The prevalence of Beta Hemolytic Streptococcus in a Children’s Tertiary Care Hospital in Timisoara

Ana Antoaneta Bobia 1 , Oana Alexandra Blaj 1 , Denis Oancea 1 , Bagiu Iulia-Cristina 1 , Bagiu Radu-Vasile 1 , Horhat Delia-Ioana 1 , Laurentiu Pirtea 1 , Silvia Matinca 1 , Amel Isaq 1  und Ioana Ciuca 1
  • 1 “Victor Babeș” University of Medicine and Pharmacy, , 300041, Timișoara, Romania


Background. Beta hemolytic streptococcus (BHS) represents a worldwide health problem because of the complications that can occur. Thus, it is important to identify the presence and type of BHS in time to start treatment if needed, avoiding the complications.

Aim. Our aim was to identify the prevalence of Beta Hemolytic Streptococcus in a Children’s Tertiary Care Hospital in Timisoara.

Methods. A cross-sectional study was conducted from April-June 2018 in Emergency Hospital for Children Timisoara. The study lot consists from 1100 children, ages between 0-18 years, which were not given, in the preceding two weeks, any antibiotics. We compared the study with two studies from different cities in Nepal, with the same subject as ours. Group A and Group C Streptococci were identified by beta hemolytic colonies, bacitracin sensitivity, catalase negativity test and latex agglutination test (Oxoid Streptococcal Grouping kit). ASO (Antistreptolysin O) test was also performed from serum samples, for patients with positive cultures. We also tested the antibiotic sensitivity to: Cefepime, Clindamycin, Erythromycin, Tetracycline.

Results. The prevalence of BHS (Beta Hemolytic Streptococcus), especially GABHS (Group A Beta Hemolytic Streptococcus) was 4%, in children from a tertiary care hospital in Timisoara, Romania; which is comparable to the findings of similar studies. In the first study, the prevalence of GABHS was 7.2%, and in the second study was 9%. The patients with positive cultures were also tested for ASO, 28 patients (52%) had high levels, while 26 (48%) had normal levels. On all positive patients an antibiogram was made and we observed that most of the isolates were sensitive to the antibiotics used. A few isolates in Group A were resistant.

Conclusions. Considering the limited data found on our subject, further epidemiological studies on streptococcal disease complex are needed.

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  • 1. Anon. Nosocomial group A streptococcal infections associated with asymptomatic health-care workers - Maryland and California. MMWR 1997

  • 2. Cynthia S. Hayes, Harold Williamson. Management of Group A Beta-Hemolytic Streptococcal Pharyngitis. Am Fam Physician. 2001 Apr 15;63(8):1557-1565

  • 3. Roxana Moldovan. Practical Bacteriology. Mirton. Timisoara.1998

  • 4. Manandhar A, Shah Y, Shrestha J. Study on the Prevalence of Beta Haemolytic Streptococcus Among School Children. J Nepal Paediatr Soc. 2013;33(1):45-47

  • 5. Patterson MJ. Streptococcus. Medical Microbiology. 4th edition. Galveston, 1996.

  • 6. M.S.Sahin, M.U.Yalcin, D.Kocyigit. Prevalence of rheumatic heart disease in patients with recurrent tonsillitis and elevated anti-streptolysin O titers. International Journal of Pediatric Otorhinolaryngology. October 2016; 89:133-135

  • 7. Delia Muntean, Florin-George Horhat, Luminița Bădițoiu, Victor Dumitrașcu, Iulia-Cristina Bagiu, Delia-Ioana Horhat et. al. Multidrug-Resistant Gram-Negative Bacilli: A Retrospective Study of Trends in a Tertiary Healthcare Unit. Medicina 2018;54(6), 92

  • 8. Tsegahun Asfaw, Demissew Shenkute, Mihret Tilahun, Nigus Zegeye. Evaluation of Antistreptolysin O (ASO) Titer in Rheumatoid Heart Disease Debre Berhan Referral Hospital, Ethiopia.Clinical Medicine Research 2018; 7(1): 26-29

  • 9. Shaikh N, Leonard E, Martin JM. Prevalence of Streptococcal Pharyngitis and Streptococcal Carriage in Children: A Meta-analysis. Pediatrics. 2010;126(3):557-564.

  • 10. Hurst JR, Kasper KJ, Sule AN, McCormick JK. Streptococcal pharyngitis and rheumatic heart disease: the superantigen hypothesis revisited. Infect Genet Evol. 2018;61(March):160-175.

  • 11. Bonofiglio L, Gagetti P, García Gabarrot G, et al. Susceptibility to β-lactams in β-hemolytic streptococci. Rev Argent Microbiol. 2018

  • 12. Carapetis JR, Steer AC, Mulholland EK, Weber M. The global burden of group A streptococcal diseases. Lancet Infect Dis. 2005;5(11):685-694.

  • 13. Brook I. Brief Report A Pooled Comparison of Cefdinir and Penicillin in the Treatment of Group A beta-hemolytic Streptococcal Pharyngotonsillitis. 2005:3-10.

  • 14. Woodwell DA, Cherry DK. National Ambulatory Medical Care Survey: 2002 summary. Adv Data. 2004;(346):1-44.

  • 15. Bisno AL, Gerber MA, Gwaltney, Jr. JM, Kaplan EL, Schwartz RH, Infectious Diseases Society of America. Practice Guidelines for the Diagnosis and Management of Group A Streptococcal Pharyngitis. Clin Infect Dis. 2002;35(2):113-125.

  • 16. Cunningham MW. Pathogenesis of group A streptococcal infections. Clin Microbiol Rev. 2000;13(3):470-511.

  • 17. Shrestha L, Khattri J B K, Brahmadathan K N, Nagra J S, Prevalence Of Streptococcal Pharyngitis Among School Children Of Pokhara Valley, Nepal, Journal of Nepal Medical Association, 2001:41:253-257


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