Pathomorphological Changes of the Myocardium in Canine Dilated Cardiomyopathy (DCM)

Open access

Abstract

The study was conducted on ventricular and atrial wall preparations from 11 dogs with clinically diagnosed dilated cardiomyopathy. After fixation, the specimens were stained with haematoxylin and eosin and Masson-Goldner trichrome technique. Parenchymal changes (fibrosis and fatty infiltration), vascular changes (congestion and coronary vessel wall hypertrophy), degenerative changes (loss of striation, changes in cardiomycyte and nuclei structure), and presence of inflammatory infiltrates (mononuclear and polynuclear) were estimated. Complex histological changes in both ventricular and atrial muscles were shown. It was not determined whether the processes occurring in the myocardium have a primary character, or are a consequence of developing heart failure. Such issues will be put under further and more detailed examination.

1. Dambach D.M, Lannon A., Sleeper M.M, Buchanan J.: Familial dilated cardiomyopathy of young Portuguese Water Dogs. J Vet Intern Med 1999, 13, 65-71.

2. Dukes-McEwan J, Borgarelli M, Tidholm A., Vollmar A.C, Häggström J.: Proposed guidelines for the diagnosis of canine idiopathic dilated cardiomyopathy. J Vet Cardiol 2003, 11, 7-19.

3. Everett R.M., McGann J, Wimberly H.C., Althoff J.: Dilated cardiomyopathy of Doberman Pinschers: retrospective histomorphologic evaluation of heart from 32 cases. Vet Pathol 1999, 36, 221-227.

4. Liu P.P., Mak S, Steward D.J.: Potential role of the microvasculature in progression of heart failure. Am J Cardiol 1999, 84, 23-26.

5. Lobo L, Carvalheira J, Canada N, Bussadori C, Gomes J.L., Faustino A.M.R.: Histologic characterization of dilated cardiomyopathy in Estrela Mountain Dogs. Vet Pathol 2010, 47, 637-642.

6. Maron B.J., Wolfson J.K., Epstein S.E., Roberts W.C.: Intramural (“small vessel”) coronary artery disease in hypertrophic cardiomyopathy. J Am Coll Cardiol 1986, 8, 545-557.

7. Marti V., Aymat R, Ballester M, Garcia J, Carrio I, Auge J.M.: Coronary endothelial dysfunction and myocardial cell damage in chronic stable idiopathic dilated cardiomyopathy. Int J Cardiol 2002, 82, 237-245.

8. Neglia D., L'Abbate A.: Coronary microvascular dysfunction and idiopathic dilated cardiomyopathy. Pharmacol Rep 2005, 57, 151-155.

9. Schaper J., Kostin S, Hein S, Elsässer A., Arnon E., Zimmermann R.: Structural remodelling in heart failure. Exp Clin Cardiol 2002, 7, 64-68.

10. Scholz D, Diener W, Schaper J.: Altered nucleus/cytoplasm relationship and degenerative changes in human dilated cardiomyopathy. Cardioscience 1994, 5, 127-138.

11. Sharov V.G., Kostin S., Todor A., Schaper J, Sabbah H.N.: Expression of cytoskeletal, linkage and extracellular proteins in failing dog myocardium. Heart Fail Rev 2005, 10, 297-303.

12. Tidholm A, Häggström J. Jönsson L.: Detection of attenuated wavy fibers in the myocardium of Newfoundlands without clinical or echocardiographic evidence of heart disease. Am J Vet Res 2000, 61, 238-241.

13. Tidholm A, Häggström J, Borgarelli M, Tarducci A.: Canine idiopathic dilated cardiomyopathy. Part I: aetiology, clinical characteristics, epidemiology and pathology. Vet J 2001, 162, 92-107.

14. Tidholm A., Jönsson L.: Histologic characterization of canine dilated cardiomyopathy. Vet Pathol 2005, 42, 1-8.

15. Treasure C.B, Vita J.A, Cox D.A, Fish R.D, Gordon J.B, Mudge G.H., Colucci W.S., Sutton M.G, Selwyn A.P., Alexander R.W.: Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy. Circulation 1990, 81, 772-779.

16. Tuomainen P.O., Magga J, Fedacko J, Kärkkäinen S, Miettinen K., Vanninen E., Kuusisto J, Peuhkurinen K.J.: Idiopathic dilated cardiomyopathy and chronic atrial fibrillation. Clin Physiol Funct Imaging 2014, 34, 133-137.

17. Van den Heuvel A.F.M, Van Veldhuisen D.J., Van der Wall E.E, Blanksma P.K., Siebelink H.M.J., Vaalburg W.M, van Gilst W.H, Crijns H.J.G.M.: Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischemia in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 2000, 35, 19-28.

18. Vollmar A., Fox P.R., Meurs K.M, Liu S.K.: Dilated cardiomyopathy in juvenile Doberman Pinschers. J Vet Cardiol 2003, 5, 23-27.

19. Zhou Y.L, Li X.L., Zhang H.F., Yao W.M, Tong M, Xu Q, Cao K.J, Huang J.: Decreased small arterial compliance with increased serum vascular endothelial growth factor-A and circulating endothelial progenitor cell in dilated cardiomyopathy. Chin Med J 2008, 121, 316-320.

Bulletin of the Veterinary Institute in Pulawy

The Journal of National Veterinary Research Institute in Pulawy

Journal Information


IMPACT FACTOR 2017: 0.811
5-year IMPACT FACTOR: 0.973

CiteScore 2017: 0.68


SCImago Journal Rank (SJR) 2017: 0.287
Source Normalized Impact per Paper (SNIP) 2017: 0.484

Cited By

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 306 256 21
PDF Downloads 130 117 10