Effects of Ingredients on Cigarette Smoke Composition and Biological Activity: A Literature Overview

T Paschke 1 , 2 , G Scherer 3  and WD Heller 1
  • 1 Verband der Cigarettenindustrie, Scientific Department, Berlin, Germany
  • 2 Present address: Japan Tobacco International, Geneva, Switzerland
  • 3 Analytisch Biologisches Forschungslabor GmbH, ABF, München, Germany

Abstract

This paper presents a literature review of published scientific studies of the effects of tobacco product ingredients and various experimental additives on cigarette smoke composition and its biological activity. The format of this work is that of an uncommented reference paper rather than a critical scientific review. Therefore, the mention of an ingredient in this survey does not imply that it is used by the tobacco industry or that it is covered by any existing national regulations. A broad range of scientific papers and patents on tobacco ingredients is included as well as studies on experimental ingredients. This review may provide public health officials as well as scientists in government agencies and in the tobacco industry with a helpful overview of published information on tobacco product ingredients, their transfer into mainstream cigarette smoke, pyrolysis products, and influence on the biological activity of mainstream cigarette smoke.

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  • 1) Action on smoking and health (ASH), Bates, C, M. Jarvis and G. Connolly: Tobacco additives. Cigarette engineering and nicotine addiction; http://www.ash. org.uk/papers/additives.html (1999).

  • 2) Adams, J.D., S.J. Lee and D. Hoffmann: Carcinoge-nic agents in cigarette smoke and the influence of nitrate on their formation; Carcinogenesis 5 (1984) 221–223.

  • 3) Aksu, S.: Einige organische Salze als Feuchthalte-mittel in Cigaretten; Beitr. Tabakforsch. 5 (1969) 18–19.

  • 4) Alvord, E.T. and S.Z. Cardon: The inhibition of for-mation of 3,4-benzpyrene in cigarette smoke; Brit. J. Cancer 10 (1956) 498–503.

  • 5) An, H., Y. Shi, L. Huang, G. Feng and J. An: Manu-facture of composite material for decreasing tar and filtering poison of cigarette; Chinese Patent No. A24B15/28 (May 1996).

  • 6) Armbrust, B.F.and V.G. Carithers:Tobacco composition; U.S. Patent No. 3,410,276 (Nov. 1968).

  • 7) Van Auken, T.V., H.J. Grubbs and W.R. Johnson, Jr.: Smoking tobacco compositions; U.S. Patent No. 4,177,339 (Dec. 1979).

  • 8) Badgett, C.E. and J.S. Osmalov: Flavor-releasing smoking article and method of making the same; U.S. Patent No. 3,603,319 (Sept. 1971).

  • 9) Baldry, P.J., C.F. Cullis, D. Goring and M.M. Hirschler: The combustion of cigarette paper; Fire and Materials 12 (1988) 25–33.

  • 10) BAT– British-American Tobacco Co. Ltd.: Flavou-ring tobacco; Research Disclosure 16836 (Apr. 1978) p. 8.

  • 11) Bavley, A. and E.W. Robb: Rauchwaren und Ver-fahren, Rauchwaren Aroma zu verleihen; German Patent No. 1517302 (Sept. 1969).

  • 12) Bell, J.H., A.O. Saunders and A.W. Spears: The con-tribution of tobacco constituents to phenol yield of cigarettes; Tob. Sci. 10 (1966)138–142.

  • 13) Benner, J.F., H.R. Burton and D. Burdick: Temperature-yield profiles of tobacco and tobacco constitu-ents I: Borate-treated and untreated tobacco; Beitr. Tabakforsch. 5 (1969a) 74–79.

  • 14) Benner, J.F., H.R. Burton and D. Burdick: Temperature-yield profiles of tobacco and tobacco constitu-ents: II. Yields of phenol and cresols from untreated and borate-treated cellulose and lignin; Beitr. Tabak-forsch. 5 (1969b) 134–139.

  • 15) Bentley, H.R. and J.G. Burgan: Polynuclear hydro-carbons in tobacco and tobacco smoke. Part III. The inhibition of the formation of 3,4-benzopyrene in cigarette smoke; Analyst 85 (1960) 727–730.

  • 16) Biggs, P.J., R.T. Gilbert, K.G. McAdam and B. Na-tarajan: Smoking article and smoking material there-for; International Patent No. PCT/GB98/01586 (Dec. 1998).

  • 17) Bilimoria, M.H. and M.A. Nisbet: The reducing pro-perty of tobacco smoke: 1. Modified flue-cured tobacco and other smoking products; Beitr. Tabak-forsch. 8 (1975) 186–192.

  • 18) Bock, F.G., I. Michelson, I.D.J. Bross and R.L. Prio-re: Carcinogenic activity of smoke condensate from cigarettes with ammonium sulfamate-treated paper; Cancer 33 (1974) 1010–1016.

  • 19) Bombick, B.R., J.T. Avalos and K.P. Putnam: Com-parative studies on the genotoxic and cytotoxic po-tential of mainstream smoke condensate from menthol and non-menthol cigarettes which burn or prima-rily heat tobacco; 55th Tobacco Science Research Conference, Program Booklet and Abstracts, Vol. 55, Paper No. 8, 2001, p. 25.

  • 20) Briskin, T.S.: Smokable material and method for preparing same; U.S. Patent No. 4,133,317 (Jan. 1979).

  • 21) Brozinski, M., U. Dölberg and G. Lipp: Unter-suchungen über die Verteilung des Menthols auf Tabak, Filter und Rauch von Mentholcigaretten; Beitr. Tabakforsch. 6 (1972) 124–130.

  • 22) Brunnemann, K.D. and L. Posset: Routine high-per-formance liquid chromatographic method for asses-sing sorbate in tobacco; J. Chromatography 202 (1980) 494–499.

  • 23) Bryant Jr., H.G., V. Norman and T.B. Williams: Tobacco composition; U.S. Patent No. 4,177,822 (Dec. 1979).

  • 24) Burdick, D., J.F. Benner and H.R. Burton: Thermal decomposition of tobacco IV. Apparent correlations between thermogravimetric data and certain cons-tituents in smoke from chemically-treated tobaccos; Tob. Sci. 13 (1969) 138–141.

  • 25) Burton, H.R.: Thermal analyses of chemically-trea-ted tobacco; Proc. Tob. Health Workshop (1969) 33–37.

  • 26) Burton, H.R. and J.F. Benner: Investigations on the effect of chemical modifiers on tobacco and tobacco smoke; Proceedings of the University of Kentucky, Tobacco and Health Workshop Conference, Lexing-ton, 1972, p. 341–363.

  • 27) Candeli, A., A.J. Lindsey and K. Persaud: Carta di sigarette al sulfammato di ammonio e idrocarburi cancerigeni; Boll. Soc. Ital. Biol. Sper. 36 (1960) 452–454.

  • 28) Carmella, S.G., S.S. Hecht, T.C. Tso and D. Hoffmann: Roles of tobacco cellulose, sugars, and chloro-genic acid as precursors to catechol in cigarette smoke; J. Agric. Food. Chem. 32 (1984) 267–273.

  • 29) Carmines, E.L.: Evaluation of the potential effects of ingredients added to cigarettes. Part 1: Cigarette design, testing approach, and review of results; Food Chem. Toxicol. 40 (2002) 77–91.

  • 30) Carugno, N., S. Rossi and G. Lionetti: Gas-chroma-tographic determination of the trimethylsilyl deri-vatives of polyhydric alcohol humectants in tobacco and in tobacco smoke; Beitr. Tabakforsch. 6 (1971) 79–83.

  • 31) Chakraborty, B.B., K.D. Kilburn and R.E. Thornton: Reduction in the concentration of aromatic polycy-clic hydrocarbons in cigarette smoke; Chemistry and Industry (1971) p. 672.

  • 32) Chan, G.W., Y. Houminer, H.J. Grubbs, K.F. Podra-za and E.B. Sanders: Smoking compositions contai-ning a vanillin-release additive; European Patent No. EP 0 510 817 A1 (Oct. 1992).

  • 33) Cheng, A.L.S.: Sterol content in cigarette tobacco and smoke; Beitr. Tabakforsch. 7 (1973) 14–17.

  • 34) Chung H.L. and J.C. Aldridge: Thermal study of licorice by online thermogravimetry/gas chromato-graphy/mass spectrometry; 53rd Tobacco Science Research Conference Montréal, Canada, Program Booklet and Abstracts, Vol. 53, Poster No. 7, 1999, p. 23.

  • 35) Collins, P.F., H.G. Bryant, Jr., and J.O. Pullman: Tobacco composition including palladium; U.S. Patent No. 4,257,430 (March 1981).

  • 36) Cook, C.J., J.H. Lauterbach, W.T. Pannell, B.F. Pri-ce and W.M. Bowser: Transfer rate studies on ciga-rettes of various designs; 53rd Tobacco Science Research Conference Montréal, Canada, Program Booklet and Abstracts, Vol. 53, Paper No. 90, 1999.

  • 37) Cox, R.H., H.J. Grubbs and S.A. Haut: Smoking compositions containing a glycosylamine flavorant additive; U.S. Patent No. 4,638,816 (Jan. 1987).

  • 38) Crosthwaite, L., S.J. Sheen and H.R. Burton: Alkyla-ting activity in the extract and pyrolyzate of tobacco leaves varying in genotype and chemical treatment; Tob. Sci. 23 (1979) 35-37.

  • 39) Cullis, C.F., Hirschler, M.M., Townsend, R.P. and V. Visanuvimol: The combustion of cellulose under conditions of rapid heating; Combustion Flame 49 (1983a) 249-254.

  • 40) Cullis, C.F., Hirschler, M.M., Townsend, R.P. and V. Visanuvimol: The pyrolysis of cellulose under conditions of rapid heating; Combusition Flame 49 (1983b) 235-248.

  • 41) Curran, J.G.: Delivery of menthol from cigarettes containing either a mentholated filter or mentholated tobacco; Tob. Sci. 16 (1972) 40-42.

  • 42) Curran, J.G.: Effect of certain liquid filter additives on menthol delivery; Tob. Sci. 19 (1975) 69-70.

  • 43) Cuzin, J.-L., M. Hubert-Habart, B. Muel, R. Royer and R. Latarjet: La production du benzo-3,4 pyrène dans des cigarettes à papier imprégné de sulfamate d'ammonium; Bulletin de la Société Chimique de France 5 (1960) p. 982.

  • 44) Dalhamn, T.: The anticiliostatic effect of cigarettes treated with oxolamine citrate; Amer. Rev. Resp. Dis. 99 (1969) 447-448.

  • 45) Dalhamn, T. and R. Rylander: Reduction of cigarette smoke ciliotoxicity by certain tobacco additives; Amer. Rev. Resp. Dis. 103 (1971) 855-857.

  • 46) Detert, E.-R. and W. Ruchholz: Envelope for tobacco goods; U.S. Patent No. 3,826,268 (July 1974).

  • 47) Doihara, T., U. Kobashi, S. Sugawara, and Y. Kabu-raki: Studies on flavoring effect (IV). Pyrolysis of polyhydric alcohols; Scientific Papers of the Central Research Institute Japan Monopoly Corporation, 106 (1964) 129-135.

  • 48) Dontenwill, W., H.-J. Chevalier, H.-P. Harke, H.-J. Klimisch, U. Lafrenz und G. Reckzeh: Experimentel-le Untersuchungen über die tumorerzeugende Wir-kung von Zigarettenrauch-Kondensaten an der Mäu-sehaut. IV. Einzelvergleiche von Kondensaten aus verschiedenen Tabakfolien, Einfluß eines Zusatzes von NaNO3 zum Tabak oder zu Tabakfolien, Wir-kung flüchtiger Bestandteile des Rauches, Einfluß einer Initialbehandlung mit Dimethylbenzanthracen; Z. Krebsforsch. 78 (1972) 236-264.

  • 49) Dontenwill, W.: Search for a less hazardous cigarette. Excerpta Medica International Congress Series 3 (1974) 131-137.

  • 50) Dontenwill, W., H.-J. Chevalier, H.-P. Harke, H.-J. Klimisch, G. Reckzeh, B. Fleischmann and W. Keller: Experimentelle Untersuchungen über die tumor-erzeugende Wirkung von Zigarettenrauch-Kondensa-ten an der Mäusehaut. V. Mitteilung: Einzelverglei-che von Kondensaten verschiedener modifizierter Zigaretten; Z. Krebsforsch. 85 (1976) 141–153.

  • 51) Van Duuren, B.L., A. Sivak, L. Langseth, B.M. Goldschmidt and A. Segal: Initiators and promoters in tobacco carcinogenesis; National Cancer Institute Monograph 28 (1968) 173–180.

  • 52) Eicher, T. and F. Müller: Rauchbare Produkte; German Patent No. 2729759 (May 1985).

  • 53) Ellis, C., R. Cox, C. Callicutt, S. Laffoon, K. Podra-za, J. Seeman, R. Kinser, D. Farthing and F. Hsu: The effect of ingredients added to tobacco in a com-mercial Marlboro Lights cigarette on FTC nicotine yield, “smoke pH”, and Cambridge filter trapping efficiency; CORESTA, Meeting of the smoke and technology study groups, 5–9th September 1999, Innsbruck, Austria.

  • 54) EU-Directive 2001/37/EC: On the approximation of the laws, regulations and administrative provisions of the Member States concerning the manufacture, pre-sentation and sale of tobacco products; Official Journal L 194 (18/07/2001) 26–35.

  • 55) Frattini, C., C. Bicchi, C. Barettini, and G.M. Nano: Volatile flavor components of licorice; J. Agric. Food Chem. 25 (1977) 1238–1241.

  • 56) Gager Jr., F.L., J.W. Nedlock and W.J. Martin: Tobacco additives and cigarette smoke. Part I. Transfer of D-glucose, sucrose, and their degradation products to the smoke; Carbohydrate Res. 17 (1971a) 327–333.

  • 57) Gager Jr., F.L., J.W. Nedlock and W.J. Martin: Tobacco additives and cigarette smoke. Part II. Organic, gas-phase products from D-glucose and sucrose; Car-bohydrate Res. 17 (1971b) 335–339.

  • 58) Garcia Roche, M.O., A. Cabrera, A. Becquer, C. Duverger, M. Cuervo and J. Guardiola: Health risk due to the use of nitrate in the manufacture of Cuban golden cigarettes; Rev. Cubana Hig. Epidemiol. 24 (1986) 487–492.

  • 59) Gargus, J.L., J.B. Sullivan, R.T. Habermann, J. Copeland and J. Everly: Mouse dermal study of smoke condensate from “Chemosol”-treated cigaret-tes; Tox. Appl. Pharm. 33 (1975) 568–574.

  • 60) Gaworski, C.L., M.M. Dozier, J.M. Gerhart, N. Ra-jendran, L.H. Brennecke, C. Aranyi and J.D. Heck: 13-week inhalation toxicity study of menthol cigaret-te smoke; Fd. Chem. Toxic. 35 (1997) 683 – 692.

  • 61) Gaworski, C.L., M.M. Dozier, J.D. Heck, J.M. Ger-hart, N. Rajendran, R.M. David, L.H. Brennecke and R. Morrissey: Toxicologic evaluation of flavor in-gredients added to cigarette tobacco: 13-week inhalation exposure in rats; Inhal. Toxicol. 10 (1998) 357–381.

  • 62) Gaworski, C.L., J.D. Heck, M.B. Bennett and M.L. Wenk: Toxicologic evaluation of flavor ingredients added to cigarette tobacco: skin painting bioassay of cigarette smoke condensate in SENCAR mice; Toxi-cology 139 (1999a) 1–17.

  • 63) Gaworski, C.L., J.D. Heck and N. Rajendran: Toxicologic evaluation of glycerine and propylene glycol added to cigarette tobacco: 13-week inhalation stu-dies in Fisher-344 rats; 53rd Tobacco Science Research Conference Montréal, Canada, Program Booklet and Abstracts, Vol. 53, Poster No. 5, 1999b, p. 21.

  • 64) Gilbert, J.A.S. and AJ. Lindsey: The thermal decom-position of some tobacco constituents, Br. J. Cancer, 11 (1957) 398-402.

  • 65) Glantz, S.A., J. Slade, L.A., Bero, P. Hanauer and D.E. Barnes: The Cigarette Papers; University of California Press, Berkeley and Los Angeles, California, 1996.

  • 66) Grant, S.J.: Catalytic and non-catalytic additives for the removal of carbon monoxide from cigarette smoke; 34th Tobacco Chemists Research Conference, Paper No. 54, 1980, p. 28.

  • 67) Green, J.D., J. Chalmers and P.J. Kinnard: The transfer of tobacco additives to cigarette smoke: Examination of the possible contribution of pyrolysis pro-ducts to mainstream smoke composition; Beitr. Tabakforsch. Int. 14 (1989) 283-288.

  • 68) Grubbs, H.J., T.V. Van Auken and W.R. Johnson Jr.: OC-Substituted vinyl menthyl carbonates; U.S. Patent No. 4,127,601 (Nov. 1978).

  • 69) Grubbs H.J. and Y. Houminer: Flavour-release com-positions; European Patent No. 0 064 326 A1 (March 1982).

  • 70) Gutcho, S.: Tobacco flavoring substances and methods; Noyes Data Corporation, Noyes Building, Park Ridge, New Jersey, USA, 1972, p. 1-161.

  • 71) Halter, H.M. and T.I. Ito: Reconstituted tobacco -smoking and health possibilities; J. Natl. Cancer Inst. 48 (1972) 1869-1883.

  • 72) Herron, J.: Tobacco product containing side stream smoke flavorant; European Patent No. WO 88/09133 (Dec. 1988).

  • 73) Higman, E.B., Schmeltz, I. and W.S. Schlotzhauer: Products from the thermal degradation of some na-turally occurring materials, J. Agric. Food Chem., 18 (1970) 636-639.

  • 74) Higman, H.C., E.B. Higman and O.T. Chortyk: Pyrolysis of selected tobacco flavoring additives; Tob. Sci. 18 (1974) 136-138.

  • 75) Hoffmann, D. and E.L. Wynder: The reduction of the tumorigenicity of cigarette smoke condensate by addition of sodium nitrate to tobacco; Cancer Res. 27 (1967) 172-174.

  • 76) Hoffmann, D. and E.L. Wynder: Selective reduction of the tumorigenicity of tobacco smoke. Experimen-tal approaches; in: Toward a less harmful cigarette, edited by E.L. Wynder and D. Hoffmann, Natl. Cancer Inst. Monograph 28 (1968) 151-172.

  • 77) Hoffmann, D. and E.L. Wynder: Selective reduction of tumorigenicity of tobacco smoke. II. Experimental approaches; J. Natl. Cancer Inst. 48 (1972) 1855-1868.

  • 78) Ishiguro, S., T. Ohsumi, S. Matsushima and S. Suga-wara: A rapid method for the determination of poly-ols in cigarettes and leaf tobacco; Kenkyo Hokoku -Nippon Senbai Kosha Chuo Kenkyusho 121 (1979) 7-11.

  • 79) Jenkins Jr., R.W., R.H. Newman, R.D. Carpenter and T.S. Osdene: Cigarette smoke formation studies: I. Distribution and mainstream products from added 14C-dotriacontane-16, 17; Beitr. Tabakforsch. 5 (1970a) 295–298.

  • 80) Jenkins Jr., R.W., R.H. Newman and M.K. Chavis: Cigarette smoke formation studies: II. Smoke dis-tribution and mainstream pyrolytic composition of added 14C-menthol (U); Beitr. Tabakforsch. 5 (1970b) 299–301.

  • 81) Jenkins Jr., R.W., R.H. Newman, M.D. Edmonds and T.S. Osdene: Cigarette smoke formation studies: III. The contribution of dotriacontane to the benzo[a]py-rene content of smoke; Beitr. Tabakforsch. 7 (1973) 154–157.

  • 82) Jenkins Jr., R.W., M.K. Chavis, R.T. Bass and T.S. Osdene: Cigarette smoke formation studies: VI. The carbon contribution to total smoke from each indivi-dual component in the 1R1-type cigarette; Beitr. Tabakforsch. Int. 10 (1980) 145–148.

  • 83) Jing, Y. and K. Xian: The effects of different levels of filter ventilation on the deliveries of flavor con-stituents in mainstream smoke; CORESTA, Meeting of the smoke and technology study groups, 5–9th September 1999, Innsbruck, Austria.

  • 84) Jodl, R.: Über den Einfluß der Glimmsalze des Ciga-rettenpapiers auf die Abrauchergebnisse von Ciga-retten; Beitr. Tabakforsch. 5 (1969) 22–24.

  • 85) Johnson, W.R., R.W. Hale, S.C. Clough and P.H. Chen: Chemistry of the conversion of nitrate nitro-gen to smoke products; Nature 243 (1973) 223–225.

  • 86) Jones, R., P. Bolduc and L. Reid: Protection of rat bronchial epithelium against tobacco smoke; Brit. Med. J. 2 (1972) 142–144.

  • 87) Jones, R., P. Bolduc and L. Reid: Goblet cell glyco-protein and tracheal gland hypertrophy in rat airways: The effect of tobacco smoke with or without the anti-inflammatory agent phenylmethyloxadiazo-le; Br. J. Exp. Path. 54 (1973) 229–239.

  • 88) Kaburaki, Y., H. Shigematsu, Y. Mikami and H. Ku-sakabe: Studies on the composition of tobacco smoke (XI). Relations between vapor phase components of smoke and constituents of tobacco; Kenkyo Hokoku – Nippon Sembai Kosha Chuo Kenkyusho 111 (1969) 143–149.

  • 89) Kagan, M.R., J.A. Cunningham and D. Hoffmann: Propylene glycol: A precursor of propylene oxide in cigarette smoke; 53rd Tobacco Science Research Conference Montréal, Canada, Program Booklet and Abstracts, Vol. 53, Paper No. 41, 1999, p. 42.

  • 90) Kallianos, A.G., R.E. Means and J.D. Mold: Effect of nitrates in tobacco on the catechol yield in ciga-rette smoke; Tob. Sci. 12 (1968) 125–129.

  • 91) Kato, K.: Pyrolysis of cellulose, Part III. Comparati-ve studies of the volatile compounds from pyroly-sates of cellulose and its related compounds; Agric. Biol. Chem. 31 (1967) 657–663.

  • 92) Kato, K. and Y. Shibayama: The thermal decomposition products of vanillin and their transfer into ciga-rette smoke; Scientific Papers of the Central Research Institute Japan Monopoly Corporation 104 (1962) 115–121.

  • 93) Keritsis, G.D.: Tobacco treatment; European Patent No. 0 034 922 A1 (Sept. 1981).

  • 94) Kier, L.D., E. Yamasaki and B.N. Ames: Detection of mutagenic activity in cigarette smoke condensate; Proc. Nat. Acad. Sci. USA 71 (1974) 4159-4163.

  • 95) Klimisch, H.J.: Vergleichende chemisch-analytische Untersuchungen an Kondensaten modifizierter Ciga-retten. Diskussion einer Korrelation zur biologischen Wirksamkeit; Zeitschrift für Lebensmittel-Untersu-chung und -Forsch. 150 (1972) 93-99.

  • 96) Kobashi, U., T. Doihara, S. Sugawara and Y. Kabu-raki: Changes in chemical composition of smoke from cigarettes imparted with several polyols; Scientific Papers of the Central Research Institute Japan Monopoly Corporation 107 (1965) 319-323.

  • 97) Komatsu, H.: Reagent for removing harmful matter from cigarette; Japanese Patent No. JP 9238667 (Sept. 1997).

  • 98) Kossack, C: Verfahren zum Herabsetzen von beim Rauchen von Tabak im Verbrennungsbereich frei werdenden Schadstoffen; German Patent No. DE 3534504A1 (April 1987).

  • 99) Kratchanova, M., A. Stoilova, I. Panchev and A. Richnev: Characteristics and application of pectin extracts in cigarette production; Food Hydrocolloids 9 (1995) 97-102.

  • 100) Kröller, E.: Ergebnisse von Schwelversuchen an Farbstoffen zur Farbmattierung von Tabakwaren. 2. Mitteilung (Kreuzbeerenextrakt); Bundesgesundhbl. 20 (1963a) 317-318.

  • 101) Kröller, E.: Ergebnisse von Schwelversuchen an Farbstoffen zur Farbmattierung von Tabakwaren. 3. Mitteilung (Blauholzextrakt); Bundesgesundhbl. 21 (1963b) 332-335.

  • 102) Kröller, E.: Ergebnisse von Schwelversuchen an Farbstoffen zur Farbmattierung von Tabakwaren. 4. Mitteilung (Huminsäure); Bundesgesundhbl. 22 (1963c) 348-349.

  • 103) Kröller, E.: Ergebnisse von Schwelversuchen an Farbstoffen zur Farbmattierung von Tabakwaren; Bundesgesundhbl. 6 (1963d) 38-40.

  • 104) Kröller, E.: Ein Beitrag zur Beurteilung von Tabak-zusatzstoffen auf Grund ihrer Pyrolyseprodukte. 1. Cellulose und ihre Derivate; Bundesgesundhbl. 24 (1964a) 375-378.

  • 105) Kröller, E.: Ergebnisse von Schwelversuchen an Zu-satzstoffen zu Tabakwaren. 1. Mitteilung (Glykole); Deutsche Lebensmittel-Rundschau 60 (1964b) 235-239.

  • 106) Kröller, E.: Ergebnisse von Schwelversuchen an Zu-satzstoffen zu Tabakwaren. 2. Mitteilung (Polyglykole, Glycerin); Deutsche Lebensmittel-Rundschau 60 (1965a) 16-17.

  • 107) Kröller, E.: Ergebnisse von Schwelversuchen an Zu-satzstoffen zu Tabakwaren. 3. Mitteilung (Pflanzli-che Schleim- und Gummiarten); Deutsche Lebensmittel-Rundschau 61 (1965b) 150-155.

  • 108) Kröller, E.: Ein Beitrag zur Beurteilung von Tabak-zusatzstoffen auf Grund ihrer Pyrolyseprodukte. 2. Stärke und ihre Derivate; Bundesgesundhbl. 9 (1966a) 106-107.

  • 109) Kröller, E.: Ein Beitrag zur Beurteilung von Tabak-zusatzstoffen auf Grund ihrer Pyrolyseprodukte. 3. Weißbrand- und Flottbrandmittel; Bundesgesundhbl. 22 (1966 b) 333–334.

  • 110) Kröller, E.: Ergebnisse von Schwelversuchen an Farbstoffen zur Farbmattierung von Tabakwaren. 5. Mitteilung (Gelbholzextrakt); Bundesgesundhbl. 12 (1966 c) 173–174.

  • 111) Kröller, E.: Ergebnisse von Schwelversuchen an Zu-satzstoffen zu Tabakwaren. 4. Mitteilung; Deutsche Lebensmittel-Rundschau 62 (1966 d) 208–210.

  • 112) Kröller, E.: Ein Beitrag zur Beurteilung von Tabak-zusatzstoffen auf Grund ihrer Pyrolyseprodukte. 4. Aromastoffe; Bundesgesundhbl. 18 (1967) 277–279.

  • 113) Kröller, E.: Ergebnisse von Schwelversuchen an Zu-satzstoffen zu Tabakwaren. 5. Mitteilung; Deutsche Lebensmittel-Rundschau 64 (1968) 111–113.

  • 114) Kröller, E.: Untersuchungen zur Bestimmung des aus dem Tabak unzersetzt in den Rauch übergehenden Thiabendazols; Deutsche Lebensmittel-Rundschau 65 (1969) 85–86.

  • 115) Kröller, E.: Ein Beitrag zur Beurteilung von Tabak-zusatzstoffen auf Grund ihrer Pyrolyseprodukte. 5. Mitteilung; Bundesgesundhbl. 23 (1970) 321–323.

  • 116) Lakritz, L., R.L. Stedman and E.D. Strange: Com-position studies on tobacco XXXIX: Changes in smoke composition and filtration by artificial alteration of smoke pH: Formic and acetic acids and vola-tile phenols; Beitr. Tabakforsch. 5 (1969) 104–108.

  • 117) Lakritz, L., E.D. Strange, D.G. Bailey and R.L. Sted-man: Composition studies on tobacco: XLV. Use of cigarette additives to alter the composition and redu-cing properties of cigarette smoke; Beitr. Tabak-forsch. 6 (1972) 120–123.

  • 118) Laurene, A.H., R.H. Cundiff and G.H. Greene: De-termination of glycerol and propylene glycol in ciga-rette smoke; Tob. Sci. 9 (1965) 1–4.

  • 119) Leffingwell, J.C., H.J. Young, E. Bernasek: Tobacco flavoring for smoking products; R.J. Reynolds Tobacco Company, Winston-Salem 1972.

  • 120) Lindsey, A.J., K. Persaud and A. Candeli: Reduction of benzpyrene in tobacco smoke; Brit. Med. J. 2 (1959) 821.

  • 121) Lyerly, L.A.: Direct vapor chromatographic determi-nation of menthol, propylene glycol, nicotine and triacetin in cigarette smoke; Tob. Sci. 11 (1967) 49–51.

  • 122) Mariner, D.C., A.K. Armitage, M. Dixon, T. Higen-botham and N.M. Sinclair: The effect of inhalation volume and blend additives on nicotine retention and uptake; 2000 CORESTA Congress, Lisbon, Portugal, 15–19 October 2000, Information Bulletin, Abstract No. ST 24, p. 169.

  • 123) Marmor, R.S. and H.J. Minnemeyer: Material ba-lance studies on cigarettes containing 3-phenyl-5-methyl-1,2,4-oxadiazole; Beitr. Tabakforsch. 8 (1975) 199–203.

  • 124) Mathis, D.E.: Migration and delivery of filter flavors; Beitr. Tabakforsch. Int. 12 (1983) 1–8.

  • 125) Matsushita, H. and M. Shinozaki: Flavourant com-position for tobacco, method for its production and tobacco product containing said composition; Euro-pean Patent No. EP 0 014 105 A2 (Aug. 1980).

  • 126) McAdam, K.G.: Smokable filler material for smoking articles; International Patent No. PCT/GB97/00589 (March 1997).

  • 127) McCoy, E.C. and H.S. Rosenkranz: Cigarette smoking may yield nitroarenes; Cancer Letters 15 (1982) 9–13.

  • 128) Meier, W.M. and K. Siegmann: Significant reduction of carcinogenic compounds in tobacco smoke by the use of zeolite catalysts; Microporous and Mesopo-rous Materials 33 (1999) 307–310.

  • 129) Miano, R.R. and C.H. Keith; Smoking materials; U.S. Patent No. 3,931,824 (Jan. 1976).

  • 130) Michelson, I. and G. Rathkamp: Composition of ci-garette smoke: Effects of ammonium sulfamate in cigarette paper; Beitr. Tabakforsch. 7 (1974) 212–216.

  • 131) Miranda, E.J.F., A.A.S. Rodrigues, M.G.F. dos Santos and M.R. Luzia: Method to study the flavor transfer to cigarette smoke; 53rd Tobacco Science Research Conference Montréal, Canada, Program Booklet and Abstracts, Vol. 53, Paper No. 57, 1999, p. 51.

  • 132) Misra, M., D.J. Heck and C.L. Gaworski: Toxicolo-gic evaluation of diammonium phosphate added to cigarette tobacco and reconstituted leaf: 13-week smoke inhalation studies in rats; 55th Tobacco Science Research Conference, Program Booklet and Abstracts, Vol. 55, Paper No. 18, 2001, p. 30.

  • 133) Mitchell, B.C., E.P. Barbee and R.M. Irby Jr.: The chromatographic determination of menthol in ciga-rettes and cigarette smoke; Tob. Sci. 7 (1963) 64–66.

  • 134) Morie, G.P. and C.H. Sloan: Determination of N-nitrosodimethylamine in the smoke of high-nitrate tobacco cigarettes; Beitr. Tabakforsch. 7 (1973) 61–66.

  • 135) Müller, L. and W. Röper: Commentary. It ain't ne-cessarily so; Beitr. Tabakforsch. Int. 19 (2000) 51–54.

  • 136) NCI, National Cancer Institute, Smoking and Health Program: Toward less hazardous cigarettes: Report No. 1. The first set of experimental cigarettes; DHEW Publication No. (NIH) 76–905 (1976).

  • 137) NCI, National Cancer Institute, Smoking and Health Program: Toward less hazardous cigarettes: Report No. 3. The third set of experimental cigarettes; DHEW Publication No. (NIH) 77-12380 (1977).

  • 138) NCI, National Cancer Institute, Smoking and Health Program: Toward less hazardous cigarettes: Report No. 4. The fourth set of experimental cigarettes; DHEW Publication (1980).

  • 139) Nichols, W., R. Newsome, R. Thesing and W. Houck: Matrix entrapment of flavorings for smoking articles; European Patent No. 0 223 454 A2 (May 1987).

  • 140) Norman, V. and H.G. Bryant, Jr.: Composition de Tabac; Belgian Patent No. 827431 (July 1975).

  • 141) Norman, V., H.G. Bryant Jr. and T.B. Williams: Smoking composition; U.S. Patent No. 3,720,214 (March 1973).

  • 142) Ogawa, S.: Modifier for smoke flavor and perfume of cigarette; Japanese Patent No. 10066557 (March 1998).

  • 143) Ohshiro, M.: Regulator for smoking flavor of tobacco; International Patent No. PCT/JP98/04210 (April 1999).

  • 145) Perfetti, T.A. and H.H. Gordin: Just noticeable diffe-rence studies of mentholated cigarette products; Tob. Sci. 29 (1985) 57-67.

  • 146) Pintaske, F.: Zusatzstoff für Rauchtabak; German Patent No. 2942544 (April 1981).

  • 147) Prouse, R.E., A.A. West, D.A. King and R. Poulson: Smoking materials; U.S. Patent No. 4,005,718 (Feb. 1977).

  • 148) Pyriki, C, W. Moldenhauer and T. Knappe: Zur Fra-ge der Behandlung des Zigarettenpapiers und des Tabaks zwecks Verminderung von polycyklischen Kohlenwasserstoffen in deren Rauch; Ber. Inst. Tabakforsch. Dresden 12 (1965) 37-55.

  • 149) Rakieten, N., M.L. Rakieten, D. Feldman and M.J. Boykin Jr.: Mammalian ciliated respiratory epitheli-um. Studies with particular reference to effects of menthol, nicotine, and smoke of mentholated and nonmentholated cigarettes; Arch. Otolaryngol. 56 (1952) 494-503.

  • 150) Rathkamp, G. and D. Hoffmann: Chemical studies on tobacco smoke, XIII. Inhibition of the pyrosyn-theses of several selective smoke constituents; Beitr. Tabakforsch. 5 (1970) 302-306.

  • 151) Reif, G.: Der Nachweis von Aethylenglykol im Ta-bakrauch mit P-Naphthol; Pharmazie 4 (1949) 110-113.

  • 152) Riehl, T.F., L.L. Shockley and M.L. Reynolds: Menthol distribution and transfer; Tob. Sci. 17 (1973) 10-11.

  • 153) Robb, E.W., J.J. Westbrook, III and A. Bavley: The use of non-volatile adducts in smoke flavor; Tob. Sci. 8 (1964) 3-7.

  • 154) Robb, E.W., W.R. Johnson, J.J. Westbrook, and R.B. Seligman: Model pyrolysis - The study of cellulose; Fourth International Tobacco Scientific Congress Athens-Greece, September 19-26, 1966, p. 1075-1085.

  • 155) Römer, E., F.J. Tewes, T.J. Meisgen, D.J. Veltel and E.L. Carmines: Evaluation of the potential effects of ingredients added to cigarettes. Part 3: In vitro geno-toxicity and cytotoxicity; Food Chem. Toxicol. 40 (2002) 105-111.

  • 156) Römer, E. and U. Hackenberg: Mouse skin bioassay of smoke condensates from cigarettes containing different levels of cocoa; Food Add. Cont. 7(1990) 563-569.

  • 157) Rustemeier, K., R. Stabbert, H.-J. Haussmann, E. Römer and E.L. Carmines: Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke; Food Chem. Toxicol. 40 (2002) 93-104.

  • 158) Rylander, R.: Lung clearance of particles and bacte-ria. Effects of cigarette smoke exposure; Arch. Environ. Health 23 (1971) 321-326.

  • 159) Rylander, R.: Alteration of certain pulmonary smoke exposure reactions by phenylmethyloxadiazole (PMO); Scand. J. Resp. Dis. 54 (1973) 223-230.

  • 160) Saint-Jalm, Y., G. Duval, T. Conte and I. Bonnichon: Mechanisms of transfer of ammonia in cigarette smoke from ammonium compounds in tobacco; 2000 CORESTA Congress, 2000 CORESTA Congress, Lisbon, Portugal, 15-19 October 2000, Information Bulletin, Abstract No. ST 9, p. 153.

  • 160) Sakagami, H.: The behavior of glycyrrhizic acid and glycyrrhetinic acid added to tobacco on smoking. Studies on the components of licorice root used for tobacco flavouring. Part III; Nippon Nogei Kagaku Kaishi 47 (1973) 623–626.

  • 161) Sakuma, H., S. Munakata and S. Sugawara: Volatile products of cellulose pyrolysis; Agric. Biol. Chem. 45 (1981) 443–451.

  • 162) Sato, S., T. Ohka, M. Nagao, K. Tsuji and T. Kosu-ge: Reduction in mutagenicity of cigarette smoke condensate by added sugars; Mut. Res. 60 (1979) 155–161.

  • 163) Schlotzhauer, W.S.: Fatty acids and phenols from pyrolysis of cocoa powder, a tobacco product fla-vorant; Tob. Sci. 22 (1978) 1–2.

  • 164) Schlotzhauer, W.S., I. Schmeltz and L.C. Hickey: Pyrolytic formation of phenols from some high mole-cular weight tobacco leaf constituents and related non-tobacco materials; Tob. Sci. 11 (1967) 31–34.

  • 165) Schlotzhauer, W.S., R.M. Martin, M.E. Snook and R.E. Williamson: Pyrolytic studies on the contribution of tobacco leaf constituents to the formation of smoke catechols; J. Agric. Food Chem. 30 (1982) 372–374.

  • 166) Schlotzhauer, W.S., R.F. Arrendale and O.T. Chor-tyk: The rapid pyrolytic characterization of tobacco leaf carbohydrate material; Beitr. Tabakforsch. Int. 13 (1985) 74–80.

  • 167) Schlotzhauer, W.S., R.F. Severson and R.M. Martin: The contribution of sucrose esters to tobacco smoke composition; Beitr. Tabakforsch. Int. 13 (1986) 229–238.

  • 168) Schmeltz, I. and W.S. Schlotzhauer: Benzo[a]pyre-ne, phenols and other products from pyrolysis of the cigarette additive, (d,l)-menthol; Nature 219 (1968) 371.

  • 169) Schmeltz, I., W.S. Schlotzhauer, and E.B. Higman: Characteristic products from pyrolysis of nitrogenous organic substances; Beitr. Tabakforsch. 6 (1972) 134–138.

  • 170) Schmeltz, I., A. Wenger, D. Hoffmann and T.C. Tso: Chemical studies on tobacco smoke. 53. Use of ra-dioactive tobacco isolates for studying the formation of smoke components; J. Agric. Food Chem. 26 (1978) 234–239.

  • 171) Settle, V.A., R.T. Walker, R.D. Stevens and M.A. Sudholt: A fast gas chromatography method for si-multaneous analysis of menthol, propylene glycol, and glycerol using a multicapillary column; 53rd Tobacco Science Research Conference Montréal, Canada, Program Booklet and Abstracts, Vol. 53, Paper No. 67, 1999.

  • 172) Shepherd, T.H. and F.E. Gould: Tobacco smoke fil-ters; U.S. Patent No. 3,470,883 (Aug. 1968).

  • 173) Sjöberg, A.M. and H. Pyysalo: Identification of food thickeners by monitoring of their pyrolytic products; J. Chromatogr. 319 (1985) 90–98.

  • 174) Sloan, C.H. and J.E. Kiefer: Determination of NO and NO2 in cigarette smoke from kinetic data; Tob. Sci. 13 (1969) 180–182.

  • 175) Smit, H.: Die Wirkung einiger Feuchthaltemittel auf die Eigenschaften eines röhrengetrockneten Tabaks; Beitr. Tabakforsch. 5 (1970) 231–238.

  • 176) Southwick E.W.: Smoking compositions containing a vanillin-release additive; U.S. Patent No. 5,144,965 (Sep. 1992).

  • 177) de Souza, J.E. and M. Scherbak: The effect of glyce-rol added to tobacco on the constituents of cigarette smoke; The Analyst 89 (1964) 735–739.

  • 178) Stedman, R.L., L. Lakritz and E.D. Strange: Com-position studies on tobacco XXXIII. Changes in smoke composition and filtration by artificial alteration of smoke pH: Pyridine and nicotine; Beitr. Ta-bakforsch. 5 (1969) 13–17.

  • 179) Stein, Y.S. and M.J. Antal Jr.: A study of the gas-phase pyrolysis of glycerol; J. Anal. Appl. Pyrolysis 4 (1983) 283–296.

  • 180) Stoilova, A., M. Kratchanova and C. Kratchanov: Comparative investigations of the influence of poly-valent alcohols and fruit extracts on the physicoche-mical properties of tobacco; Beitr. Tabakforsch. Int. 16 (1994) 1–9.

  • 181) Stotesbury, S., H. Digard, L. Willoughby and A. Couch: The pyrolysis of tobacco additives as a me-ans of predicting their behaviour in a burning cigaret-te; Beitr. Tabakforsch. Int. 18 (1999) 147–163.

  • 182) Stotesbury, S.J., L.J. Willoughby and A. Couch: Py-rolysis of cigarette ingredients labelled with stable isotopes; Beitr. Tabakforsch. Int. 19 (2000) 55–64.

  • 183) Tabakverordnung (Verordnung über Tabakerzeugnis-se) vom 20. Dezember 1977, p. 1–12; in: Meyer, A.H.: Lebensmittelrecht, Band II, Bundesgesetze und Verordnungen sowie EG-Recht über Lebensmittel, Tabakerzeugnisse, kosmetische Mittel und Bedarfs-gegenstände; Stand 30.06.2000.

  • 184) Terrell, J.H. and I. Schmeltz: Cigarettes: Chemical effects of sodium nitrate content; Science 160 (1968) 1456.

  • 185) Terrell, J.H. and I. Schmeltz: Alteration of cigarette smoke composition, 1. Influence of certain additives; Tob. Sci. 14 (1970) 78–81.

  • 186) Thornton, R.E. and S.R. Massey: Some effects of adding sugar to tobacco; Beitr. Tabakforsch. 8 (1975) 11–15.

  • 187) Thornton, R.E. and C. Valentine: Determination of the balance of carbon-14 activity added to cigarettes; Beitr. Tabakforsch. 4 (1968) 287–292.

  • 188) Tiggelbeck, D.D. and M. Manes: Mentholated ciga-rette filter; U.S. Patent No. 3,972,335 (Aug. 1976).

  • 189) Tomasik, P.: The thermal decomposition of carbo-hydrates. Part I. The decompositon of mono-, di-, and oligo-saccharides; Advances in Carbohydrate Chemistry and Biochemistry 47 (1989) 203–278.

  • 190) TR Staff Report: Safe - Cig flavorings not a risk says independent panel; Tobacco Reporter 121 (1994) 32-39.

  • 191) Tso, T.C.: Process for treating tobacco; U.S. Patent No. 3,863,645 (Feb. 1975).

  • 192) Vanscheeuwijck, P.M., A. Teredesai, P.M. Terpstra, J. Verbeeck, P. Kuhl, B. Gerstenberg, S. Gebel and E.L. Carmines: Evaluation of the potential effects of ingredients added to cigarettes. Part 4: Subchronic inhalation toxicity; Food Chem. Toxicol. 40 (2002) 113-131.

  • 193) Wakeham, H. and H. Silberman: Effect of cellulose on taste of cigaret smoke; Beitr. Tabakforsch. 3 (1966) 605-610.

  • 194) Wynder, E.L. and D. Hoffmann: Present status of laboratory studies on tobacco carcinogenesis; Acta Pathol. Microbiol. Scand. 52 (1961) 119-132.

  • 195) Wynder, E.L. and D. Hoffmann: Ein experimenteller Beitrag zur Tabakrauchkanzerogenese; Dtsch. Med. Wschr. 88 (1963) 623-628.

  • 196) Wynder, E.L. and D. Hoffmann: A study of tobacco carcinogenesis. X. Tumor promoting activity; Cancer 24 (1969) 289-301.

  • 197) Yang, H., J. Liu, K. Li, X. Yin, X. Tan and J. Wang: Synthesis of 3-oxo-0C-ionol ethyl carbonate and its conversion of megastigmatrienones in tobacco smoke; Beitr. Tabakforsch. Int. 19 (2001) 339-343.

  • 198) Yongkuan, C.and H. Wangyun: Pyrolysis of glycyr-rhizic acid and its sodium salts; Tob. Sci. 39 (1995) 49-54.

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