Folia Medica

The Journal of Medical University-Plovdiv

Open access

Thematic scope from fields - medicine, dentistry, pharmacy, public health and health care. Priority themes: etiological, molecular genetic, pathogenic, experimental, clinical and therapeutic aspects of socially significant diseases (cardiovascular, cerebrovascular, diabetes, neoplastic diseases, etc..), Reconstructive dentistry, Integrative Biology, Nutrgenomic, Ecology and Health.

AIM: The magazine would continue to be solid and prestigious opportunity to promote reputable Bulgarian and European scientists. Articles with its variety of different sections of medicine / endocrinology, cardiology, pulmonology, gastroenterology, nephrology, rheumatology, surgery, orthopedics, urology, otorhinolaryngology, dermatology, ophthalmology, preventive medicine, maxillofacial surgery, medical genetics, etc. / dental, pharmacy, public health researchers to present their achievements in research and innovative diagnostic and therapeutic approaches in modern science. His journals in English and distribution in 33 countries around the world enables thousands of physicians and scientists to know the problems treated in it.

The general editorial policy is to optimize the process of issuing and distribution of Folia medica in line with modern standards for current and active visible scientific periodicals - such as content, form, function. By raising the quality of Folia medica to give response to the broad scientific achievements of the Bulgarian academic and scientific community.

Folia Medica is a peer-reviewed medical journal, published quarterly by Plovdiv Medical University in paper version. It is issued exclusively in English publishing review articles, original research papers, rapid communications, brief reports, case reports, and letters to the editor by Bulgarian and foreign authors. Received manuscripts are accepted for publication only after they have been rigorously reviewed by independent experts in the respective fields, the reviewers remaining anonymous to the authors. The journal is published under the strict supervision of an Editorial Board which consists of: Editor-In-Chief, Deputy Editor-In-Chief, Science Editors and Members - 33 Bulgarian and 13 foreign members (USA, Russia, France, Germany, Spain, Belgium, Greece) who are all Doctors of Medical Sciences.

Scope - the journal accepts materials in the following fields: medicine, dental medicine, pharmacology, public health and health care. Priority topics include: etiology, molecular genetics, pathogenetics, experimental medicine, clinical and therapeutic aspects of socially significant diseases (cardiovascular diseases, cerebrovascular diseases, diabetes mellitus, neoplastic disorders, etc), ecology and health, reconstructive dentistry, integrative biology.

All published articles are in full compliance with the current Uniform Requirements for Manuscripts Submitted to Biomedical Journals.

Similarity Check Plagiarism Screening System

The editorial board is participating in a growing community of Similarity Check System's users in order to ensure that the content published is original and trustworthy. Similarity Check is a medium that allows for comprehensive manuscripts screening, aimed to eliminate plagiarism and provide a high standard and quality peer-review process.

Detailed description of the Similarity Check System can be found at:

Supplementary Materials

Abstracting & Indexing

Folia Medica is covered by the following services:

  • Baidu Scholar
  • Cabell's Whitelist
  • Case
  • Chemical Abstracts Service (CAS) - CAplus
  • Chemical Abstracts Service (CAS) - SciFinder
  • CNKI Scholar (China National Knowledge Infrastructure)
  • CNPIEC - cnpLINKer
  • Dimensions
  • DOAJ (Directory of Open Access Journals)
  • EBSCO (relevant databases)
  • EBSCO Discovery Service
  • Genamics JournalSeek
  • Google Scholar
  • Japan Science and Technology Agency (JST)
  • J-Gate
  • JournalGuide
  • JournalTOCs
  • KESLI-NDSL (Korean National Discovery for Science Leaders)
  • Medline
  • Meta
  • Microsoft Academic
  • MyScienceWork
  • Naver Academic
  • Naviga (Softweco)
  • Primo Central (ExLibris)
  • Publons
  • PubMed
  • QOAM (Quality Open Access Market)
  • ReadCube
  • SCImago (SJR)
  • Semantic Scholar
  • Sherpa/RoMEO
  • Summon (ProQuest)
  • TDNet
  • Ulrich's Periodicals Directory/ulrichsweb
  • WanFang Data
  • WorldCat (OCLC)

Instructions for authors

FOLIA MEDlCA, which began publication in 1959, is double-blind peer-reviewed official journal or the Medical University in Plovdiv, It is published quarterly in English giving high priority to contributions of the medical staff of the Medical University.Ccontributions of authors from other medical establishments in and abroad can also be considered for publication.

The materials are submitted to the Editorial Office in with the signatures of all authors on the last page of the manuscript. A cover letter must be enclosed separately giving the full name of the corresponding author and providing this author's complete address, telephone and fax numbers, and e-mail address. The latter should coordinate the suggested review corrections with the co-authors.

Each author is required to attest in written in a Submission Form that the manuscript is not under simultaneous consideration by another publication at the time of its submission, and that it has not been published elsewhere either in print or electronic format. The submission or the manuscript by the authors means that the authors automatically agree to assign exclusive copyright to FOLIA MEDICA if and when the manuscript is accepted for publication. The materials and the procedures used in the study should be in conformity with the established ethical criteria concerning studies involving human beings or No patient should be referred to by a name,initials or photographs by which idenWication or the person be done. Authors are responsibJe for all statements, opinions, conclusions, and methods or presenting their data in the materials.

All submissions are assigned to a review process by expert referees to determine the originality, validity, and to the field or their content and conclusions and then ac· cepted for upon approval by the Editorial Board.

The journal does not have article processing charges (APCs) nor article submission charges

Editorial Office:

Library & Center
Medical University 15A Vassil Aprilov Street
Plovdiv 4002
leL+359 32/602 588

Requirements for the submission of manuscripts

These have been revised in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals," (N Engl J Med 1997,336: 309-315.) Submissions in the following categories will he deemed appropriate for consideration by the Edi· tors and Editorial Board or FOLIA MEDICA:

Review articles and special articles these should not exceed 12 standard-sized double-spaced pages, including tables, figures and text appended to them. The review articles should include Introduction, the remaining sections being given headings by the authors. The and References (no more than 25 references) sections are separately.

Original articles - up to 10 standard sized double-spaced pages, including tables, figures, and accompanying text. The Abstract and References (no more than 20 references) sections are submitted separately. The sections in the articles are: Materials and Methods; Results; Discussion and Conclusions.

Short Communications - these should be no more than 4 standard-sized double-spaced pages including tables, figures and accompanying text. The Abstract and References (no more than 20 references) sections are submitted separately. The format is identical to that or a article with the following sections bearing a heading: Introduction (with the aim of the communication clearly stated); Materials and Methods; Results and Discussion; Conclusions.

Case Reports - these are to 3 standard·sized double-spaced pages including tables, figures and iIIustrations. The Abstract and References (no more than 8 references) sections are submitted separately to the Editor - these include comments arising from recent articles published in the FOLIA MEDICA, or discussions on topical problems. They should be short, up to 2 standard sized double-spaced pages including references (no more than 5 references). The authors are req uired to e-mail or submit by post two copies of the originaJ manuscri pt, the tables and figures accompanying the text and a 3.5"·disk containing the manuscript. The abstract is in two copies separately from the manuscri pt.

Technical Requirements and Preparation of the Manuscript

  • All manuscripts must be either typewritten ar printed on one side ar white bond paper (A4,212 x 297 mm). Allow margins or at least 25 mm on alI sides or the typed pages. Papers should be double-spaced throughout in 30 lines and 60 charaders per line. Number manuscript pages consecutively throughout the paper beginning with the title page. If the hard copy is printer generated, use only 12-point fant size or the letters. The copies should cantain no smudges ar peneil ar pen marks. Manuscri pts wfitten in block type fant will be rejected.
  • The first (title) page of the paper should carry the following obligatory sections: Title, no abbreviations Authors' names full first and family name, and middle initial Names or the Department(s) and Institution(s) with which the authors are currently affiliated. Indicate by an asterisk the institutions other these if the research was performed in them.
  • Acknowledgements Individuals with direct involvement in the study but not included in authorship, collaboration or preparation, financial or material support may be acknowledged. Authors are responsible for obtaining written permission from persons acknowledged by name.

ABSTRACT. Authors submitting manuscri pts should prepare an abstract of no more than 250 words under the following headings: Objective, Methods, Results, and Conclusions. They should brierty describe the problem being addressed in the how the study was performed, the sali ent results, and what the authors conelude from the results. The abstract shouJd be on a separate page. Do not include the institutional affiliation or authors. Abbreviations should be avoided in the abstract. Include up to 5 key words or phrases for subject indexing (use terms from the Medical Subject Headings from Index Medicus).

FIGURES. figures should be designed and photographed; freehand or type written lettering is unacceptable. Send sharp, glossy,black-and-white photographic prints usually 90x 120 mm or 127x 178 mm (5x7 in.). Figures should be numbered consecutively according to the order in which they have been first cited in the text and the numbers should be given in the left-hand margin (e.g., Fig. I) when first cited. Letters, numbers, and symbol s should be elear and even throughout and of sufficient size that when reduced for publication each Hem will still be legible. The back of each figure should include the seq uence number and the proper orientation (e.g., top). Each figure should be enclosed in an envelope with the author's name and the title. When symbols, arrows, numbers, or letters are used to identy parts of the illustra-tions, they should be marked on a transparency, attached to one side or the photograph. Titled and detailed explanations belong in the legends for illustrations,not on the illustrations themselves and these should be stated on a separate sheet at the end of the manuscript, entitled "Legends for illustrations".

TABLES. Type or print out each table with double spacing on a separate sheet of paper. Number tables consecutively in the order of their first citation in the text and give the number or the table in the left-hand margin. Supply a brief title for each. Give each column a short or abbreviated heading. Place ex pIana tory mat-ter in footnotes, not in the heading. Explain in footnotes all non-standard abbreviations that are used in each table.

STATISTICS.All data must be analyzed statistically. Detailed statistical methodology must be reported. Describe randomization procedures. Describe the specific tests used to examine each part or the results. Care should be taken with respect to a) parametric vs. non-parametric data, b) correetions for multi ple eomparisons, and e) rounding errors (summary statistics should not contain more significant digits the original data). Variability should be expressed either as median and range (or percentiles) for nonpara-metric data,or mean ± standard error, standard deviation (or confidence intervals) for normally distributed data. Traditionally FOLIA MEDlCA uses the following symbols: X±SX (for mean and standard error) and Sx (for standard deviation).

UNITS OF MEASUREMENT.Ali measurements should be reported in aeeordanee with the International System or Units (SI).

Use only standard abbreviations. Avoid abbreviations in title and abstract. The full term for which an abbreviation stands should preeede its first use in the text unless it is a standard unit or measurement.

REFERENCES.References should be num-bered in the order in which they are first mentioned in the text (not alphabetically). Identify references in the text, tables, and legends by Arabie numerais in parentheses.

ARTICLES IN JOURNALS.List all authors when they are three ar fewer; when there are more than three,list the first three, folIowed by "et al". The names of all authors are cited in inverted order - first the family name in fuli folIowed by the author's initials without dots between them. The journal names are given in the abbreviated form in the style used in lndex Medieus, folIowed by the year of publieation, volume number, the month and issue number and inclusive page numbers.
Example: Parki n DM, Clayton D, Blaek RJ, Masuyer E, FriedJ HP, lvanov E, et al. Childhoodleukaemia in Europe after Chernobyl: 5 year follow-up. Br J Cancer 1996:73: J 006- 12.

BOOKS AND OTHER MONOGRAPHS.List the name or the author(s), title, place or publieation, publisher and date.
Example: Kassirer JP, Kopelman RI. Learning clinical reasoning. Baltimor (MO): Williams & Wilkins;1991.

CHAPTERS IN A BOOK.List the name of the author, title, followed by In:, name of editor(s), place of publication, publisher, date and pages.
Example: Phillips SJ, Whisnant JP. Hypertensian and stroke. In: Laragh JH, Brenner BM, eds. Hypertensian: pathophysiology,diagnosis, and management. 2nd ed. New York: Raven Press; 1995:465·78.

DISSERTATION.List the name or author, title or dissertation, speeified in square braekets `dissertation`, the locale where the dissertation was written, the name or institution and year or writing.

Prof. Stefan Stoilov Kostianev, MD, PhD, DMSc (Head of Department of Pathophysiology Rector of Medical University – Plovdiv, Editor in Chief of Folia Medica)

Deputy Editor-in-chief
Prof. Victoria Stepan Sarafian-Ozanian, MD, PhD, DMSc (Vice Rector of R&D Head of Department of Medical Biology)

Managing Editor
Prof. B. I. Marinov, MD, PhD, DMSc
Prof. Blagovest Pehlivanov, MD, PhD, DMSc (Department of Ginecology)

Editorial Advisory Board
Prof. D. Getova-Spasova, MD, PhD, DMSc
Assoc. Prof. B. Anavi, MD, PhD

Statistical Advisor
Prof. M. Semerdjieva, MD, PhD, DMSc

Technical Editors
V. Gjulina,
dipl. eng. N. Atanasova

Prof. Mariana Atanasova Murdjeva, MD, PhD (Vice Rector of International Relations and Project Activity, Head of Department of Microbiology and Immunology)
Prof. Y. Anastassov, MD, PhD, DMSc
Prof. B. Chilova, MD, PhD, DMSc
Prof. S. Goranov, MD, PhD, DMSc
Prof. B. Hadjiev, MD, PhD
Prof. A. Krastev, PhD, DBSc
Prof. M. Kukleva, DD, PhD, DMSc
Prof. F. Nikolov, MD, PhD
Prof. R. Stefanov, MD, PhD
Prof. Ivan Stefanov Ivanov, MD, PhD (Head of Clinic of Pediatrics and Genetic Diseases)
Prof. Y. Stoilova, MD, PhD
Prof. M. Stoycheva, MD, PhD, DMSc
Prof. Stefan Todorov Sivkov, MD, PhD (Vice rector of Quality and Accreditation, Head of Department of Anatomy, Histology and Embriology)
Prof. A. Uchikov, MD, PhD, DMSc
Prof. K. Velkova, MD, PhD, DMSc
Prof. S. Vladimirov, DD, PhD
Prof. M. Yaneva, MD, PhD, DMSc
Prof. Z. Zahariev, MD, PhD, DMSc
Assoc. Prof. Nikolai Petrov Boyadjiev, MD, PhD (Dean of Faculty of Medicine, Head of Department of Physiology)
Assoc. Prof. C. Dobrev, MD, PhD
Assoc. Prof. C. Stefanov, MD, PhD
Assoc. Prof. E. Moshekov, MD, PhD
Assoc. Prof. G. Pascalev, MD, PhD
Assoc. Prof. G. Todorov, DD, PhD
Assoc. Prof. I. Koeva, MD, PhD
Assoc. Prof. M. Kasarova, DF, PhD
Assoc. Prof. Drozdstoy Stoyanov, MD, PhD (Department of Psychiatry and Medical Psychology)
Assoc. Prof. S. Tzanova, DD, PhD

International members
Prof. Andrew Miles, Msc, MPhil, PhD (London, UK)
Prof. Bernard Amor, MD, PhD, DMSc (Paris, France)
Prof. Constantinos Simopoulos, MD (Alexandroupolis, Greece)
Prof. Eberhard Wieland, MD, PhD, DMSc (Göttingen, Germany)
Prof. Emanuela Signori, PhD (Roma, Italy)
Prof. Francisco Soriano, MD, PhD (Madrid, Spain)
Prof. George Anastassov, MD, PhD, DDSc (NYC, USA)
Prof. Greg Skalkeas, MD, Academician (Athens, Greece)
Prof. Ingrid Kreissig, MD, PhD, DMSc (Mannheim, Germany)
Prof. John Christakis, MD (Thessaloniki, Greece)
Prof. John Kyriopoulos, MD, PhD, DMSc (Athens, Greece)
Prof. Jukka Meurman, MD, PhD, DOdont (Helsinki, Finland)
Prof. Konstantinos Kazakos, MD, PhD (Alexandroupolis, Greece)
Prof. Konstantinos Kouskoukis, MD (Alexandroupolis, Greece)
Prof. Lidia Benevolenscaya, MD (Moscow, Russia)
Prof. Michael Oellerich, MD, PhD, DMSc (Göttingen, Germany)
Prof. Mikhail Mikhailovsky, MD, PhD, DMSc (Novosibirsk, Russia)
Prof. Patrick Dhellemmes, MD, PhD (Lille, France)
Prof. Philippe Pellerin, MD, PhD (Lille, France)
Prof. Yves Poumay, PhD (Namur, Belgique)

Language Editor (English):
Assoc. Prof. O. Obretenov, PhD

Language Editor (Russian):
P. Kancheva
Folia Medica

MU, Library and Information Center,
V. Gjulina (e-mail:
15 A Vassil Aprilov St., 4002 Plovdiv, Bulgaria
Tel: +359 32 602 588,
Fax: +359 32 602 534

Bogumiła Zuga 32A Str.
01-811 Warsaw, Poland
T: +48 22 701 50 15