Pharmacologically active fractions of Sideritis spp. and their use in inherited eye diseases

Andi Abeshi 1 , 2 , Vincenza Precone 3 , Tommaso Beccari 4 , Munis Dundar 5 , Benedetto Falsini 6  und Matteo Bertelli 3 , 7
  • 1 MAGI Balkans, , Tirana, Albania
  • 2 MAGI’S Lab, , Rovereto, Italy
  • 3 MAGI Euregio, , Bolzano, Italy
  • 4 Department of Pharmaceutical Sciences, University of Perugia, , Perugia, Italy
  • 5 Department of Medical Genetics, Erciyes University Medical School, , Kayseri, Turkey
  • 6 Department of Ophthalmology, Catholic University of Rome, , Rome, Italy
  • 7 MAGI’S Lab, , Rovereto, Italy


The main constituents of the genus Sideritis are various terpenoids, sterols, coumarins, flavonoid aglycones and glycosides. Sideritis species have been traditionally used as infusions or flavoring agents and in medicine as anti-inflammatory, antiulcer, antimicrobial, antioxidant, antispasmodic and analgesic agents. This paper includes the following sections: Introduction, Description and distribution of Sideritis spp, Pharmacological effects, Toxicity tests, Rationale for use of Sideritis spp. in ophthalmology and Conclusions. The aim is to provide a comprehensive overview on the botanical, phytochemical and pharmacological aspects of the genus Sideritis, and to establish the scientific basis of its pharmacological use. New approaches to using officinal plants have recently yielded significant results. The paper also reviews this information and provides a critical view on the options for exploiting the potential of Sideritis spp. in ophthalmology.

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