Magnesium supplements affect selected cadmium toxic actions and uptake of repeated doses of cadmium

Andrzej Grosicki 1 , Paweł Małagocki 1 , Anna Kycko 2 , Jerzy Monkiewicz 3 , and Waldemar Korol 4
  • 1 Department of Radiobiology, National Veterinary Research Institute. 24-100 Pulawy, Poland
  • 2 Department of Pathology, National Veterinary Research Institute. 24-100 Pulawy, Poland
  • 3 Department of Genetics, Wroclaw University of Environmental and Life Sciences, 51-631 Wroclaw, Poland
  • 4 National Laboratory for Feedingstuffs, National Research Institute of Animal Production, 20-079 Lublin, Poland


The importance of magnesium supplements on organ retention of cadmium and allometric parameters after repeated exposure to cadmium chloride were studied in male Wistar rats. Magnesium chloride was given via drinking water (500 mg Mg/L) to rats exposed intragastrically to cadmium chloride (labelled with cadmium 109) at a daily dose corresponding to 25 mg/kg diet for 7, 14, 21, and 28 d. Supplements of magnesium temporarily decreased cadmium retention in the duodenum and liver. No significant differences in cadmium retention were evidenced in the kidneys and testicles. The supplements of magnesium also retain more of the body weight gains and restore the relative liver and testicle weight in rats intoxicated with cadmium. Comparison of the present results with earlier reports suggests a relationship between doses of magnesium and cadmium; higher doses of cadmium need more magnesium to overcome toxic action of the heavy metal.

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