Treatment of Biphosphonate-Related Osteonecrosis of the Jaw (BRONJ) Combining Surgical Resection and PRGF-Endoret® and Rehabilitation with Dental Implants: Case Report

Open access

Summary

Background: The first cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ) were reported in 2003. Since then number of possible treatments have been proposed.

Case report: We report a case of a 50-year-old patient with bisphosphonate-related osteonecrosis of the jaw (BRONJ). The treatment included resection of necrotic bone and the application of plasma rich in growth factors (PRGF®-Endoret®). We closed the ulcer in the soft tissue and the treated bone was regenerated one year later. Finally the regenerated area was rehabilitated with dental implants.

Conclusion: Resection followed by PRGF® -Endoret® was successful in promoting closure of the wound and the recovery of nerve function.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 2003; 61:1115-1117.

  • 2. Novince CM Ward BB McCauley LK. Osteonecrosis of the jaw: an update and review of recommendations. Cell Tiss Organ 2009; 189:275-283.

  • 3. European Medicines Agency (EMEA). Committee for Medicinal Products for Human Use (CHMP). EMEA/CHMP assessment report on bisphosphonates and osteonecrosis of the jaw. EMEA/CHMP/291125/2009.

  • 4. Otto S Hafner S Grotz KA. The role of inferior alveolar nerve involvement in bisphosphonate-related osteonecrosis of the jaw. J Oral Maxillofac Surg 2009; 67:589-592.

  • 5. Yu W Wang J Yin J. Platelet-rich plasma: a promising product for treatment of peripheral nerve regeneration after nerve injury. Int J Neurosci 2011; 121:176-180.

  • 6. Anitua E Prado R Orive G. A lateral approach for sinus elevation using PRGF technology. Clin Implant Dent Relat Res 2009; 11:e23-e31.

  • 7. Freiberger JJ Feldmeier JJ. Evidence supporting the use of hyperbaric oxygen in the treatment of osteoradionecrosis of the jaw. J Oral Maxillofac Surg 2010; 68:1903-1906.

  • 8. Ruggiero SL Dodson TB Assael LA Landesberg R Marx RE Mehrotra B. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws—2009 update. J Oral Maxillofac Surg 2009; 67:2-12.

  • 9. Mozzati M Gallesio G Arata V Pol R Scoletta M. Platelet rich therapies in the treatment of intravenous bisphosphonate-related osteonecrosis of the jaw: a report of 32 cases. Oral Oncol 2012; 48:469-474.

  • 10. Mozzati M Arata V Gallesio G. Tooth extraction in patients on zoledronicacid therapy. Oral Oncol 2012; 48:817-821.

  • 11. Anitua E Zalduendo M Troya M Orive G. PRGF exerts a cytoprotective role in zoledronic acid-treated oral cells. Clin Oral Investig 2016;20 :513-521.

Search
Journal information
Metrics
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 584 397 24
PDF Downloads 145 117 0