Application of mesenchymal stem cells in paediatrics

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Abstract

Mesenchymal stem cells (MSC) were described by Friedenstein in the 1970s as being a group of bone marrow non-hematopoietic cells that are the source of fibroblasts. Since then, knowledge about the therapeutic potential of MSCs has significantly increased. MSCs are currently used for the treatment of many diseases, both in adults and children. MSCs are used successfully in the case of autoimmune diseases, including rheumatic diseases, diabetes mellitus type 1, gastroenterological and neurological diseases. Moreover, treatment of such organ disorders as damage or hypoxia through application of MSC therapy has shown to be satisfactory. In addition, there are some types of congenital disorders, including osteogenesis imperfecta and Spinal Muscular Atrophy, that may be treated with cellular therapy. Most studies showed no other adverse effects than fever. Our study is an analysis that particularly focuses on the registered trials and results of MSCs application to under 18 patients with acute, chronic, recurrent, resistance and corticosteroids types of Graft-versus-Host Disease (GvHD). Stem cells currently play an important role in the treatment of many diseases. Long-term studies conducted on animals have shown that cell therapy is both effective and safe. The number of indications for use of these cells in the course of treatment of people is constantly increasing. The results of subsequent studies provide important data justifying the application of MSCs in the course of treatment of many diseases whose treatment is ineffective when utilizing other approaches.

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  • 1. Ahn S.Y. Chang Y.S. Park W.S.: Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage. Korean J Pediatr 57(6):251-62014. doi:

    • Crossref
    • Export Citation
  • 2. Bajek A. Olkowska J. Drewa T.: Mesenchymal stem cells as a therapeutic tool in tissue and organ regeneration. Postepy Hig Med Dosw 24;65:124-322011.

  • 3. Ball L.M. et al.: Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid-refractory grade III-IV acute graft-versus-host disease. Br J Haematol. 163(4):501-9. 2013. doi:

    • Crossref
    • Export Citation
  • 4. Barry F.P. et al.: The monoclonal antibody SH-2 raised against human mesenchymal stem cells recognizes an epitope on endoglin (CD105). Biochem Biophys Res Commun 265(1):134-9 1999.

  • 5. Boruczkowski D. Korytowska-Niklas A. Bręborowicz A.: Zastosowanie komórek macierzystych w terapii chorób układu oddechowego - możliwości i nadzieje. Alergia Astma Immunologia 18 (3): 170-174 2013.

  • 6. Boruczkowski D. et al.: Krew pępowinowa. Część trzecia - przyszłość [Cord blood. Part three - the future]. Nowa Pediatria 3:61-65 2011.

  • 7. Caplan A.I.: Mesenchymal stem cells. J Orthop Res 9(5):641-50 1991.

  • 8. Chang Y.S. et al.: Mesenchymal stem cells for bronchopulmonary dysplasia: phase 1 dose-escalation clinical trial. J Pediatr 164(5):966- 972 2014. e6. doi:

    • Crossref
    • Export Citation
  • 9. Chicha L. Smith T. Guzman R.: Stem cells for brain repair in neonatal hypoxia-ischemia. Childs Nerv Syst 30(1):37-462014. doi:

    • Crossref
    • Export Citation
  • 10. Ciccocioppo R. et al.: Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn’s disease. Gut 60(6):788-98 2011. doi:

    • Crossref
    • Export Citation
  • 11. Dalal J Gandy K Domen J.: Role of mesenchymal stem cell therapy in Crohn’s disease. Pediatr Res 71(4 Pt 2):445-51 2012. doi:

    • Crossref
    • Export Citation
  • 12. Dominici M. et al.: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8(4):315-72006.

  • 13. Fang B et al.: Cotransplantation of haploidentical mesenchymal stem cells to enhance engraftment of hematopoietic stem cells and to reduce the risk of graft failure in two children with severe aplastic anemia. Pediatr Transplant 13(4):499-5022009. doi:

    • Crossref
    • Export Citation
  • 14. Farivar S. et al.: Neural differentiation of human umbilical cord mesenchymal stem cells by cerebrospinal fluid. Iran J Child Neurol 9(1):87-93 2015.

  • 15. Friedenstein A.J. et al.: Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation 17(4):331-40 1974.

  • 16. Gentili C. Torre M. Cancedda R.: Tissue engineering approaches in skeletal pediatric disorders. Eur J Pediatr Surg 24(3):263-9 2014. doi:

    • Crossref
    • Export Citation
  • 17. Gortner L. et al.: Regenerative therapies in neonatology: clinical perspectives. Klin Padiatr 224(4):233-40 2012.

  • 18. Götherström C. et al.: Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience. Stem Cells Transl Med 3(2):255-64 2014. doi:

    • Crossref
    • Export Citation
  • 19. Heijnen C.J. Witt O. Wulffraat N. Kulozik A.E.: Stem cells in pediatrics: state of the art and future perspectives. Pediatr Res 71(4 Pt 2):407-92012. doi:

    • Crossref
    • Export Citation
  • 20. Hibi H. Yamada Y. Ueda M. Endo Y.: Alveolar cleft osteoplasty using tissue-engineered osteogenic material. Int J Oral Maxillofac Surg 35(6):551-52006.

  • 21. Hu J. et al.: Long term effects of the implantation of Wharton’s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus. Endocr J 60(3):347-57 2013.

  • 22. Introna M. et al.: Treatment of graft versus host disease with mesenchymal stromal cells: a phase I study on 40 adult and pediatric patients. Biol Blood Marrow Transplant. 20(3):375-81 2014. doi:

    • Crossref
    • Export Citation
  • 23. Jin J.L. et al.: Safety and efficacy of umbilical cord mesenchymal stem cell therapy in hereditary spinocerebellar ataxia. Curr Neurovasc Res 10(1):11-202013.

  • 24. Jozwiak S. et al.: Intracerebroventricular Transplantation of Cord Blood-Derived Neural Progenitors in a Child With Severe Global Brain Ischemic Injury. Cell Medicine 12:71-802010.

  • 25. Jung J.W. et al.: Familial occurrence of pulmonary embolism after intravenous adipose tissue-derived stem cell therapy. Yonsei Med J 54(5):1293-6 2013. doi:

    • Crossref
    • Export Citation
  • 26. Krenska A. et al.: The use of mesenchymal stem cells in therapy of steroid-resistance chronic refractory graft-versus-host disease after hematopoietic stem cell transplantation. Medical and Biological Sciences 28 3 57-61 2014.

  • 27. Kurtzberg J. et al.: Allogeneic human mesenchymal stem cell therapy (remestemcel-L Prochymal) as a rescue agent for severe refractory acute graft-versus-host disease in pediatric patients. Biol Blood Marrow Transplant 20(2):229-35 2014. doi:

    • Crossref
    • Export Citation
  • 28. Lacis A. Erglis A.: Intramyocardial administration of autologous bone marrow mononuclear cells in a critically ill child with dilated cardiomyopathy. Cardiol Young 21(1):110-2 2011. doi:

    • Crossref
    • Export Citation
  • 29. Le Blanc K. et al.: Developmental Committee of the European Group for Blood and Marrow Transplantation. Mesenchymal stem cells for treatment of steroid-resistant severe acute graft-versus-host disease: a phase II study. Lancet 10;371:1579-86 2008. doi:

    • Crossref
    • Export Citation
  • 30. Liang J. et al.: Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis 69(8):1423-9 2010. doi:

    • Crossref
    • Export Citation
  • 31. Lv Y.T. et al.: Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism. J Transl Med 27;11:196 2013. doi:

    • Crossref
    • Export Citation
  • 32. Mei S.H. et al.: Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med 15;182(8):1047-57 2010. doi:

    • Crossref
    • Export Citation
  • 33. Norambuena G.A. Khoury M. Jorgensen C.: Mesenchymal stem cells in osteoarticular pediatric diseases: an update. Pediatr Res 71 (4Pt2):452-8 2012. doi:

    • Crossref
    • Export Citation
  • 34. Pal R. et al.: Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study. Cytotherapy 11(7):897-911 2009. doi:

    • Crossref
    • Export Citation
  • 35. Pesmatzoglou M. Dimit r iou H. St iakaki E .: Could mesenchymal st romal cel ls have a role in chi ldhood autoimmune diseases? Immunol Invest 42(7):639-56. 2013. doi:

    • Crossref
    • Export Citation
  • 36. Prasad V.K. et al.: Efficacy and safety of ex vivo cultured adult human mesenchymal stem cells (Prochymal™) in pediatric patients with severe refractory acute graft-versus-host disease in a compassionate use study. Biol Blood Marrow Transplant 17(4):534-41 2011. doi:

    • Crossref
    • Export Citation
  • 37. Selem S.M. Kaushal S. Hare J.M.: Stem cell therapy for pediatric dilated cardiomyopathy. Curr Cardiol Rep 15(6):369 2013. doi:

    • Crossref
    • Export Citation
  • 38. Sun L. et al.: Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum 62(8):2467-75 2010. doi:

    • Crossref
    • Export Citation
  • 39. Sun Y. Zhang F.S. Zhang Z.Y.: Immunoregulatory effect of bone marrow mesenchymal stem cells on regulatory T cells in patients with systemic lupus erythematosis. Zhonghua Nei Ke Za Zhi 46(12):1018-21 2007.

  • 40. Tyndall A.: Application of autologous stem cell transplantation in various adult and pediatric rheumatic diseases. Pediatr Res 71(4 Pt 2):433-8 2012. doi:

    • Crossref
    • Export Citation
  • 41. van Velthoven C.T. Gonzalez F. Vexler Z.S. Ferriero D.M.: Stem cells for neonatal stroke- the future is here. Front Cell Neurosci 25;8:207 2014. doi:

    • Crossref
    • Export Citation
  • 42. Vassena R. et al.: ESHRE special interest group Stem Cells. Stem cells in reproductive medicine: ready for the patient? Hum Reprod 30(9):2014-21 2015. doi:

    • Crossref
    • Export Citation
  • 43. Wakitani S. et al.: Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports. Cell Transplant 13(5):595-600 2004.

  • 44. Wernicke C.M. et al.: Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases. Int Arch Med 15;4(1):27 2011.doi:

    • Crossref
    • Export Citation
  • 45. Wong R.S.Y. Mesenchymal stem cells: Angels or demons? J of Biomed Biotechnol 459510 2011. doi.org/10.1155/2011/459510

  • 46. www.clinicaltrials.gov

  • 47. Zheng J.C. Tong Z.: Exciting progresses in stem cell and neural stem cell research. Curr Mol Med 13(9):1409-11 2013.

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