Basic Roles of Sex Steroid Hormones in Wound Repair with Focus on Estrogens (A Review)

Open access

Abstract

Previously, it has been shown that sex hormones, in particular estrogens, play an important role in the regulation of biological processes involved in tissue repair and regeneration. Accordingly, several studies have supported the beneficial properties of hormone replacement therapies (HRT) in postmenopausal models. The present review paper explores the potential for targeted sex steroid HRT as a new therapeutic option for the surgical management of wounds in postmenopausal women and animals.

1. Anaya, D. A., Dellinger, E. P., 2006: The obese surgical patient: a susceptible host for infection. Surg. Infect. (Larchmt), 7, 473-480.

2. Anderson, G. L., Limacher, M., Assaf, A. R., Bassford, T., Beresford, S. A., Black H. et al., 2004: Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA, 291, 1701-1712.

3. Angele, M. K., Catania, R. A., Ayala, A., Cioffi, W. G., Bland, K. I., Chaudry, I. H., 1998: Dehydroepiandrosterone: An inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced haemorrhage. Arch. Surg., 133, 1281-1288.

4. Araneo, B. A., Ryu, S. Y., Barton, S., Daynes, R. A., 1995: Dehydroepiandrosterone reduces progressive dermal ischemia caused by thermal injury. J. Surg. Res., 59, 250-262.

5. Arvat, E., Di Vito, L., Lanfranco, F., Maccario, M., Baffoni, C., Rossetto, R. et al., 2000: Stimulatory effect of adrenocorticotropin on cortisol, aldosterone, and dehydroepiandrosterone secretion in normal humans: dose-response study. J. Clin. Endocrinol. Metab., 85, 3141-3146.

6. Ashcroft, G. S., Dodsworth, J., van Boxtel, E., Tarnuzzer, R. W., Horan, M. A., Schultz, G. S. et al., 1997: Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels. Nat. Med. 3, 1209-1215.

7. Ashcroft, G. S., Mills, S. J. 2002: Androgen receptor mediated inhibition of cutaneous wound healing. J. Clin. Invest., 110, 615-624.

8. Ashcroft, G. S., Mills, S. J., Lei, K., Gibbons, L., Jeong, M. J., Taniguchi, M. et al., 2003: Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J. Clin. Invest., 111, 1309-1318.

9. Ashworth, J. J., Smyth, J. V., Pendleton, N., Horan, M., Payton, A., Worthington, J. et al., 2005: The dinucleotide (CA) repeat polymorphism of estrogen receptor beta but not the dinucleotide (TA) repeat polymorphism of estrogen receptor alpha is associated with venous ulceration. J. Steroid Biochem. Mol. Biol., 97, 266-270.

10. Emmerson, E., Campbell, L., Ashcroft, G. S., Hardman, M. J., 2010: The phytoestrogen genistein promotes wound healing by multiple independent mechanisms. Mol. Cell Endocrinol., 321, 184-193.

11. Gantwerker, E. A., Hom, D. B., 2011: Skin: histology and physiology of wound healing. Facial Plast. Surg. Clin. North Am., 19, 441-453.

12. Gilliver, S. C., Ashworth, J. J., Mills, S. J., Hardman, M. J., Ashcroft, G. S., 2006: Androgens modulate the inflammatory response during acute wound healing. J. Cell Sci. 119, Pt 4, 722-732.

13. Gilliver, S. C., Emmerson, E., Campbel, L., Chambon, P., Hardman, M. J., Ashcroft, S. G., 2010: 17β-estradiol inhibits wound healing in male mice via estrogen receptor-α. Am. J. Pathol., 176, 2707-2721.

14. Gosain, A., DiPietro, L. A., 2004: Aging and wound healing. World J. Surg., 28, 321-326.

15. Guo, S., DiPietro, L. A., 2010: Factors affecting wound healing. J. Dent. Res., 89, 219-229.

16. Hardman, M. J., Ashcroft, G. S., 2008: Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly. Genome Biol., 9, 1-17. doi:10.1186/gb-2008-9-5-r80, http://genomebiology.com/2008/9/5/R80.

17. Hardman, M. J., Emmerson, E., Campbell, L., Ashcroft, G. S., 2008: Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice. Endocrinology, 149, 551-557.

18. Holcomb, V. B., Keck, V. A., Barret, J. C., Hong, J., Libtti, S. K., Nunez, N. P., 2009: Obesity impairs wound healing in ovariectomized female mice. In vivo, 23, 515-518.

19. Labrie, F., Belanger, A., Cusan, L., Gomez, J. L., Candas, B., 1997: Marked decline in serum concentrations of adrenal c19 sex steroid precursors and conjugated androgen metabolites during aging. J. Clin. Endocrinol. Metab., 82, 2396-2402.

20. Labrie, F., Belanger, A., Luu-The, V., Labrie, C., Simard, J., Cusan, L. et al., 1998: DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: Its role during aging. Steroids, 63, 322-328.

21. Labrie, F., Luu-The, V., Lin, S. X., Simard, J., Labrie, C., El-Alfy, M. et al., 2000: Intracrinology: role of the family of 17-β hydroxysteroid dehydrogenases in human physiology and disease. Journal of Molecular Endocrinology, 25, 1-16.

22. Lemieux, C., Picard, F., Labrie, F., Richard, D., Deshaies, Y., 2003: The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity. Obes. Res. 11, 477-490.

23. Li, J., Chen, J., Kirsner, R., 2007: Pathophysiology of acute wound healing. Clinics in Dermatology, 25, 9-18.

24. Margolis, D. J., Knauss, J., Bilker, W., 2002: Hormone replacement therapy and prevention of pressure ulcers and venous leg ulcers. Lancet, 359, 675- 677.

25. Mathieu, D., Linke, J. C., Wattel, F., 2006: Non-healing wounds. In Mathieu, D. E. (Ed.): Handbook on Hyperbaric Medicine, Netherlands: Springer, 401-427.

26. Mills, S. J., Ashworth, J. J., Gilliver, S. C., Hardman, M. J., Aschcroft, G. S., 2005: The sex steroid precursor DHEA accelerates cutaneous wound healing via the estrogen receptors. J. Invest. Dermatol., 125, 1053-1062.

27. Pavletic, M. M., 2010: Basic principles of wound healing. In Atlas of Small Animal Wound Management and Reconstructive Surgery, 3rd edn., Wiley-Blackwell, 17-29.

28. Pelletier, G., Ren, L., 2004: Localization of sex steroid receptors in human skin. Histol. Histopathol., 19, 629-636.

29. Pospíšilová, A., 2011: New views on healing and treatment of wounds (In Czech). Practicus, 10, 27-30.

30. Prentice, R. L., Manson, J. E., Langer, R. D., Anderson, G. L., Pettinger, M., Jackson, R. D. et al., 2009: Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause. Am. J. Epidemiol., 170, 12-23.

31. Punjabi, U., Deslypere, J. P., Verdonck,. L, Vermeulen, A., 1983: Androgen and precursor levels in serum and testes of adult rats under basal conditions and after HCG stimulation. J. Steroid Biochem., 19, 1481-1490.

32. Rajabi, M. A., Rajabi, F., 2007: The effect of estrogen on wound healing in rats: 2007. Pak. J. Med. Sci., 23, 349-352.

33. Robson, M. C., Steed, D. L., Franz, M. G., 2001: Wound healing: biologic features and approaches to maximize healing trajectories. Curr. Probl. Surg., 38, 72-140.

34. Velnar, T., Bailey, T., Smrkoj, V., 2009: The wound healing process: an overview of the cellular and molecular mechanism. Journal of International Medical Research, 37, 1528-1542.

35. Wang, S. B., Hu, K. M., Seamon, K. J., Mani, V., Chen, Y., Gronert, K., 2012: Estrogen negatively regulates epithelial wound healing and protective lipid mediator circuits in the cornea. The FASEB Journal, 26, 1506-1516.

36. Wu, J., Wang, X., Chiba, H., Higuchi, M., Nakatani, T., Ezaki, O. et al., 2004: Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice. Metabolism, 53, 942-948.

Journal Information

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 107 107 16
PDF Downloads 35 35 5