Skin wounds are a common presentation in small animal practice. These wounds may be acute or chronic with a complicated healing process. An important aspect of the healing of wounds is debridement which may be carried out by surgical, autolytic, mechanical or enzymatic methods. The debridement method is chosen according to the individual skin defect and influenced by factors such as wound size and location, the age of the wound, and the presence of infection or exudate. Enzymatic debridement is a method that is not commonly used in veterinary practice, and involves the use of enzyme preparations to remove necrotic tissue from a wound. The aim of this study was to investigate the effects of the enzymatic ointment collagenase as a method of debridement, and its effect on the macroscopic appearance of chronic skin wounds in cats and dogs. We observed that the application of Iruxol Mono directly to the wound changes the progress of the healing process, with no obvious adverse effects. The time of healing of chronic wounds was decreased and healthy granulation tissue was developed within a couple of days after application of the ointment. Enzymatic debridement appears to be a promising method of debridement for use in chronic wounds, and should be considered in cases where more conventional methods of debridement are ineffective or unsuitable.
1. Falanga, V., 2002: Wound bed preparation and the role of enzymes: a case for multiple actions of therapeutic agents. Wounds, 14, 47—57.
2. Gokoo, C., 2009: A primer on wound bed preparation. Journal of the American College of Certified Wound Specialists, 1, 35—39.
3. Hummel, R. P., Kautz, P. D., MacMillan, B. G., Altmeier, W. A., 1974: The continuing problem of sepsis following enzymatic debridement of burns. Journal of Trauma, 14, 572—579.
4. Langer, V., Bhandari, P. S., Rajagopalan, S., Mukherjee, M. K., 2013: Enzymatic debridement of large burn wounds with papain-urea: Is it safe ? Medical Journal Armed Forces India, 69, 144—150.
5. Marazzi, M., Stefani, A., Chiaratti, A., Ordanini, M. N., Falcone, L., Rapisarda, V., 2006: Effect of enzymatic debridement with collagenase on acute and hard-to-heal wounds. Journal of Wound Care, 15, 222—227.
6. Onesti, M. G., Fioramonti, P., Fino, P., Sorvillo, V., Carella, S., Scuderi, N., 2015: Effect of enzymatic debridement with two different collagenases versus mechanical debridement on chronic hard-to-heal wounds. International Wound Journal, 1742, 1—5.
7. Payne, W. G., Salas, R. E., Ko, F., Naidu, D. K., Donate, G., Wright, T. E., Robson, M. C., 2008: Enzymatic debriding agents are safe in wounds with high bacterial bioburdens and stimulate healing. Journal of Plastic Surgery, 8, 151—156.
8. Ramundo, J., Gray, M., 2009: Collagenase for enzymatic debridement: a systematic review. Journal of Wound Ostomy and Continence Nursing, 36, 411.
9. Tobias, K., Johnston, S., 2012: Veterinary Surgery: Small Animal. Elsevier Saunders, Philadelphia, 2352 pp.