Nanostructured bone-like scaffolds for restoration of trabecular bone remodeling capability
This paper presents the theoretical study about carbon nanotube substrates for tissue engineering and its applications. Because the replacement of bone tissue with artificial tissue can violate the remodeling process completely, the artificial material should not only consist of the same material properties, but also exhibit other characteristics which are equally important and need to be taken into consideration. These are above all the mechanosensation. Besides replacing natural tissue, the nanostructured scaffolds presented in the paper can help the tissue growth by stimulating this process. The developed trabecular bone remodeling simulation method responsible for the nanostructured scaffold behavior is implemented here. Thus, the nanostructured bone-like scaffolds reflect the remodeling capability of the biological system, not only due to their application as replacement of natural tissue, but also due to their effects in the field of mechanosensation.
R. Huiskes, R. Ruimerman, G.H. van Lenthe, and J.D. Janssen, "Effects of mechanical forces on maintenance and adaptation of form in trabecular bone", Nature 404, 704-706 (2000).
J. Wolff, Das Gesetz der Transformation der Knochen, Hirschwald, Berlin, 1892.
T. Adachi and Y. Tomita, "Functional adaptation of cancellous bone in human proximal femur predicted by trabecular surface remodeling simulation toward uniform stress state", J. Biomech. 35, 1541-1551 (2002).
G.L. Niebur, M.J. Feldstein, J.C. Yuen, T.J. Chen, and T.M. Keaveny, "High resolution finite element models with tissue strength asymmetry accurately predict failure of trabecular bone", J. Biomech. 33, 1575-1583 (2000).
J.H. Waarsing, J.S. Day, and H. Weinans, "An improved segmentation method for in vivo CT imaging", J. Bone and Mineral Research 19 (10), 1640-1650 (2004).
R. Ruimerman, B. Van Rietbergen, P. Hilbers, and R. Huiskes, "A 3-dimensional computer model to simulate trabecular bone metabolism", Biorheology 40, 315-320 (2003).
M. Nowak, "A generic 3-dimensional system to mimic trabecular bone surface adaptation", Computer Methods in Biomechanics and Biomechanical Engineering 9 (5), 313-317 (2006).
M.A. Correa-Duarte, N. Wagner, J. Rojas-Chapana, C. Morsczeck, M. Thie, and M. Giersig, "Fabrication and biocompatibility of carbon nanotube-based 3D networks as scaffolds for cell seeding and growth", Nano Lett. 4 (11), 2233-2236 (2004).
I. Firkowska, M. Olek, N. Pazos-Peréz, J. Rojas-Chapana, and M. Giersig, "Highly ordered MWNT-based matrices: topography at the nanoscale conceived for tissue engineering", Langmuir 22, 12 (2006).
G. Szefer and D. Jasińska, "Modeling of strains and stresses of material nanostructures", Bull. Pol. Ac.: Tech. 57 (1), 41-46 (2009).
M. Nowak, "Structural optimization system based on trabecular bone surface adaptation", Struct Multidisc Optim 32, 241-249 (2006).
G. Ctistis, P. Patoka, X. Wang, K. Kempa, and M. Giersig, "Optical transmission through hexagonal arrays of subwavelength holes in thin metal films", Nano Lett. 7 (9), 2926-2930 (2007).