The paper presents the analysis of the functional abilities of measurement tools with ellipsoidal reflectors for Raman spectroscopy. The investigated structural scheme of the setup is intended for use in Raman spectroscopy in vivo by ellipsoidal reflectors. The setup can be used as a prototype for development of a device for non-invasive control of sugar level. Additionally, the investigation demonstrates the efficiency of ellipsoidal photometry method for registration of Raman scattering signal on test-solutions. The testing was performed for different sugar concentrations with the laser radiation wavelength 980 nm. In addition, the selecting principles of laser radiation source parameters (including beam diameter and power) were investigated. During the research, the data about spatial distribution of the backscattered light in human shoulder and finger tissues during photometry by ellipsoidal reflectors were received. The procedure involves application of Monte Carlo simulation. The dependency of the external and middle ring illuminance of photometric images on the diameter and power of the laser beam is represented based on the zone analysis.
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 A. M.-Jansen, Ch. A. Patil, and I. J. Pence, “Raman spectroscopy: from benchtop to bedside”, in Biomedical Photonics Handbook vol. II: Biomedical Diagnostics, T. Vo-Dinh Duke University Durham, North Carolina, USA: CRC Press, Taylor & Francis Group, 2015, pp. 759–803.
 D. Cialla, A. März, R. Böhme, F. Theil, K. Weber, M. Schmitt, and J. Popp, “Surface-enhanced Raman spectroscopy (SERS): Progress and trends”, Analytical and Bioanalytical Chemistry, vol. 403, no. 1, pp. 27–54, 2012. https://doi.org/10.1007/s00216-011-5631-x
 K. T. Schomacker, J. K. Frisoli, C. C. Compton, Th. J. Flotte, J. M. Richter, N. S. Nishioka, and Th. F. Deutsch, “Ultraviolet laser-induced fluorescence of colonic tissue: basic biology and diagnostic potential”, Lasers in surgery and medicine, vol, 12, no. 1, pp. 63–78, 1992. https://doi.org/10.1002/lsm.1900120111
 O. Masihzadeh, D. A. Ammar, M. Y. Kahook, and T. C. Lei, “Coherent Anti-Stokes Raman scattering (CARS) microscopy: A novel technique for imaging the retina”, Investigative Ophthalmology & Visual Science, 2013, vol. 54, no. 5, pp. 3094–3101. https://doi.org/10.1167/iovs.13-11642
 Ch.-Ch. Lin, M.-T. Kuo, and H.-Ch. Chang, “Review: Raman spectroscopy – A novel tool for noninvasive analysis of ocular surface fluid”, Journal of Medical and Biological Engineering, vol. 30, no. 6, pp. 343–354, 2010.
 A. Mahadevan-Jansen, M. G. Sowa, G. J. Puppels, Z. Gryczynski, T. Vo-Dinh, and J. R. Lakowicz, “Diagnosis of atherosclerosis in human carotid artery by FT-Raman spectroscopy: Principal Components Analysis algorithm”, Proceedings of SPIE The International Society for Optical Engineering, 2004, vol. 5321, pp. 205–211.
 P. Chen, A. Shen, X. Zhou, and J. Hu, “Bio-Raman spectroscopy: a potential clinical analytical method assisting in disease diagnosis”, Anal. Methods, no. 3, pp. 1257–1269, 2011. https://doi.org/10.1039/c1ay05039g
 K. Kong, C. A. Kendall, N. Stone, and I. Notingher, “Raman spectroscopy for medical diagnostics — From in-vitro biofluid assays to in-vivo cancer detection”, Advanced Drug Delivery Reviews, vol. 89, pp. 121–134, 2015. https://doi.org/10.1016/j.addr.2015.03.009
 S. Jeong, et al., “Fluorescence-Raman dual modal endoscopic system for multiplexed molecular diagnostics”, Scientific Reports, 2015, vol. 5, article 9455, pp. 1–9. https://doi.org/10.1038/srep09455
 A. M. K. Enejder, T.-W. Koo, J. Oh, M. Hunter, S. Sasic, and M. S. Feld, “Blood analysis by Raman spectroscopy”, Optics Letters, 2002, vol. 27, no. 22, pp. 204–206. https://doi.org/10.1364/OL.27.002004
 Sh. N. M. M. Nezhad, Z. Hozhabri, A. Haghparast, G. Karami, and P. Hejazi, “Optimization of parameters in 16-slice CT-scan protocols for Reduction of the Absorbed Dose”, Iran J Med Phys, 2014, vol. 11, no. 2 & 3, pp. 270–275.
 M. S. Wróbel, “Non-invasive blood glucose monitoring with Raman spectroscopy: prospects for device miniaturization”, IOP Conference Series: Materials Science and Engineering 012036, 2016, vol. 104. https://doi.org/10.1088/1757-899X/104/1/012036
 M. Bezuglyi, N. Bezuglaya, and A. Viruchenko, “On the possibility of ellipsoidal photometry and Monte Carlo simulation to spatial analysis of biological media”, Electronics and Nanotechnology, 2017 IEEE 37th International Conference on Electronics and Nanotechnology (ELNANO), pp. 321–324, 2017. https://doi.org/10.1109/ELNANO.2017.7939771
 M. A. Bezuglyi, N. V. Bezuglaya, and I. V. Helich, “Ray tracing in ellipsoidal reflectors for optical biometry of media,” Appl. Opt., 2017, vol. 56, no. 30, pp. 8520–8526. https://doi.org/10.1364/AO.56.008520
 M. Bezuglyi, N. Bezuglaya, O. Kuprii, and I. Yakovenko, “The noninvasive optical glucometer prototype with ellipsoidal reflectors,” 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON), 2018, pp. 1–4. https://doi.org/10.1109/RTUCON.2018.8659864
 M. Bezuglyi, N. Bezuglaya, and S. Kostuk, “Influence of laser beam profile on light scattering by human skin during photometry by ellipsoidal reflectors”, Devices and Methods of Measurements, 2018, vol. 9, no. 1, pp. 56–65. https://doi.org/10.21122/2220-9506-2018-9-1-56-65
 P. Bhandare, Y. Mendelson, R. A. Peura, et al., “Multivariate determination of glucose in whole blood using partial least-squares and artificial neural networks based on mid-infrared spectroscopy,” Appl. Spectroscopy, 1993, vol. 47, no. 8, pp. 1214–1221. https://doi.org/10.1366/0003702934067928
 I. V. Meglinski, A. N. Bashkatov, E. A. Genina, D. Yu. Churmacov, and V. V. Tuchin, “Study of the possibility of increasing the probing depth by the method of reflection confocal microscopy upon immersion clearing of near-surface human skin layers”, Quantum Electronics, 2002, vol. 32, no. 10, pp. 875–882. https://doi.org/10.1070/QE2002v032n10ABEH002309