var. wabuensis produces peimisine and imperialine- 3β-d-glucoside. Fitoterapia 103: 213-221.

  • Pan F. Su T.J. Cai S.M. and Wu W. 2017. Fungal endophyte-derived Fritillaria unibracteata var. wabuensis: diversity antioxidant capacities in vitro and relations to phenolic fl avonoid or saponin compounds. Scientifi c Reports 7.

  • Pan S.Y. Zhou S.F. Gao S.H. Yu Z.L. Zhang S.F. Tang M.K. Sun J.N. Ma D.L. Han Y.F. Fong W.F. and Ko K.M. 2013. New Perspectives on How to Discover Drugs from Herbal Medicines: CAM’s Outstanding Contribution to Modern Therapeutics. Evidence-based complementary and alternative medicine: eCAM 2: 627375.

  • Panaccione D.G. Beaulieu W.T. and Cook D. 2014. Bioactive alkaloids in vertically transmitted fungal endophytes. Functional Ecology 28: 299-314.

  • Palem P.P. Kuriakose G.C. and Jayabaskaran C. 2015. An endophytic fungus Talaromyces radicus isolated from Catharanthus roseus produces vincristine and vinblastine which induce apoptotic cell death. PloS one 10: e0144476

  • Pateraki I. Andersen-Ranberg J. Jensen N.B. Wubshet S.G. Heskes A.M. Forman V. Hallstrom B Hamberger B Motawia M.S. Olsen C.E. Staerk D. Hansen J. Moller B.L. and Staerk D. 2017. Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii. Elife 6: e23001.

  • Pateraki I. Andersen-Ranberg J. Hamberger B. Heskes A.M. Martens H.J. Zerbe P. Bach S.S. Moller B.L. Bohlmann J. and Hamberger B. 2014. Manoyl oxide (13R) the biosynthetic precursor of forskolin is synthesized in specialized root cork cells in Coleus forskohlii. Plant Physiology 164: 1222-1236.

  • Pérez-Alonso N. Wilken D. Gerth A. Jahn A. Nitzsche H.M. Kerns G. and Jimenez E. 2009. Cardiotonic glycosides from biomass of Digitalis purpurea L. cultured in temporary immersion systems. Plant Cell Tissue and Organ Culture 99: 151-156.

  • Petrini O. and Fisher P. 1990. Occurrence of fungal endophytes in twigs of Salix fragilis and Quercus robur. Mycological Research 94: 1077-80.

  • Piao X.L. Jang M.H. Cui J. and Piao X.S. 2008. Lignans from the fruits of Forsythia suspensa. Bioorganic Medical Chemistry Letters 18: 1980-1984.

  • Pu X. Qu X. Chen F. Bao J. Zhang G. and Luo Y. 2013. Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation identifi cation and fermentation conditions optimization for camptothecin production. Applied Microbiology and Biotechnology 97: 9365-9375.

  • Qian Y.X. Kang J.C. Luo Y.K. Zhao J.J. He J. and Geng K. 2016. A Bilobalide-Producing Endophytic Fungus Pestalotiopsis uvicola. Current Mi crobiology 73: 280-286.

  • Qu H. Zhang Y. Wang Y. Li B. and Sun W. 2008. Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from Forsythia suspensa. Journal Pharmacy Pharmacology 60: 261-266.

  • Rai A. Saito K. and Yamazaki M. 2017. Integrated omics analysis of specialized metabolism in medicinal plants. The Plant Journal 90: 764-787.

  • Ramesha B.T. Suma H.K. Senthilkumar U. Priti V. Ravikanth G. Vasudeva R. Kumar T.R.S Ganeshaiah K.N. and Shaanker R.U. 2013. New plant sources of the anti-cancer alkaloid camptothecine from the Icacinaceae taxa India. Phytomedicine 20: 521-527.

  • Ramirez-Estrada K. Vidal-Limon H. Hidalgo D. Moyano E. Golenioswki M. Cusido R.M. and Palazon J. 2016. Elicitation an eff ective strategy for the biotechnological production of bioactive high-added value compounds in plant cell factories. Molecules 21: 182.

  • Richards T.A. Soanes D.M. Foster P.G. Leonard G. Thornton C.R. and Talbot N.J. 2009. Phylogenomic analysis demonstrates a pattern of rare and ancient horizontal gene transfer between plants and fungi. The Plant Cell 21: 1897-1911.

  • Rodriguez R.J. White Jr.J.F. Arnold A.E. and Redman R.S. 2009. Fungal endophytes: diversity and functional roles. New Phytolology 182: 314-330.

  • Sachin N. Manjunatha B.L Kumara P.M Ravikanth G. Shweta S. Suryanarayanan T.S. Ganeshaiah K.N. and Shaanker R.U. 2013. Do endophytic fungi possess pathway genes for plant secondary metabolites? Current Science 104: 178-182

  • Saurabh C.V. and Kishor N.G. 2013. Vinpocetine: hype hope and hurdles towards neuroprotection. Asian Journal of Pharmacological Research Developments 1: 17-23.

  • Seetharaman P. Gnanasekar S. Chandrasekaran R. Chandrakasan G. Kadarkarai M. and Sivaperumal S. 2017. Isolation and characterization of anticancer fl avone chrysin (5 7-dihydroxy fl avone)-producing endophytic fungi from Passifl ora incarnata L. leaves. Annals of Microbiology 67: 321-331.

  • Shweta S. Bindu J. H. Raghu J. Suma H.K. Manjunatha B.L. Kumara P.M. Ravikanth G. Nataraja K.N Ganeshaiah K.N. and Shaanker R.U. 2013. Isolation of endophytic bacteria producing the anti-cancer alkaloid camptothecine from Miquelia dentata Bedd. (Icacinaceae). Phytomedicine 20: 913-917.

  • Shweta S. Gurumurthy B.R. Ravikanth G. Ramanan U.S. and Shivanna M.B. 2013. Endophytic fungi from Miquelia dentata Bedd. produce the anti-cancer alkaloid camptothecine. Phytomedicine 20: 337-342.

  • Slot J.C. and Rokas A. 2011. Horizontal transfer of a large and highly toxic secondary metabolic gene cluster between fungi. Current Biology 21: 134-139.

  • Soliman S.S. Greenwood J.S. Bombarely A. Mueller L.A. Tsao R. Mosser D.D. and Raizada M.N. 2015. An endophyte constructs fungicide-containing extracellular barriers for its host plant. Current Biology 25: 2570-2576.

  • Soliman S.S. Trobacher C.P. Tsao R. Greenwood J.S. and Raizada M.N. 2013. A fungal endophyte induces transcription of genes encoding a redundant fungicide pathway in its host plant. BMC Plant Biology 13: 93.

  • Soliman S.S. and Raizada M.N. 2013. Interactions between co-habitating fungi elicit synthesis of Taxol from an endophytic fungus in host Taxus plants. Frontiers in Microbiology 4: 3.

  • Srinivasan K. 2016. Biological activities of red pepper (Capsicum annuum) and its pungent principle capsaicin: a review. Critical Reviews in Food Science and Nutrition 56: 1488-1500.

  • Staniek A. Bouwmeester H. Fraser P.D. Kayser O. Martens S. Tissier A. and Warzecha H. 2014. Natural products-learning chemistry from plants. Biotechnology journal 9: 326-336.

  • Stierle A.A. and Stierle D.B. 2015. Bioactive secondary metabolites produced by the fungal endophytes of conifers. Natural Product Communications 10: 1671.

  • Stierle A. Strobel G. and Stierle D. 1993. Taxol and taxane production by Taxomyces andreanae an endophytic fungus of Pacifi c yew. Science 260: 214-214.

  • Su J. Liu H. Guo K. Chen L. Yang M. and Chen Q. 2017. Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review. Molecules 22: 176.

  • Tu Y. 2011. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nature medicine 17: 1217-1220.

  • Tudzynski B. Studt L. and Rojas C. 2016. Gibberellins in fungi bacteria and lower plants: biosynthesis function and evolution. Annual Plant Reviews 49: 121-152.

  • Usai S. Grazzi L. and Bussone G. 2011. Gingkolide B as migraine preventive treatment in young age: results at 1-year follow-up. Neurological Science 1:197-199

  • Vasanthakumari M.M. Jadhav S.S. Sachin N. Vinod G. Shweta S. Manjunatha B.L. Ravikanth G. Nataraja K.N. Kumara P.M. and Shaanker R.U. 2015. Restoration of camptothecine production in attenuated endophytic fungus on reinoculation into host plant and treatment with DNA methyltransferase inhibitor. World Journal of Microbiology and Biotechnology 31: 1629-1639.

  • Verma V.C. Lobkovsky E. Gange A.C. Singh S.K. and Prakash S. 2011. Piperine production by en dophytic fungus Periconia sp. isolated from Piper longum L. Journal of Antibiotics 64: 427-431.

  • Wakai S. Arazoe T. Ogino C. and Kondo A. 2017. Future insights in fungal metabolic engineering. Bioresource Technology. doi.org/10.1016/j. biortech.2017.04.095.

  • Wang D. Zhu J. Wang S. Wang X. Ou Y. Wei D. and Xueping L. 2011. Antitussive expectorant and anti-infl ammatory alkaloids from Bulbus Fritillariae cirrhosae. Fitoterapia 82: 1290-1294.

  • Wang Y. Lai Z. Li X.X. Yan R. M. Zhang Z.B. Yang H.L. and Zhu D. 2016. Isolation diversity and acetylcholinesterase inhibitory activity of the culturable endophytic fungi harboured in Huperzia serrata from Jinggang Mountain China. World Journal of Microbiology and Biotechnology 32: 20.

  • Wang X.J. Min C.L. Ge M. and Zuo R.H. 2014. An endophytic sanguinarine-producing fungus from Macleaya cordata Fusarium proliferatum BLH51. Current Microbiology 68: 336-341.

  • Wei G. Wang J. and Du Y. 2011. Total synthesis of solamargine. Bioorganic Medical Chemistry Letters 21: 2930-2933.

  • Wu Y.B. Ni Z.Y. Shi Q.W. Dong M. Kiyota H. Gu Y.C. and Cong B. 2012. Constituents from Salvia species and their biological activities. Chemical Reviews 112: 5967-6026.

  • Xiong Z.Q. Yang Y.Y. Zhao N. and Wang Y. 2013. Diversity of endophytic fungi and screening of fungal paclitaxel producer from Anglojap yew Taxus x media. BMC Microbiology 13: 71

  • Xue H. Lu C. Liang L. and Shen Y. 2012. Secondary Metabolites of Aspergillus sp. CM9a an Endophytic Fungus of Cephalotaxus mannii. Records of Natural Products 6: 28.

  • Yang H. PengS. Zhang Z. Yan R. Wang Y. Zhan J. Zhu J. and ZhuD. 2014. Whole-genome shotgun assembly and analysis of the genome of Shiraia sp. strain Slf14 a novel endophytic fungus producing huperzine A and hypocrellin A. Genome Announcements 2: e00011-14.

  • Yang H. Peng S. Zhang Z. Yan R. Wang Y. Zhan J. and Zhu D. 2016. Molecular cloning expression and functional analysis of the copper amine oxidase gene in the endophytic fungus Shiraia sp. Slf14 from Huperzia serrata. Protein Expression and Purifi cation 128: 8-13.

  • Yang Y. Zhao H. Barrero R.A. Zhang B. Sun G. Wilson I.W. and Guo G. 2014. Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431. BMC Genomics 15: 69.

  • Yin H. and Sun Y.H. 2011. Vincamine-producing endophytic fungus isolated from Vinca minor. Phytomedicine 18: 802-805.

  • You X. Feng S. Luo S. Cong D. Yu Z. Yang Z. and Zhang J. 2013. Studies on a rhein-producing endophytic fungus isolated from Rheum palmatum L. Fitoterapia 85: 161-168.

  • Yu X. Gao X. Zhu Z. Cao Y. Zhang Q. Tu P. and Chai X. 2014. Alkaloids from the Tribe Bocconieae (Papaveraceae): A Chemical and Biological Review. Molecules 19: 13042-13060.

  • Zhang F. Chen B. Xiao S. and Yao S.Z. 2005. Optimization and comparison of diff erent extraction techniques for sanguinarine and chelerythrine in fruits of Macleaya cordata (Willd) R. Br. Separation and Purifi cation Technology. 42: 283-290.

  • Zhao X.M. Wang Z.Q. Shu S.H. Wang W.J. Xu H. J. Ahn Y.J. and Hu X. 2013. Ethanol and methanol can improve huperzine A production from endophytic Colletotrichum gloeosporioides ES026. PLoS One 8 e61777.

  • Zhang G. Wang W. Zhang X. Xia Q. Zhao X. Ahn Y. and Shu S. 2015. De novo RNA sequencing and transcriptome analysis of Colletotrichum gloeosporioides ES026 reveal genes related to biosynthesis of huperzine A. PloS one 10: e0120809.

  • Zhang Q. Wei X. and Wang J. 2012. Phillyrin produced by Colletotrichum gloeosporioides an endophytic fungus isolated from Forsythia suspensa. Fitoterapia 83: 1500-1505.

  • Zhao J. Fu Y. Luo M. Zu Y. Wang W. Zhao C. Zhao C. and Gu C. 2012. Endophytic fungi from pigeon pea [Cajanus cajan (L.) Millsp.] produce antioxidant cajaninstilbene acid. Journal of Agricultural and Food hemistry 60: 4314-4319.

  • Zhao J. Li C. Wang W. Zhao C. Luo M. Mu F. Fu Y. Su Y. and Yao M. 2013. Hypocrea lixii novel endophytic fungi producing anticancer agent cajanol isolated from pigeon pea (Cajanus cajan [L.] Millsp.). Journal of Applied Microbiology 115: 102-113.

  • Zhao J. Shan T. Mou Y. and Zhou L. 2011. Plantderived bioactive compounds produced by endophytic ungi. Mini reviews in medicinal chemistry 11: 159-168.

  • Zheng C.J. Sun P.X. Jin G.L. and Qin L.P. 2011. Sesquiterpenoids from Trichoderma atroviride an endophytic fungus in Cephalotaxus fortunei. Fitoterapia 82: 1035-1038.

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