Background/Aim: The present analysis focuses on examining a case series of eight patients diagnosed with a granular cell tumor located in the oral cavity. Case series: The patients’ clinical states were thoroughly studied, along with the histopathological and immunohistochemical examinations findings. Their surgical treatment and postoperative course are also within the scope of this analysis. Numerous histogenesis theories and the appropriate tumor treatment are mentioned within the article being always in accordance with the relative literature. Conclusions: Oral granular cell tumor is a benign oral disease of possible neural origin commonly located on the tongue. Surgical excision is the treatment of choice. In any case, histological and immunohistochemical examination confirm both the clinical diagnosis and the differential diagnosis between oral squamous cell carcinoma.
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1. Collins BM Jones AC. Multiple granular cell tumors of the oral cavity: report of a case and review of the literature. J Oral Maxillofac Surg 1995;53:707-711.
2. Gomes CC Fonseca-Silva T Gomez RS. Evidence for loss of heterozygosity (LOH) at chromosomes 9p and 17p in oral granular cell tumors: a pilot study. Orl Surg Oral Med Oral Pathol Oral Radiol 2013;115:249-253.
3. Cole E Rahman N Webb R. Case series: two cases of an atypical presentation of oral granular cell tumour. Case Rep Med 2012;2012.
4. Gayen T Das A Shome K Bandyopadhyay D Das D Saha A. Granular cell tumor: An uncommon benign neoplasm. Indian J Dermatol 2015;60:322.
5. Suchitra G Tambekar KN Gopal KP. Abrikossoff’s tumor of tongue: Report of an uncommon lesion. J Oral Maxillofac Pathol 2014;18:134-136.
6. Suzuki S Uchida K Harada T Nibe K Yamashita M Ono K et al: The origin and role of autophagy in the formation of cytoplasmic granules in canine lingual granular cell tumors. Vet Pathol 2015;52:456-464.
7. Alotaibi O Al Sheddi M. Neurogenic tumors and tumorlike lesions of the oral and maxillofacial region: A clinicopathological study. Saudi Dent J 2016;28:76-79.
8. Kaiserling E Ruck PXiao JC Congenital epulis and granular cell tumor: a histologic and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;80:687-697.
9. Al-Eryani K Karasneh J Sedghizadeh PP Ram S Sawair F. Lack of Utility of Cytokeratins in Differentiating Pseudocarcinomatous Hyperplasia of Granular Cell Tumors from Oral Squamous Cell Carcinoma. Asian Pac J Cancer Prev 2015;17:1785-1787.
10. Kumar R Jaiswal S Singhal A Garg R. Congenital granular cell lesion: A rare tumor of new born. J Oral Maxillofac Pathol 2013;17:440-442.
11. Yıldırım C Zerener T Şençimen M Akgün ÖM Altuğ HA Çiçek AF. Congenital Gingival Granular Cell Tumor: A Case Report. J Dent (Shiraz) 2017;18:70-72.
12. Ferreira JC Oton-Leite AF Guidi R Mendonça EF. Granular cell tumor mimicking a squamous cell carcinoma of the tongue: a case report. BMC Res Notes 2017;10:14.