Chronic Obstructive Pulmonary Disease and Hepatitis C

Evgeni V. Mekov 1 , Rosen E. Petkov 1 , Dimitar T. Kostadinov 1 , Krasimir A. Antonov 2 ,  and Deian T. Jelev 2
  • 1 Clinical Center for Pulmonary Diseases, St. Sofia Hospital for Pulmonary Diseases, Medical University of Sofia, Sofia, Bulgaria
  • 2 Clinic of Gastroenterology, St. Ivan Rilski University Hospital, Medical University of Sofia, Sofia, Bulgaria


Chronic obstructive pulmonary disease (COPD) is a preventable, treatable disease with significant extrapulmonary manifestations that could affect negatively its course in some patients. Hepatitis C virus infection (HCV), on the other hand, is associated with a number of extrahepatic manifestations. COPD patients have increased prevalence of HCV and patients with HCV, especially older ones, have increased prevalence and faster progression of COPD. HCV infection exerts long-term effects on lung tissue and is an additional risk factor for the development of COPD. The presence of HCV is associated with an accelerated loss of lung function in COPD patients, especially in current smokers. COPD could represent extrahepatic manifestation associated with HCV infection. The aim of this article was to review the literature on prevalence of HCV in COPD and vice versa, pathogenetic link and the consequences of their mutual existence.

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