Prosopis juliflora (mesquite) gum exudate as a potential excipient

Sweta Basu 1 , Majeti N.V. Prasad 2 , 3 , Sateesh Suthari 2  and Boda Ravi Kiran 2
  • 1 Department of Plant Sciences, School of Life Sciences, University of Hyderabad Central University P.O., Gachibowli, Hyderabad, , Telangana, India
  • 2 Department of Plant Sciences, School of Life Sciences, University of Hyderabad Central University P.O., Gachibowli, Hyderabad, , Telangana, India
  • 3 Present address: Visiting Professor School of Environment, Resources and Development (SERD), Room E120 Asian Institute of Technology (AIT) Klong Luang, , Pathumthani, Thailand

Abstract

Gum exudate was obtained from Prosopis juliflora (Sw.) DC., which is abundantly available in north-west, central, west and south India. It was analysed for its phytochemical composition in aqueous extract and as well as by LCMS, GCMS, TGDTA and SEM to validate it’s potential for use as an excipient (Fig. 1).

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Prasad MNV, Tewari JC. Prosopis juliflora (Sw.) DC.: Potential for bioremediation and bioeconomy. In: Prasad MNV (ed.), Bioremediation and Bioeconomy, USA: Elsevier2016; pp. 49-76.

  • 2. Jani GK, Shah DP, Prajapati VD, Jain VC. Gums and mucilages: versatile excipients for pharmaceutical formulations. Asian J Pharm Sci, 2009; 4(5), 309-323.

  • 3. Al-Humaid AI, Warrag MOA. Allelopathic effects of mesquite (Prosopis juliflora) foliage on seed germination and seedling growth of Bermuda grass (Cynodon dactylon). JArid Environ1998; 38(2): 237-243.

  • 4. Choudhary MI, Nawaz SA, Zaheer-Ul-Haq, Azim MK, Ghayur MN, Lodhi MA, Jali S, Khalid A, Ahmed A, Rode BM, Atta-Ur-Rahman, Gilani AH, Ahmad VU. Juliflorine: a potent natural peripheral anionic- site-binding inhibitor of acetylcholinesterase with calcium- channel blocking potential, a leading candidate for Alzheimer’s disease therapy. Biochem. BiophysResCommun2005; 332: 1171-1179.

  • 5. Beristain CI, García HS, Vernon-Carter EJ. Spray-dried encapsulation of cardamom (Elettaria cardamomum) essential oil with mesquite (Prosopis juliflora) gum. Lebensm WissTechnol 2001; 34: 398-401.

  • 6. Bhojvaid PP, Timmer VR. Soil dynamics in an age sequence of Prosopis julifloraplanted for sodic soil restoration in India. Forecol Manag1998;106: 181-193.

  • 7. Nagaraju A, Prasad KSS. Growth of Prosopis julifloraon pegmatite tailings from Nellore Mica Belt, Andhra Pradesh, India. Environ Geol 1998; 36: 320-324.

  • 8. Senthilkumar P, Prince WSPM, Sivakumar S, Subbhuraam CV. Prosopis juliflora, a green solution to decontaminate heavy metal (Cu and Cd) contaminated soils. Chemosphere 2005; 60: 1493-1496.

  • 9. Felker P, Bandurski RS. Uses and potential uses of leguminous trees for minimal energy input agriculture. EconBot1979; 33(2): 172-184.

  • 10. Goel VL, Behl HM. Fuelwood production potential of six Prosopis species on an alkaline soil site. Biomass Bioenergy 1995; 8: 17-20.

  • 11. Adikwu MU, Yoshikawa Y, Takada K. Bioadhesive delivery of metformin using prosopis gum with antidiabetic potential. Biol Pharm Bull2003; 26(5): 662-666.

  • 12. Vasile FE, Romero AM, Judis MA, Mazzobre MF. Prosopis alba exudate gum as excipient for improving fish oil stability in alginate- chitosan beads. Food Chem2016; 190: 1093-1101.

  • 13. Avachat AM, Dash RR, Shrotriya SN. Recent investigations of plant based natural gums, mucilages and resins in novel drug delivery systems. Ind J Pharm Edu Res 2011; 45(1): 86-99.

  • 14. Bhattacharyya L, Schuden S, Sheehan C, William R. Excipients: background introduction. In: Katdare A, Chaubal MV. (eds.), Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems. Informa healthcare, New York, London 2006; pp. 1-2.

  • 15. Calixto JB. Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents). Brazilian J Med Biol Res 2000; 33(2): 179-189.

  • 16. Saif, MMS, Kumar, NS and Prasad MNV. Plant-based excipients-the case of Strychnos potatorum seed polysaccharide nanoparticles. 2014; 11, 44-48.

  • 17. López-Franco YL, Córdova-Moreno RE, Goycoolea FM, Valdez MA, Juárez-Onofre J, Lizardi-Mendoza J. Classification and physicochemical characterization of mesquite gum (Prosopis spp.). Food Hydrocolloids 2012; 26(1): 159-166.

  • 18. Khandalwal KR, Sethi VK. Practical Pharmacognosy Techniques and Experiments. Nirali Prakashan, 4th edition 2014; pp. 1-25.

  • 19. Attama AA, Nnamani PO, Okorie O. Effect of pH and ionic strength on the bioadhesive properties of Prosopis africana gum. J Pharmacy Biores2005; 2(2): 141-145.

  • 20. Ovesen L, Bendtsen F, Tage-Jensen U, Pederson NT, Gram BR, Rune SJ. Intraluminal pH in the stomach, duodenum, and proximal jejunum in normal subjects and patients with exocrine pancreatic insufficiency. Gastroenterology 1986; 90(4): 958-962.

  • 21. Aspinall GO, Whitehead CC. Mesquite gum. II. The arabinan peripheral chains. Canadian JChem1970; 48(24): 3850-3855.

  • 22. FukuiM, KonnoY, KubotaY, ArugaM, KawataH. Solid drug preparations. U.S. Patent No. US 4380534A. 19 Apr. 1983.

  • 23. Prabha DS, Dahms H-U, Malliga P. Pharmacological potentials of phenolic compounds from Prosopis spp.-a review. J Coastal Life Med2014; 2(11): 918-924.

  • 24. López-Lazaro M. Distribution and biological activities of the flavonoid luteolin. Mini Rev MedChem2009; 9(1): 31-59.

  • 25. Ahmad VU, Sultana A. A terpenoiddiketone from the leaves of Prosopis juliflora. Phytochem1989; 28(1): 278-279.

  • 26. Leal LKAM, Costa MF, Pitombeira M, Barroso VM, Silveira ER, Canuto KM, Viana GSB. Mechanisms underlying the relaxation induced by isokaempferide from Amburanacearensis in the guinea-pig isolated trachea. Life Sci.2006; 79(1): 98-104.

OPEN ACCESS

Journal + Issues

Search