Analgesic Effect of Tramadol and Buprenorphin in Continuous Propofol Anaesthesia

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Abstract

The objective of this study was to compare in clinical patients the analgesic effect of the centrally acting analgesics tramadol and buprenorphine in continuous intravenous anaesthesia (TIVA) with propofol. Twenty dogs undergoing prophylactic dental treatment, aged 2−7 years, weighing 6−27 kg, were included in ASA I. and II. groups. Two groups of dogs received intravenous (IV) administration of tramadol hydrochloride (2 mg.kg−1) or buprenorphine hydrochloride (0.2 mg.kg−1) 30 minutes prior to sedation, provided by midazolam hydrochloride (0.3 mg.kg−1) and xylazine hydrochloride (0.5 mg.kg-1) IV. General anaesthesia was induced by propofol (2 mg.kg−1) and maintained by a 120 minutes propofol infusion (0.2 mg.kg−1min−1). Oscilometric arterial blood pressure (ABP) measured in mm Hg, heart rate (HR), respiratory rate (RR), SAT, body temperature (BT) and pain reaction elicited by haemostat forceps pressure at the digit were recorded in ten minute intervals. The tramadol group of dogs showed significantly better parameters of blood pressure (P < 0.001), lower tendency to bradycardia (P < 0.05), and better respiratory rate (P < 0.001) without negative influence to oxygen saturation. Statistically better analgesia was achieved in the tramadol group (P < 0.001). Tramadol, in comparison with buprenorphine provided significantly better results with respect to the degree of analgesia, as well as the tendency of complications arising during anaesthesia.

References

  • 1. Bono, A. V., Cuffari, S., 1997: Effectiveness and tolerance of tramadol in cancer pain. A comparative study with respect to buprenorphine. Drugs, 53 Suppl. 2, 40-49.

  • 2. Budd, K., Raffa, R. B., 2005: Buprenorphine - The unique opioid analgesic. Georg Thieme Verlag, Stuttgart, 3-21.

  • 3. Brayfield, A., 2013: “Tramadol Hydrochloride”. Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved April 5th, 2014, https://en.wikipedia.org/wiki/Tramadol.

  • 4. Brema, F., Pastorino, G., Martini, M. C., Gottlieb, A., Luzzani, M., Libretti, A., Sacca, L., Gigolari, S., 1996: Oral tramadol and buprenorphine in tumour pain. An Italian multicentre trial. Int. J. Clin. Pharmacol., 16, 109-116.

  • 5. Duthie. D. J. R., 1998: Remifentanil and tramadol: recent advances in opioid pharmacology. Br. J. Anaesth., 81, 51-57.

  • 6. Kögel, B., Terlinden, R., Schneider, J., 2014: Characterisation of tramadol, morphine and tapentadol in an acute pain model in Beagle dogs. Vet. Anaesth. Analg., 41, 297-304.

  • 7. Mastrocinque, S., Fantoni, D. T., 2003: A comparison of preoperative tramadol and morphine for the control of early postoperative pain in canine ovariohysterectomy. Vet. Anaesth. Analg., 30, 220-228.

  • 8. Moody, D. E., Fang Lin, S. N., Weyant, D. M., Strom, S. C., Omiecinski, C. J., 2009: Effect of Rifampin and Nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes. Drug Metab. Dispos., 37, 2323-2329.

  • 9. Paul-Murphy, J. R., Brunson, D. B., Miletic, V., 1999: Analgesic effects of butorphanol and buprenorphine in conscious African grey parrots (Psittacus erithacus and Psittacus erithacus timneh). Am. J. Vet. Res., 60, 1218-1221.

  • 10. Reimann, W., Schneider, F., 1998: Induction of 5-hydroxytryptamine release by tramadol, fenfluramine and reserpine. European Journal of Pharmacology, 349, 199-203.

  • 11. Rhoda Lee, C., McTavish, D., Sorkin, E. M., 1993: Tramadol. Drugs, 46, Suppl. 2, 313-340.

  • 12. Rossi, S., 2013: Australian Medicines Handbook. 2013 edn.. The Australian Medicines Handbook Unit Trust, Adelaide, 965 pp.

  • 13. Roughan, J. V., Flecknell, P. A., 2002: Buprenorphine: a reappraisal of its antinociceptive effects and therapeutic use in alleviating post-operative pain in animals. Lab. Anim., 36, 322-343.

  • 14. Taylor, P. M., Houlton, J. E. F., 1984: Postoperative analgesia in the dog - a comparison of morphine, buprenorphine and pentazocine. J. Small Anim. Pract., 25, 437-451.

  • 15. Unlugenc, H., Ozalevli, M., Gunes, Y., Guler, T., Isik, G., 2003: Pre-emptive analgesic efficacy of tramadol compared with morphine after major abdominal surgery. Br. J. Anaesth., 91, 209-213.

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