Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours
, , , , and | Jul 03, 2015
Published Online: Jul 03, 2015
Page range: 247 - 253
Received: Dec 19, 2014
Accepted: Jun 03, 2015
DOI: https://doi.org/10.1515/bvip-2015-0037
© 2015 National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
The aim of the study was to assess the microvessel density based on the analysis of the expression of the CD31, VEGF, and LIMS-1 proteins in canine mast cell tumours. The study was conducted on 60 mastocytomas; 16 cases were classified as the grade I, 26 as the grade II, and 18 as the grade III. Statistical analysis showed a positive correlation only between the grade of the tumour and the expression of LIMS-1. In conclusion, LIMS-1 could be successfully used as a prognostic endothelial cell marker in mast cell tumour. CD31 may be a useful marker, but further examinations are necessary. VEGF is not recommended