The Effects of Clinoptilolite Administration on the Appetite, the Consistency of Faeces and the Histology of the Small Intestine in Growing Pigs

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Abstract

Clinoptilolite (Cp) is the most common and suitable natural zeolite type for many commercial and industrial applications. Recent studies have also shown a high potential of clinoptilolite in various medical applications. The aim of our study was to evaluate the effect of long-term peroral administration of clinoptilolite on appetites, the consistency of faeces, and the histopathology of the intestines of growing pigs. Fourteen Landrace × Large White crossbred pigs of both genders, a few days after weaning (12.95 kg b. w.), were divided into two equal groups. The control group was fed with a basal feed mixture, and the experimental group with a feed mixture supplemented with 2 % of natural zeolite (the commercial preparation “ZeoFeed”). The appetite, clinical state and consistency of the faeces were assessed every day. The blood samples were collected on days 0, 21, and 42 of the experiment. Histological examinations of the intestines from the control and experimental animals were carried out at the end of the experiments. The supplementation of 2 % Cp did not affect neither the appetite nor the clinical state of the pigs. The faecal consistency score in the experimental animals was 18.82 % lower than that of the control piglets. The histopathological evaluations showed protective evidence of the Cp on the intestinal tract wall in the duodenum and jejunum.

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  • 1. Alexopoulos C. Papaioannou D. S. Fortomaris P. Kyriakis C. S. Tserveni-Goussi A. Yannakopoulos A. Kyriakis S. C. 2007: Experimental study on the effect of in-feed administration of a clinoptilolite-rich tuff on certain biochemical and haematological parameters of growing and fattening pigs. Livest. Sci. 111 230—241. DOI: 10.1016/j.livsci.2007.01.152.

  • 2. Ball R. O. Aherne F. X. 1982: Effect of diet complexity and feed restriction on the incidence and severity of diarrhoea in early-weaned pigs. Can. J. Anim. Sci. 62 907—913.

  • 3. Colella C. 2011: A critical reconsideration of biomedical and veterinary applications of natural zeolites. Clay Miner. 46 295—309. DOI: 10.1180/claymin.2011.046.2.295.

  • 4. Ghasemi Z. Sourinejad I. Kazemian H. Rohani S. 2016: Application of zeolites in aquaculture industry: a review. Rev. Aquaculture 10 75—95. DOI: 10.1111/raq.12148.

  • 5. Hampson D. J. 1986: Influence of creep feeding and dietary intake after weaning on malabsorption and occurrence of diarrhoea in newly weaned pig. Research in Veterinary Science 41 1 63–69.

  • 6. Mackinnon J. D. 2015: Differential Diagnosis of Post-weaning Diarrhoea in Pigs. https://www.pig333.com/articles/differential-diagnosis-of-post-weaning-diarrhoea-in-pigs_10484/.

  • 7. Mastinu A. Kumar A. Maccarinelli G. Bonini S. A. Premoli M. Aria F. et al. 2019: Zeolite clinoptilolite: Therapeutic virtues of an ancient mineral. Molecules 24 8. DOI: 10.3390/molecules24081517.

  • 8. Nabuurs M. J. A. 1991: Etiologic and Pathogenic Studies on Postweaning Diarrhoea. PhD. Thesis State University of Utrecht Centraal Diergeneeskundig Instituut. Lelystad the Netherlands 131 pp.

  • 9. Nabuurs M. J. A. Hoogendoorn A. Van Der Molen E. J. Osta A. L. M. 1993: Villus height and crypt depth in weaned and unweaned pigs reared under various circumstances in the Netherlands. Res. Vet. Sci. 55 78—84.

  • 10. Nakaue H. S. Koelliker J. K. 1981: Studies with clinoptilolite in poultry. I. Effect of feeding varying levels of clinoptilolite (zeolite) to dwarf Single Comb White Leghorn pullets and ammonia production. Poult. Sci. 60 944—949. DOI: 10.3382/ps.0600944.

  • 11. Ouhida I. Pérez J. F. Piedrafita J. Gasa J. 2000: The effects of sepiolite in broiler chicken diets of high medium and low viscosity. Productive performance and nutritive value. Anim. Feed Sci. Technol. 85 183—194. DOI: 10.1016/S0377-8401(00)00148-6

  • 12. Papaioannou D. S. Kyriakis C. S. Alexopoulos C. Tzika E. D. Polizopoulou Z. S. Kyriakis S. C. 2004: A field study on the effect of the dietary use of a clinoptilolite-rich tuff alone or in combination with certain antimicrobials on the health status and performance of weaned growing and finishing pigs. Res. Vet. Sci. 76 1 19—29. DOI: 10.1016/j.rvsc.2003.08.006.

  • 13. Papaioannou D. Katsoulos P. D. Panousis N. Karatzias H. 2005: The role of natural and synthetic zeolites as feed additives on the prevention and/or the treatment of certain farm animal diseases: A review. Microporous Mesoporous Mater. 84 161—170. DOI: 10.1016/j.micromeso.2005.05.030.

  • 14. Powell D. W. 1987: Intestinal water and electrolyte transport. In Johnson J. R. (Ed.): Physiology of the Gastrointestinal Tract 2nd edn. Raven Press New York. 1267—1305.

  • 15. Prvulović D. Jovanović-Galović A. Stanić B. Popović1 M. Grubor-Lajšić G. 2007: Effects of a clinoptilolite supplement in pig diets on performance and serum parameters. Czech J. Anim. Sci. 52 6 159—164. DOI: 10.17221/2317-CJAS.

  • 16. Ramos A. J. Fink-Gremmels J. Hernandez E. 1996: Prevention of toxic effects of mycotoxins by means of nonnutritive adsorbent compounds. J. Food Prot. 59 631—641.

  • 17. Reháková M. Čuvanová S. Dzivák M. Rimár J. Gavaľová Z. 2004: Agricultural and agrochemical uses of natural zeolite of the clinoptilolite type. Curr. Opin. Solid State Mater. Sci. 8 6 397—404. DOI:10.1016/j.cossms.2005.04.004.

  • 18. Sabater-Vilar M. Malekinejad H. Selman M. H. J. Van Der Doelen M. A. M. Johanna FinkGremmels J. 2007: In vitro assessment of adsorbents aiming to prevent deoxynivalenol and zearalenone mycotoxicoses. Mycopathologia 163 81—90. DOI: 10.1007/s11046-007-0093-6.

  • 19. Sabet F. A. Libre N. A. Shekarchi M. 2013: Mechanical and durability properties of self-consolidating high performance concrete incorporating natural zeolite silica fume and fly ash. Construct. Building Mat. 44 175—84. DOI: 10.1016/j.conbuildmat.2013.02.069.

  • 20. Shurson G. C. Ku P. K. Miller E. R. Yokoyama M. T. 1984: Effects of zeolite A or clinoptilolite in diets of growing swine. J. Anim. Sci. 59 1536—1545.

  • 21. Šperanda M. Liker B. Šperanda T. Šerić V. Antunović Z. Grabarević Ž. et al. 2006: Haematological and biochemical parameters of weaned piglets fed on fodder mixture contaminated by zearalenone with addition of clinoptilolite. Acta Vet. (Beograd) 56 121—136. DOI: 10.2298/AVB0603121S.

  • 22. Straková E. Suchý P. Herzig I. Šerman V. Mas N. 2008: The long-term administration of a clinoptilolite-supplemented feed to layers and its effect on performance haematological parameters and metabolic profile. Czech J. Anim. Sci. 53 5 212—218. DOI: 10.17221/311-CJAS.

  • 23. Subramaniam M. D. Kim I. H. 2015: Clays as dietary supplements for swine: A review. J. Anim. Sci. Biotechnol.. 6 1 38. DOI: 10.1186/s40104-015-0037-9.

  • 24. Thieu N. Q. Ogle B. Pettersson H. 2008: Efficacy of bentonite clay in ameliorating aflatoxicosis in piglets fed aflatoxin contaminated diets. Trop. Anim. Health Prod. 40 649—656. DOI:10.1007/s11250-008-9144-3.

  • 25. Valpotic H. Terzic S. Vince S. Samardzija M. Turk R. Lackovic G. et al. 2016: In-feed supplementation of a clinoptilolite favorably modulates intestinal and systemic immunity and some production parameters in weaned pigs. Vet. Med. 61 317—327. DOI: 10.17221/175/2015-VETMED.

  • 26. Valpotić H. Barić-Rafaj R. Mrljak V. Grabarević Ž. Samardžija M. Šperanda M. et al. 2017: Influence of dietary mannan oligosaccharide and clinoptilolite on hematological biochemical and gut histological parameters in weaned pigs. Period. Biol. 119 63—73. DOI: 10.18054/pb.v119i1.4407.

  • 27. Vente-Spreeuwenberg M. A. M. Verdonk J. M. A. J. Beynen A. C. Verstegen M. W. A. 2003: Interrelationships between gut morphology and faeces consistency in newly weaned pig-lets. J. Anim. Sci. 77 85—94.

  • 28. Vrzgula L. Sokol J. 1990: Interpretation of haematological profile (in Slovak). In Vrzgula L. et al. (Ed.): Disorders of Metabolism of Domestic Animals and their Prevention 470—472.

  • 29. Wawrzyniak A. Kapica M. Stępień-Pyśniak D. Szewerniak R. Olejarska A. Jarosz Ł. 2017: Effect of feeding transcarpathian zeolite on gastrointestinal morphology and function in broiler chickens. Brazilian Journal of Poultry Science 19 4 737—746.

  • 30. Wu Q. J. Wang L. C. Zhou Y. M. Zhang J. F. Wang T. 2013: Effects of clinoptilolite and modified clinoptilolite on the growth performance intestinal microflora and gut parameters of broilers. Poult. Sci. 92 684—692.

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