Platelet indices as potential biomarkers for determining active ulcerative colitis and assessing the efficacy of biological treatment – experience of a single centre – a pilot study

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Various laboratory parameters are commonly used to assess the efficacy of biological treatment (BT). The aim of our study was to assess the correlation between platelet (PLT) indices: (mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW)), C-reactive protein (CRP) and endoscopic picture in the course of infliximab induction regimen in ulcerative colitis (UC) patients. The study enrolled 46 patients with UC – 32 men and 16 women. They were administered infliximab (standard induction therapy). Laboratory tests (CRP and PLT indices) and colonoscopy were performed in all patients during the induction regimen – at 0, 2, and 6 weeks and in follow-up six weeks after the completion of induction therapy. The study revealed a statistically significant decrease in CRP and PLT, and an increase in MPV, together with improvement of endoscopic picture (p <0.001) (MAYO score, MAYO endoscopic subscore) in all patients. PCT and PDW values remained in normal ranges before BT and after the finish of the induction regimen. PCT correlated positively with CRP before the introduction of BT (p = 0.018). In addition, positive correlations between PCT and PLT count were noticed before infliximab induction regimen and in follow-up after the finished of therapy (p <0.001). Additionally, a negative correlation between PLT count and MPV prior to the first dose of infliximab was observed (p=0.032). Our data suggest that PLT indices could be useful biomarkers for determining active UC and for assessing the efficacy of BT. From what we know, this is the first survey devoted to PLT parameters in Polish patients with UC.

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  • 1. Voudoukis E Karmiris K Koutroubakis IE. Multipotent role of platelets in inflammatory bowel diseases: a clinical approach. World J Gastroenterol. 2014;20:3180-90.

  • 2. Giannotta M Tapete G Emmi G Silvestri E Milla M. Thrombosis in inflammatory bowel diseases: what’s the link? Thromb J. 2015;13:14.

  • 3. Budak YU Polat M Huysal K. The use of platelet indices plateletcrit mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Biochem Med (Zagreb) 2016;26:178–93.

  • 4. Ghoshal K Bhattacharyya M. Overview of platelet physiology: its hemostatic and nonhemostatic role in disease pathogenesis. Scientific World Journal. 2014;2014:781857.

  • 5. Öztürk ZA Dag MS Kuyumcu ME Cam H Yesil Y Yilmaz N et al. Could platelet indices be new biomarkers for inflammatory bowel diseases? Eur Rev Med Pharmacol Sci. 2013;17:334-41.

  • 6. Sobolewska A Włodarczyk M Stec-Michalska K Fichna J Wiśniewska-Jarosińska M. Mean platelet volume in Crohn’s disease patients predicts sustained response to a 52-week infliximab therapy: a pilot study. Dig Dis Sci. 2016;61:542-9.

  • 7. Lei JJ Zhou L Liu Q Xiong C Xu CF. Can mean platelet volume play a role in evaluating the severity of acute pancreatitis? World J Gastroenterol. 2017;23:2404-13.

  • 8. Choi DH Kang SH Song H. Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease. Korean J Intern Med. 2016;311009-17.

  • 9. Matowicka-Karna J Kamocki Z Polińska B Osaa J Kemona H. Platelets and inflammatory markers in patients with gastric cancer. Clin Dev Immunol. 2013;2013:401623.

  • 10. Li N Yu Z Zhang X Liu T Sun YX Wang RT et al. Elevated mean platelet volume predicts poor prognosis in colorectal cancer. Sci Rep. 2017;7:10261.

  • 11. Song X Zhu H Pei Q Tan F Li C Zhou Z et al. Significance of inflammation-based indices in the prognosis of patients with non-metastatic colorectal cancer. Oncotarget. 2017;8:45178-89.

  • 12. Li N Yu Z Zhang X Liu T Sun YX Wang RT et al. Elevated mean platelet volume predicts poor prognosis in colorectal cancer. Scientific Reports. 2017;7:10261.

  • 13. Ozturk N Baygutalp NK Bakan E Altas GF Polat H Dorman E. Changes in platelet parameters in leukocytosis. Afr Med J. 2016;24:185.

  • 14. Tang J Gao X Zhi M Zhou HM Zhang M Chen HW et al. Plateletcrit: a sensitive biomarker for evaluating disease activity in Crohn’s disease with low hs-CRP. J Dig Dis. 2015;16:118-24.

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