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Abstract

Introduction: Until recently, oxytocin was mainly associated with the pathophysiology of childbirth and sexual functions, but lately this hormone has become the object of interest to psychiatry and psychology due to the significant influence of oxytocin on human behavior in the field of social and emotional functioning. Current scientific research focuses on the participation of oxytocin in the pathogenesis and therapy of mental disorders.

Aim: The aim of the paper is to present, on the basis of available literature, the significance of oxytocin for various psychological functions, with particular emphasis on the influence of oxytocin on the course and clinical picture of schizophrenia.

Method: Available articles from the Medline / PubMed database were analyzed, which were searched using keywords: oxytocin, schizophrenia, therapeutic use of oxytocin, social cognition, positive symptoms, negative symptoms and time descriptors: 2013-2017. There are included articles published in Polish and English.

Results:The research results carried out so far suggest that oxytocin plays a significant role in modulating complex socio-emotional behaviors in schizophrenic patients. The existing research results also indicate a relationship between the dysregulation of the oxytocinergic system and the pathophysiology of schizophrenia. Many of the studies prove that there is a relationship between the level of oxytocin in the patients' blood plasma and the severity of the disease symptoms. Recent genetic studies indicate a possible relationship between polymorphism of oxytocin genesand polymorphism of oxytocin receptor genes and the risk of developing schizophrenia.

Conclusions: Contemporary research on the therapeutic potential of oxytocin and its influence on the functioning of schizophrenia patients seem to be very promising and may contribute to increasing the effectiveness of treatment of schizophrenia and possibly other mental disorders, which in turn will improve the quality of life of patients in cognitive, social and emotional functioning.

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  • 1. Sogolow S.R. An historical review of the use of oxytocin prior to delivery. ObstetGynecolSurv. 1966; 21(2):155–72

  • 2. Olff M. Frijling J. L. Kubzansky M. et al. The role of oxytocin in social bonding stress regulation and mental health: an update on the moderating effects of context and interindividual differences. Psychoneuroendocrinology 2013; 38(9) 1883-1894

  • 3. Tachibana M. et al. Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders. Journal of child and ado-lescent psychopharmacology 2013; 23.2: 123-127

  • 4. Jones R. E. Lopez K.H. Human reproductive biology. Academic Press 2013; 303.

  • 5. Burbach J.P. Young L.J. Russell J. Oxytocin: synthesis secretion and reproductive functions. In: Neill JD. editor. Knobil and Neill's Physiology of Reproduction. Elsevier; New York; 2006. p. 3055-3127.

  • 6. Dale H.H. On some physiological actions of ergot. J Physiol 1906; 34:163–206.

  • 7. Ross H.E. Young L.J. Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior Front Neuroendocrinol 2009; 30(4): 534–547

  • 8. Kirsch P. et al. Oxytocin modulates neural circuitry for social cognition and fear in humans. Journal of neuroscience 2005; 25.49: 11489-11493.

  • 9. Buchheim A. et al. Oxytocin enhances the experience of attachment security. Psychoneuroendocrinology 2009; 34.9: 1417-1422.

  • 10. Carter C. S. Porges S. W. The biochemistry of love: an oxytocin hypothesis. EMBO reports 2013; 14.1: 12-16.

  • 11. Labuschagne I. et al. Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology 2010; 35.12: 2403-2413.

  • 12. Kocoska-Maras L. et al. Cognitive function in association with sex hormones in postmenopausal women. Gynecological Endocrinology 2013; 29.1: 59-62.

  • 13. Bartz J.A. Hollander E. Oxytocin and experimental therapeutics in autism spectrum disorders. Progress in Brain Research. 2008; 170: 451–62.

  • 14. Gibson C.M. An investigation of the effects of oxytocin on social cognition and social functioning in schizophrenia. Diss. The University of North Carolina at Chapel Hill. 2012.

  • 15. McQuaid R. J. Making room for oxytocin in understanding depression. Neuroscience &Biobehavioral Reviews. 2014; 45: 305-322.

  • 16. Lawson E. A. Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa. The Journal of Clinical Endocrinology & Metabolism. 2012; 97(10): 1898-1908.

  • 17. Ganong W. Fizjologia. Warszawa: PZWL; 2007 s. 240.

  • 18. Konturek S. Wydzielanie wewnętrzne. W: Traczyk W. Trzebski A. Fizjologia człowieka z elementami fizjologii stosowanej i kli-nicznej. Wyd. III. Warszawa: PZWL; 2007 s. 343-345.

  • 19. Wójciak P. Remmlinger-Molenda A. Rybakowski J. The role of oxytocin and vasopressin in central nervous system activity and mental disorders. Psychiat. Pol. 2012; 46: 1043-1052.

  • 20. Wójciak P. Remlinger-Molenda A. Rybakowski J. Rola oksytocyny i wazopresyny w czynności ośrodkowego układu nerwowego i w zabu-rzeniach psychicznych. Psychiatr. Pol. 2012; 46 (6): 1044-1046.

  • 21. Carter C.S. Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinol. 1998; 23: 779–818.

  • 22. Bartz J. Zaki J. Ochsner K. et al. Effects of oxytocin on recollections of maternal care and closeness. Psychol. Cogn. Sc. 2010; 107 (50): 21371–21375.

  • 23. Netheron E. Schatte D. Potential for oxytocin use in children and adolescents with mental illness. Hum. Psychopharmacol. 2011; 26: 271-281.

  • 24. Bosh O. J. Sartor S. B. Singewald N. Neumann I. D. Extracellular amino acid levels in the paraventricular nucleus and the central amygdala in high and low anxiety dams rats during maternal aggression: regulation by oxytocin. Stress. 2007; 10: 261-270.

  • 25. Dębiec J. Peptides of love and fear; vasopressin and oxytocin modulate the integration of information in the amygdala. BioEssays 2005; 27: 869-873.

  • 26. Strauss G.P. Keller W.R. Koenig J.I. Gold J.M. Ossenfort K.L. Buchanan R.W. Plasma oxytocin levels predict olfactory identification and negative symptoms in individuals with schizoph-renia. Schizophrenia research 2015; 162.1: 57-61.

  • 27. Fetissov S.O. Hallman J. Nilsson I. Lefvert A.K. Oreland L. Hokfelt T. Aggressive behawior linked to corticotropin-reactive autoantibodies. Biol. Psychiatry. 2006; 60(8): 799-802.

  • 28. Uvnas-Moberg K. Oxytocin may mediate the beneficts of positive social interaction and emotions. Psychoneuroendocrinol. 1998; 23(8): 819-835.

  • 29. Strathearn L. Fonagy P. Amico J. Montague PR. Adult attachment predicts maternal brain and oxytocin response to infant cues. Neuropsychopharmacol. 2009; 34(13): 2655-2666.

  • 30. Bartels A. Zeki S. The neural correlates of maternal and romantic love. Neuroim. 2004; 21(3): 1155-1166.

  • 31. Sltzer LJ. Zieger TE. Pollak S. Social vocalizations can release oxytocin in humans. Proc. Biol. S.C. 2010; 277.1694: 2661-2666.

  • 32. Naber F. et al. Intranasal oxytocin increases fathers observed responsiveness during play with their children; a double-blind within-subject experiment. Psychoneuroendocrinol. 2010.35.10: 1583-1586.

  • 33. Zaka P. J. Kurzband R. Matznere W. T. Oxytocin is associated with humans trust worthivess. Horm. Behav. 2005; 48: 522-527

  • 34. Bartholomeusz C. F. Ganella E. P. Labuschagne I. Bousman C. Pantelis C. Effects of oxytocin and genetic variants on brain and behaviour: implications for treatment in schizophrenia. Schizophrenia Research 2015; 168(3) 614-627.

  • 35. Feifel D. Reza T. Oxytocin modulates psychotomimetic-induced deficits in sensorimotor gating. Psychopharmacology 1999; 141(1) 93-98.

  • 36. Caldwell H. K. Stephens S. L. Young W. S. Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice. Molecular psychiatry 2009;14(2) 190-196.

  • 37. Meziane H. et al. An early postnatal oxytocin treatment prevents social and learning deficits in adult mice deficient for Magel2 a gene involved in Prader-Willi syndrome and autism. Biological psychiatry 2015; 78(2) 85-94.

  • 38. Peñagarikano O. et al. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Science translational medicine 2015; 7(271) 271ra8-271ra8.

  • 39. Wiener D. Rybakowski J. Zaburzenia poznania społecznego w schizofrenii. Psychiatr Pol 2006; 40: 205-218.

  • 40. Gamer M. Does the amygdala mediate oxytocin effects on socially reinforced learning?. Journal of Neuroscience 2010; 30.28: 9347-9348.

  • 41. LeDoux J.E. Emotion circuits in the brain. Annu. Rev. Neurosci. 2000; 23 155–184.

  • 42. Yaniv D. Desmedt A. Jaffard R. Richter-Levin G. The amygdala and appraisal processes: stimulus and response complexity as an organizing factor. Brain Res. Rev. 2000; 44: 179–186.

  • 43. Shaw P. et al. The impact of early and late damage to the human amygdala on ‘theory of mind’ reasoning. Brain 2004; 127: 1535–1548.

  • 44. Anticevic A. et al. Amygdala recruitment in schizophrenia in response to aversive emotional material: a meta-analysis of neuroimaging studies. Schizophrenia bulletin 2010 38.3: 608-621.

  • 45. Van Snellenberg J.X. et al. Amygdala Recruitment in Schizoph-renia in Response to Aversive Emotional Material: A Meta-Analysis of Neuroimaging Studies. In: Biological Psychiatry. 360 Park Ave South New York Ny 10010-1710 Usa: Elsevier Science Inc 2011. P. 240s-240s

  • 46. Wright I.C. Rabe-Hesketh S. Woodruff P.W. et al. Meta analysis of regional brain volumes in schizophrenia. Am. J. Psychiatry 2000; 157: 16–25

  • 47. Rosenfeld A.J. Lieberman J.A. Jarskog L.F. Oxytocin dopamine and the amygdala: a neurofunctional model of social cognitive deficits in schizophrenia. Schizophr Bull. 2011; 37:1077–87.

  • 48. Holka-Pokorska J. Jarema M. Oksytocynowy model powstawania objawów psychotycznych a implikacje dla badań nad rolą systemu oksytocynergicznego w schizofrenii. Psychiatr. Pol 2014; 48.1: 19-33.

  • 49. Quintana D. S. et al. Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders. Frontiers in neuroendocrinology 2017; 45: 1-10.

  • 50. Rich M.E. Caldwell H. K. A role for oxytocin in the etiology and treatment of schizophrenia. Frontiers in endocrinology 2015; 6.

  • 51. Dey A. et al. Effects of oxytocin on neural response to facial emotion recognition in schizophrenia. In: Schizophrenia Bulletin. Great Clarendon St Oxford Ox2 6dp England: Oxford Univ Press 2017; p. S75-S76.

  • 52. Feldman R. et al. Oxytocin pathway genes: evolutionary ancient system impacting on human affiliation sociality and psychopa-thology. Biological Psychiatry 2016; 79.3: 174-184.

  • 53. Montag C. Brockmann E.B. Bayerl M. et al. Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: a case-control study. World J. Biol. Psychiatry 2013; 14(7): 500–508

  • 54. Souza R.P. Ismail P. Meltzer H.Y. Kennedy J.L. Variants in the oxytocin gene and risk for schizophrenia. Schizophr. Res. 2010; 121: 279-280.

  • 55. Souza R.P. et al. Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes. Int J Neuropsy-chopharmacol. 2010; 13:793–8.

  • 56. Goldman M. Marlow-O’Connor M. Torres I. Carter C.S. Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits. Schizophr Res. 2008; 98:247–55.

  • 57. Goldman M.B. Brain circuit dysfunction in a distinct subset of chronic psychotic patients. Schizophrenia Research 2014 157.1: 204-213.

  • 58. Rubin L.H et al. Peripheral oxytocin is associated with reduced symptom severity in schizophrenia. Schizophr Res. 2010; 124:13–21.

  • 59. Rubin L.H. et al. Sex-specific associations between peripheral oxytocin and emotion perception in schizophrenia. Schizophr Res. 2011; 130:266–70.

  • 60. Feifel D. Shilling P. D. MacDonald K. A review of oxytocin’s effects on the positive negative and cognitive domains of schi-zophrenia. Biological psychiatry 2016; 79(3) 222-233.

  • 61. Rubin L.H. et al. Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. Schizophrenia bulletin 2014; 40.6: 1374-1384.

  • 62. Rubin L.H Carter C.S Bishop J.R Pournajafi-Nazarloo H Harris M.S Hill S.K et al. Peripheral vasopressin but not oxytocin relates to severity of acute psychosis in women with acutely-ill untreated first-episode psychosis. Schizophr Res. 2013; 146(1–3):138–43.

  • 63. Sasayama D. Hattori K. Teraishi T. Hori H. Ota M. Yoshida S. et al. Negative correlation between cerebrospinal fluid oxytocin levels and negative symptoms of male patients with schizoph-renia. Schizophrenia research 2012 139.1: 201-206.

  • 64. Jobst A. Dehning S. Ruf S. Notz T. Buchheim A. Henning-Fast K. et al. Oxytocin and vasopressin levels are decreased in the plasma of male schizophrenia patients. ActaNeuropsychiatr. 2014; 26(6):347–55.

  • 65. Keri S. Kiss I. Kelemen O. Sharing secrets: oxytocin and trust in schizophrenia. SocNeurosci. 2009; 4(4):287–93. 795449706

  • 66. Haram M Tesli M Bettella F Djurovic S Andreassen OA Melle I. Association between Genetic Variation in the Oxytocin Receptor Gene and Emotional Withdrawal but not between Oxytocin Pathway Genes and Diagnosis in Psychotic Disorders. Front Hum Neurosci. 2015; 9:9

  • 67. American Psychiatric Association et al. Diagnostic and statistical manual of mental disorders (DSM-5). American Psychiatric Pub. 2013; s. 87-122.

  • 68. Bellack A.S. et al. Remediation of cognitive deficits in schizophrenia. The American journal of psychiatry 1990;147.12: 1650

  • 69. Taylor M. A.; Abrams R. Cognitive impairment patterns in schizophrenia and affective disorder. Journal of Neurology Neurosurgery& Psychiatry. 1987; 50.7: 895-899.

  • 70. Penn D.L. Addington J. Pinkham A. Zaburzenia poznania społecznego. W: Lieberman J. Stroup T.S. Perkins D.O. red. Schizo-frenia. Washington DC London UK: American Psychiatric Publishing Inc. 2006; s. 263–278.

  • 71. Fett A.K. et. al. The relationship between neurocognition and social cognition with functional outcome in schizophrenia: a metaanalysis. Neurosci. Biobehav. Rev. 2011; 35(3): 573–588.

  • 72. Wiener D. et al. Zaburzenia teorii umysłu oraz empatii w schizo-frenii i chorobie afektywnej dwubiegunowej. Neuropsychiatria i Neuropsychologia 2011; 6.2: 85-92.

  • 73. Evangeli M. Broks P. Face processing in schizophrenia: parallels with the effects of amygdala damage. Cognit. Neuropsychiatry 2000; 5: 81–104.

  • 74. Gur R.E. McGrath C. Chan R.M. iwsp. An fMRI study of facial emotion processing in patients with schizophrenia. Am. J. Psychiatry 2002; 159: 1992–1999.

  • 75. Haxby J. Hoffman E. Gobbini M. The distributed neural system for face perception. Trends Cognit. Sci. 2000; 4: 223–233.

  • 76. Hellewell J.S. Affect judgement and facial recognition memory in schizophrenia. Psychopathology 1994; 27: 255–261.

  • 77. Człapa K. Wysok D. Rybakowski F. Deficyty poznania społecznego w zaburzeniach ze spektrum autyzmu-porównanie ze schizofrenią. Neuropsychiatry & Neuropsychology 2016;11(1):12-20.

  • 78. Spychalska K. Kucharska-Pietura K. Kielan K. Neurobiologia społecznego poznania w schizofrenii. Psychiatria 2004;1.1: 9-15.

  • 79. Green M.F. Olivier B. Crawley J.N. Penn D.L. Silverstein S. Social cognition in schizophrenia: recommendations from the MATRICS new approaches conference. Schizophr. Bull. 2005; 31(4): 882-887.

  • 80. Frith C.D. Frith U. The neural basis of mentalizing. Neuron 2006; 50(4): 531–534.

  • 81. Górska D. Marszał M. Mentalizacja i teoria umysłu w organiza-cji osobowości borderline –r óżnice pomiędzy afektywnymi i poznawczymi aspektami poznania społecznego w patologii emocjonalnej. Psychiatria Polska 2014; 48(3).

  • 82. Tager-Flusberg H. Sullivan K. A componential view of theory of mind: evidence from Williams syndrome. Cognition 2000; 76.1: 59-90.

  • 83. Bora E. Yucel M. Pantelis C. Theory of mind impairment in schizoph-renia: meta-analysis. Schizophrenia research 2009; 109.1: 1-9.

  • 84. Gavilán J.M. García-Albea J.E. Theory of mind and language comprehension in schizophrenia: Poor mindreading affects figurative language comprehension beyond intelligence deficits. Journal of Neurolinguistics 2011; 24.1: 54-69.

  • 85. Strauss G.P Keller W.R. Koenig J.I. Sullivan S.K. Gold J.M. Buchanan R.W. Endogenous oxytocin levels are associated with the perception of emotion in dynamic body expressions in schi-zophrenia. Schizophr Res. 2015; 162(1–3):52–6.

  • 86. Averbeck et al. 2011. Averbeck B.B. Bobin T. Evans S. and Shergill S.S.: Emotion recognition and oxytocin in patients with schizophrenia. Psychol. Med. 2011; undefined: pp. 1-8

  • 87. Strauss G. P. Keller W. R. Koenig J. I. Gold J. M. Frost K. H. Buchanan R. W. Plasma oxytocin levels predict social cue recognition in individuals with schizophrenia. Schizophrenia Research 2015162(0) 47–51

  • 88. Walss-Bass C. Fernandes J. M. Roberts D. L. Service H. &Velligan D. Differential correlations between plasma oxytocin and social cognitive capacity and bias in schizophrenia. Schizophrenia research 2013; 147(2) 387-392.

  • 89. Davis M.C. Horan W.P. Nurmi E.L. Rizzo S. Li W. Sugar C.A et al. Associations between oxytocin receptor genotypes and social cognitive performance in individuals with schizophrenia. Schi-zophr Res. 2014; 159(2–3):353–7.

  • 90. Green M.F. Horan W.P. Lee J. Social cognition in schizophrenia. Nature Reviews Neuroscience 2015; 16(10) 620-631.

  • 91. Green M.F. Harvey P.D. Cognition in schizophrenia: Past present and future. Schizophrenia Research: Cognition 2014; 1(1) e1-e9

  • 92. Frost K Keller W Buchanan R Gold J Koenig J Ossenfort K et al. Plasma Oxytocin Levels are Associated with Impaired Social Cognition and Neurocognition in Schizophrenia. Archives of clinical neuropsychology: the official journal of the National Academy of Neuropsychologists 2014; 29(6):577–8.

  • 93. Michalopoulou P. G. Averbeck B. B. Kalpakidou A. K. Evans S. Bobin T. Kapur S. Shergill S. S. The effects of a single dose of oxytocin on working memory in schizophrenia. Schizophrenia research 2015; 162(1-3) 62.

  • 94. Feifel D. MacDonald K. Cobb P. Minassian A. Adjunctive intra-nasal oxytocin improves verbal memory in people with schizophrenia. Schizophrenia research 2012; 139(1) 207-210.

  • 95. Bujanow W. Is oxytocin an anti-schizophrenic hormone? Can. Psychiatr. Assoc. J. 1974; 19: 323.

  • 96. Bujanow W. Hormones in the treatment of psychoses. Br Med J. 1972; 4(5835):298.

  • 97. Fawtrel M Loh K Blake A Ridout D Hawdon J. Randomised double blind trial of oxytocin nasal spray in mothers expressing breast milk for preterm infants. Arch. Dis. Child Fetal Neuonatal. Ed. 2006; 91: F169–F174

  • 98. Sarnay Z Kovacs GL. Role of oxytocin in the neuroadaptation to drugs of abuse. Psychoneuroendocrinol. 1994; 19: 85–117.

  • 99. Domes G.; Heinrichs M.; Michel A.; Berger C.; Herpertz S.C. Oxytocin improves “mind-reading” in humans. Biol. Psychiatry 2007; 61: 731-733.

  • 100. Feifel D Macdonald K Nguyen A. Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients. Biol. Psychiatry 2010; 68 (7): 678–680.

  • 101. Sherry D. F. Neuroecology. Annu. Rev. Psychol. 2006; 57: 167-197.

  • 102. Kaba H. Neurobiology of mmmalian olfactory learning that occurs during sensitive periods. Curr. Zool. 2010; 56: 819-833.

  • 103. McDonald K. McDonald T.M.: The peptide that binds: a syste-matic review of oxytocin and its prosocial effects in humans. Harv. Rev. Psychiatry 2010; 18: 1–21

  • 104. Walczewski K. Wojciechowska A. Sieci społeczne pacjentów chorych na schizofrenię w trzy lata po pierwszej hospitalizacji. Porównanie grupy objętej programem leczenia środowiskowe-go z grupą z indywidualnym programem leczenia. Psychiatria Polska. 1998; 32(1): 59-69.

  • 105. Fehm-Wolfsdof G. Born J. Voigt KH. Fehm HL. Human memory and neurohypophyseal hormones: opposite effects of vasopressin and oxytocin. Psychoneuroendocrinol. 1984; 9(3): 285-292.

  • 106. Baumgartner T. Heinrichs M. Vonlanthen A. et al. Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron. 2008; 58(4): 693-650.

  • 107. Anderson-Hunt M. Dennerstein L. Drug points: increased female sexual response after oxytocin. BMJ. 1994: 309-928.

  • 108. Teltsh O. et al. Oxytocin and vasopressin genes are significantly associated with schizophrenia in a large Arab–Israeli pedigree. Int. J. Neuropsychopharmacol. 2012: 15 pp. 309-319.

  • 109. Bigdeli T. B. et al. Comprehensive gene-based association study of a chromosome 20 linked region implicates novel risk loci for depressive symptoms in psychotic illness. PloS one 2011 6.12: e21440.

  • 110. Gershon E. S.; Alliey-Rodriguez N.; Liu Ch. After GWAS: searching for genetic risk for schizophrenia and bipolar disorder. American Journal of Psychiatry 2011 168.3: 253-256.

  • 111. Montag C. et al. Association between oxytocin receptor gene polymorphisms and self-rated ‘empathic concern’in schizophrenia. PloS one 2012 7.12: e51882.

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