Effect of a Diet Composed of Genetically Modified Feed Components on the Selected Immune Parameters in Pigs, Cattle, and Poultry

Dariusz Bednarek 1 , Katarzyna Dudek 1 , Krzysztof Kwiatek 2 , Małgorzata Świątkiewicz 3 , Sylwester Świątkiewicz 3 , und Juliusz Strzetelski 3
  • 1 Department of Cattle and Sheep Diseases National Veterinary Research Institute, 24-100 Pulawy, Poland
  • 2 Department of Hygiene of Feedingstuffs, National Veterinary Research Institute, 24-100 Pulawy, Poland
  • 3 Department of Animal Nutrition and Feed Science, National Research Institute of Animal Production, 32-083 Balice, Poland


The aim of the study was to evaluate the immune effects of genetically modified (GM), insect resistant corn (MON810) expressing toxin protein of Bacillus thuringiensis, and glyphosate-tolerant soybean meal (Roundup Ready MON-40-30-2), which are used as the feed mixture components in domestic animals. The study was conducted on 60 pigs (36 fatteners and 24 sows), 20 calves, 40 broilers, and 40 laying hens. Each species was divided into four basic nutritional groups: group I (control) - conventional feed, group II - feed consisted of GM soybean meal and non-modified corn, group III - non-modified soybean meal and GM corn, group IV - GM soybean meal and GM corn. Moreover, in the experiment on fatteners two additional groups were formed: group V - animals fed both conventional soybean meal and bruised grain, and group VI - GM soybean meal and conventional bruised grain. The results of study did not reveal any significant effect of feed mixtures containing GM components on the immune response in all animals regardless of their species and technological producing groups.

Falls das inline PDF nicht korrekt dargestellt ist, können Sie das PDF hier herunterladen.

  • 1. American Academy of Environmental Medicine Calls for Immediate Moratorium on Genetically Modified Foods, position paper http://aaemonlineorg/gmopost.html, and press advisory, http://www.aaemonline.org/gmopressrelease.html Retrieved 12/12/12.

  • 2. Aurlich K., Bohme H., Daenicke R., Halle I.T., Flachowsky G.: Genetically modified feeds in animal nutrition. Bacillus thuringiensis (Bt) corn in poultry, pig and ruminant nutrition. Arch Anim Nutr 2003, 54, 183-195.

  • 3. Carter J.N., Meredith G.L., Montelongo M., Gill D.R., Krehbiel C.R., Payton M.E.: Realationship of vitamin E supplementation and antimicrobial treatment with acutephase protein responses in cattle affected by naturally acquired respiratory tract disease. Am J Vet Res 2002, 63, 1111-1117.

  • 4. Chowdhury E.H., Kuribara H., Hino A., Sultana P., Mikami O., Shimada N., Guruge K.S., Saito M., Nakajima Y.: Detection of corn intrinsic and recombinant DNA fragments and Cry1Ab protein in the gastrointestinal contents of pigs fed genetically modified corn Bt11. J Anim Sci 2003, 81, 2546-2551.

  • 5. Cromwell G.L., Lindemann M.D., Randolph J.H., Parker G.R., Coffey R.D., Laurent K.M., Armstrong C.L., Mikel W.B., Stanisiewski E.P., Hartnell G.F.: Soybean meal from Roundup Ready or conventional soybeans in diets for growing-finishing swine. J Anim Sci 2002, 80, 708-715.

  • 6. Flachowsky G., Chesson A., Aulrich K.: Animal nutrition with feeds from genetically modified plants. Arch Anim Nutr 2005, 59, 1-40.

  • 7. Gaines A.M., Allee G.L., Ratliff B.W.: Swine digestible energy evaluation of Bt (MON810) and Roundup Ready corn compared with commercial varieties. J Anim Sci 2001, 79, 109.

  • 8. Ganheim C., Hulten C., Carlsson U., Kindahl H., Niskanen R., Waller K.P.: The acute phase response in calves experimentally infected with bovine viral diarrhoea virus and/or Mannheimia haemolytica. J Vet Med B 2003, 50, 183-190.

  • 9. Hammond B.G., Vicini J.L., Hartnell G.F., Naylor M.W., Knight Ch.D., Robinson E.H., Fuchs R.L., Padgette S.R.: The feeding value of soybeans fed to rats, chickens, catfish and dairy cattle is not altered by genetic incorporation of glyphosate tolerance. J Nutr 1996, 126, 717-727.

  • 10. Heegaard P.M.H., Godson D.L., Toussaint M.J.M., Tjornehoj K., Larsen L.E., Viuff B.: The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory syncytial virus. Vet Immunol Immunopathol 2000, 77, 151-159.

  • 11. Krzyżowska M., Wincenciak M., Winnicka A., Baranowski A., Jaszczak K., Zimny J., Niemiałtowski M.: The effect of multigenerational diet containing genetically modified triticale on immune system in mice. Pol J Vet Sci 2010, 13, 423-430.

  • 12. Nikunen S., Härtel H., Orro T., Neuvonen E., Tanskanen R., Kivelä S.L., Sankari S., Aho P., Pyörälä S., Saloniemi H., Soveri T.: Association of bovine respiratory disease with clinical status and acute phase proteins in calves. Comp Immun Microbiol Infect Dis 2007, 30, 143-151.

  • 13. Padgette S.R., Taylor N.B., Nida D.L., Bailey M.R., MacDonald J., Holden L.R., Fusch R.L.: The composition of glyphosate-tolerant soybean seeds is equivalent to that of conventional soybeans. J Nutr 1996, 126, 702-716.

  • 14. Raman U., Poland R.L.: A new micro-quantitative nitro blue tetrazolium test. Pediatr Res 1975, 9, 334-336.

  • 15. Scholtz N.D., Halle I., Dänicke S., Hartmann G., Zur B., Sauerwein H.: Effects of an active immunization on the immune response of laying Japanese quail (Coturnixcoturnix japonica) fed with or without genetically modified Bacillus thuringiensis-maize. Poult Sci 2010, 89, 1122-1128.

  • 16. Sieradzki Z., Walczak M., Kwiatek K.: Occurrence of genetically modified maize and soybean in animal feedingstuffs. Bull Vet Inst Pulawy 2006, 52, 567-570.

  • 17. Stadnik J., Karwowska M., Dolatowski Z.J., Świątkiewicz M., Kwiatek K.: Effect of genetically modified feeds on physico-chemical properties of pork. Ann Anim Sci 2011, 11, 597-606.

  • 18. Ślopek S.: Immunologia praktyczna. PZWL, Warszawa, 1970.

  • 19. Świątkiewicz M., Hanczakowska E., Twardowska M., Mazur M., Kwiatek K., Kozaczyński W., Świątkiewicz S., Sieradzki Z.: Effect of genetically modified feeds on fattening results and transfer of transgenic DNA to swine tissues. Bull Vet Inst Pulawy 2011, 55, 121- 125.

  • 20. Świątkiewicz S., Koreleski J.: Genetically modified plants in poultry nutrition. Med Weter 2008, 64, 1379-1383.

  • 21. Walsh M.C., Buzoianu S.G., Gardiner G.E., Rea M.C., Gelencsér E., Jánosi A., Epstein M.M., Ross R.P., Lawlor P.G.: Fate of transgenic DNA from orally administered Bt MON810 maize and effects on immune response and growth in pigs. Plos One 2011, 6, 1-12.


Zeitschrift + Hefte