Littoral cell angioma mimicking metastatic tumors

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Littoral cell angioma is a rare primary, vascular tumor thought to originate from the endothelial cells lining the sinuses of the splenic red pulp (the “littoral cells”). It is a benign, usually asymptomatic lesion diagnosed incidentally. Ultrasound and tomography appearance is not characteristic and histopathological examination is required. This work provides a case-study of littoral cell angioma which was seen in a 55-year-old female who complained of non-specific upper abdominal pain. Computed tomography revealed multiple hypo-attenuated splenic lesions suggestive for metastasis. A splenectomy was performed and routine microscopic examination supported by immunohistochemistry reactions with CD68, CD34 and CD31 showed littoral cell angioma.

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  • 1. Bisceglia M. Sickel J.Z. Giangaspero F. et al.: Littoral cell angioma of the spleen: an additional report of four cases with emphasis on the association with visceral organ cancers. Tumori. 84 595 1998.

  • 2. Collins G.L. Morgan M.B. Taylor F.M.: Littoral cell angiomatosis with poorly differentiated adenocarcinoma of the lung. Ann Diagn Pathol. 7 54 2003.

  • 3. Compérat E. et al.: Splenic metastases: clinicopathologic presentation differential diagnosis and pathogenesis. Arch Pathol Lab Med.131965 2007.

  • 4. Falk S. Stutte H.J. Frizzera G.: Littoral cell angioma. A novel splenic vascular lesion demonstrating histiocytic differentiation. Am J Surg Pathol. 15 1023 1991.

  • 5. Forest F. et al.: Traumatic subcapsular splenic hematoma revealing littoral cell angioma and Gaucher’s disease. Ann Hematol.8910612010.

  • 6. Gupta M.K. et al.: Littoral cell angioma of the spleen in a patient with Gaucher disease. Am J Hematol.68612001.

  • 7. Gupta P. et al.: Littoral cell angioma of spleen: an uncommon presentation of a rare neoplasm. J Clin Imaging Sci. 2 69 2012.

  • 8. Harmon R.L. Cerruto C.A. Scheckner A.: Littoral cell angioma: a case report and review. Surg. 63 345 2006.

  • 9. Johansson J. Björnsson B. Ignatova S. et al.: Littoral cell angioma in a patient with Crohn’s disease. Case Rep Gastrointest Med. 2015:474969. doi: 10.1155/2015/474969.

  • 10. Liang W. et al.: Littoral cell angioma mimicking hepatic tumor. Acta Radiol Short Rep. 2012. doi: 10.1258/arsr.2012.120031.

  • 11. Lin C.H. Yu J.C. Shih M.L. et al.: Littoral cell angioma of the spleen in a patient with hepatocellular carcinoma. J Formos Med Assoc. 104 282 2005.

  • 12. Steensma D. Morice W.: Littoral cell angioma associated with portal hypertension and resected colon cancer. Acta Haematol. 104 131 2000.

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