Seminoma, Sertolioma, and Leydigoma in Dogs: Clinical and Morphological Correlations

Open access


The study aimed at presenting the most frequent male gonadal tumours in dogs, their clinical and histopathological aspects, at outlining aetiopathogenesis and differential diagnosis of the tumours. As examples of the most frequently manifested testicular tumours, three clinical cases were presented, involving tumour of interstitial (Leydig) cells, tumour of Sertoli cells, and seminoma. Respective clinical diagnosis employed USG, X-ray patterns, and morphological and biochemical tests. The surgically sampled material was stained with H+E and an attempt was made to establish expression of E-cadherin, calretinin, and Ki-67. It was shown that histopathological diagnosis of testicular tumours in dogs is frequently very difficult and complex and requires multidirectional studies.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Barrand K.R. Scudamore C.L.: Canine hypertrophic osteoarthropathy associated with a malignant Sertoli cell tumour. J Small Anim Pract 2001 42 143-145.

  • 2. Bazzo R. Sarli G. Mandrioli L. Maecato P.S.: Sertoli cell tumour with Call-Exner-like bodies in a dog. J Vet Med A Physiol Pathol Clin Med 2002 49 535-537.

  • 3. Benazzi C. Sarli G. Brunetti B.: Sertoli cell tumour in a cat. J Vet Med A Physiol Pathol Clin Med 2004 51 124-126.

  • 4. Chaganti R.S.K. Houldsworth J.: Genetic and biology of adult human male germ cell tumors. Cancer Res 2000 60 1475-1482.

  • 5. Coupland C.A.C. Chilvers C.E.D. Davey G. Pike M.C. Oliver R.T.D. Forman D.: Risk factors for testicular germ cell tumours by histological tumour type. Br J Cancer 1999 80 1859-1863.

  • 6. Gawlik-Jakubczak T. Krajka K.: A case of nonseminomatous testis tumor. Przegl Lek 2004 61 528-534. Gorolla A. Terlin A. Vinanzi C. Roverato A. Sotti G. Antibani W. Foresta C.: Molecular analysis of the androgen receptor gene in testicular cancer. Endocr Relat Cancer 2005 12 645-655.

  • 7. Gorolla A. Terlin A. Vinanzi C. Roverato A. Sotti G. Antibani W. Foresta C.: Molecular analysis of the androgen receptor gene in testicular cancer. Endocr Relat Cancer 2005 12 645-655.

  • 8. Grieco V. Riccardi E. Greppi G.F. Teruzzi F. Iermano V. Finazzi M.: Canine testicular tumours: a study on 232 dogs. J Comp Path 2008 138 86-89.

  • 9. Hemminki K. Sweden L.X.: Familial risk in testicular cancer as a clue to heritable and environmental aetiology. Br J Cancer 2004 90 1765-1770.

  • 10. Highman W.J. Oliver R.T.D.: Diagnosis of metastases from testicular germ cell tumours using fine needle aspiration cytology. J Clin Pathol 1987 40 1324-1333.

  • 11. Kasper D.L. Braunwald E. Fauci A. Hauser S. Longo D. Jameson J.L.: Harrison’s principles of internal medicine. Mc Graw-Hill Professional New York 2004 pp. 550-553.

  • 12. MacLachlan N.J. Kennedy P.C.: Tumors of the genital system. In: Tumors in Domestic Animals editor Meuten D.J. Iowa State Press Iowa 2002 pp. 547-573.

  • 13. Maiolino P. Restucci B. Paparella S. Paciello O. De Vico G.: Correlation of nuclear morphometric features with animal and auman World Health Organization international histological classification of canine spontaneus seminomas. Vet Pathol 2004 41 608-611.

  • 14. Malicka E. Piusiński W. Sendecka H. Kielecki W. Osińska B. Lenartowicz-Kubrat Z.: Tumors in dogs in anatomopathological researches since 1985 to 1993. Medycyna Wet 1996 52 103-106.

  • 15. Masserdotti C. Bonfanti U. De Lorenzi D. Tranquillo M. Zanetti O.: Cytologic features of testicular tumours in dog. J Vet Med A Physiol Pathol Clin Med 2005 52 339-346.

  • 16. Matveev B.P. Gurarii L.L.: Leydig-cell tumors of the testis. Urol Nefrol 1997 4 34-36.

  • 17. May K.A. Moll H.D. Duncan R.B. Pleasant R.S. Purswell B.J.: Unilateral Leydig cell tumour resulting in acute colic and scrotal swelling in stallion with descended testes. Equine Vet J 1999 31 343-345.

  • 18. Meuten D.J.: Tumors in domestic animals. Iowa State Press Iowa 2002 pp. 561-573.

  • 19. Michalska Z. Michalski Z.: Prevalence of neoplasms in domestic animals in Wrocław and Lower Silesia during 1976-1995. Medycyna Wet 1997 53 263-267.

  • 20. Mischke R. Meurer D. Hoppen H.O. Ueberschar S. Hewicker-Trautwein M.: Blood plasma concetrations of oestradiol-17-β testosterone and testosterone/oestradiol ratio in dogs with neoplastic and degenerative testicular disease. Res Vet Sci 2002 73 267-272.

  • 21. Nielsen S.W. Lein D.H.: Tumours of the testis. Bull World Health Organ 1974 50 71-78.

  • 22. Nowak M. Madej J.A.: Manifestation of tumours in domestic animals in Lower Silesia in 2000-2004. Medycyna Wet 2006 62 900-904.

  • 23. Nowak M. Madej J.A. Ciaputa R. Poradowski D.: Manifestation of tumours in domestic animals in Lower Silesia in 2005- 2008. Bull Vet Inst Pulawy 2010 54 229-236.

  • 24. Peters M.A. de Rooij D.G. Teerds K.J. van de Gaag I. van Sluijs F.J.: Spermatogenesis and testicular tumours in ageing dogs. J Reprod Fertil Suppl 2001 57 419-421.

  • 25. Peters M.A. Teerds K.J. van de Gaag I. de Rooij D.G. van Sluijs F.J.: Use of antibodies against LH receptor 3β-hydroxysteroid dehydrogenase and vimentin to characterize different types of testicular tumour in dogs. Reproduction 2001 121 287-296.

  • 26. Restucci B. Maiolino P. Paciello O. Martano M. De Vico G. Papparella S.: Evaluation of angiogenesis in canine seminomas by quantitative immunohistochemistry. J Comp Pathol 2003 128 252-259.

  • 27. Reuter V. E.: Origins and molecular biology of testicular germ cell tumors. Mod Pathol 2005 18 51-60.

  • 28. Romagnoli S.E.: Canine cryptorchidism. Vet Clin North Am Small Anim Pract 1991 21 533-544.

  • 29. Sanpera N. Masot N. Janer M. Romeo C. De Pedro R.: Oestrogen-induced bone marrow aplasia in a dog with Sertoli cell tumour. J Small Anim Pract 2002 43 365-369.

  • 30. Sapierzyński R.: Neoplasms of the urinary and genital system in dogs and cats. Part II. Tumors of testes prostate penis and prepuce. Życie Wet 2006 81 805- 811

  • 31. Scudamore C.L. Meredith A.L.: Sertoli cell tumour in an Amur tiger. J Comp Pathol 2001 124 78-82.

  • 32. Takiguchi M. Iida T. Kudo T. Hashimoto A.: Malignant seminoma with systemic metastases in a dog. J Small Anim Pract 2001 42 360-362.

  • 33. Taniyama H. Hirayama K. Nakada K. Numagami K. Yaosaka N. Kagawa Y. Izumisawa Y. Nakade T. Tanaka Y. Watanabe G. Taya K.: Immunohistochemical detection of inhibin-α-β B and -β A chains and 3β-hydroxysteroid dehydrogenase in canine testicular tumors and normal testes. Vet Pathol 2001 38 661-666.

  • 34. Thonneau P.F. Candia P. Mieusset R.: Cryptorchidism: incidence risk factors and potential role of environment. J Androl 2003 24 155-162.

  • 35. Weaver D.M. Tyler J.W. Miller M.A. Shore M.D. Cowart R.P.: Bilateral testicular interstitial cell tumour in a aged boar. Vet Rec 2000 146 224.

Journal information
Impact Factor

IMPACT FACTOR 2018: 0,829
5-year IMPACT FACTOR: 0,938

CiteScore 2018: 0.68

SCImago Journal Rank (SJR) 2018: 0.291
Source Normalized Impact per Paper (SNIP) 2018: 0.501

Cited By
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 645 355 26
PDF Downloads 335 189 20