Effect of 28-Day Exposure to Fenpropathrin on the Activities of Serum Alanine Transaminase and Liver Antioxidant Enzymes in Mice
and | Apr 01, 2015
Published Online: Apr 01, 2015
Page range: 165 - 169
Received: Oct 30, 2014
Accepted: Mar 03, 2015
DOI: https://doi.org/10.1515/bvip-2015-0025
© 2015 National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Fenpropathrin (FEN) was administered intraperitoneally in doses of 2.38 mg/kg, 5.9 5mg/kg, or 11.9 mg/kg b.w. to mice for 28 consecutive days. FEN did not significantly affect the activity of alanine transaminase (ALT) in the sera. Superoxide dismutase and glutathione peroxidase activities were significantly elevated in the liver after a 28-d exposure to moderate or highest doses of the pesticide. These results demonstrate that the 28-day exposure to FEN leads to an up-regulation of expression of antioxidant enzymes in response to an oxidative stress in mouse liver without causing a significant increase in ALT activity.