Natural rubber latex is found in numerous medical and dental products. Adverse latex reactions in dental patients and practitioners have significantly increased since the introduction of universal precautions for infection control. These reactions range from contact dermatitis to potentially life-threatening hypersensitivity. Patients with a history of spina bifida, urogenital anomalies, multiple surgical procedures, allergic reactions or atopy, health care personnel and latex production workers are at increased risk of latex allergy. Diagnosis is based on a combination of clinical history and laboratory tests. Identification of latex sources and the avoidance of latex exposure are critical for protecting both dental patients and dental personnel.
1. Field EA, Fay MF. Issues of latex safety in dentistry. Br Dent J, 1995; 179:247.
2. Condemi JJ. Allergic reactions to natural rubber latex at home, to rubber products, and to cross reacting foods. J Allergy Clin Immunol, 2002; 110:107-110.
3. Hepner DL, Castells MC. Latex allergy: an update. Anesth Analg, 2003; 96:1219-1229.
4. Spina AM, Levine HJ. Latex allergy: a review for the dental professional. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1999; 87:5-11.
5. Mehra P, Hunter MJ. Latex allergy: a review of considerations for the oral and maxillofacial surgeon. J Oral Maxillofac Surg, 1998; 56:1426-1430.
6. Dyck RJ. Historical development of latex allergy. AORN J, 2000 Jul; 72:27-99, 32-33, 35-40.
7. Ownby DR. A history of latex allergy. J Allergy Clin Immunol, 2002; 110:27-32.
8. Field EA. The use of powdered gloves in dental practice: a cause for concern? J Dent, 1997; 25:209-214.
9. Kean T, McNally M. Latex hypersensitivity: a closer look at considerations for dentistry. J Can Dent Assoc, 2009; 75:279-282.
10. Hamann CP, Rodgers PA, Sullivan K. Management of dental patients with allergies to natural rubber latex. Gen Dent, 2002; 50:526-536.
11. Yeang HY, Arif SA, Yusof F, Sunderasan E. Allergenic proteins of natural rubber latex. Methods, 2002; 27:32-45.
12. Shoup AJ. Guidelines for the management of latex allergies and safe use of latex in perioperative practice settings. AORN J, 1997; 66:726, 729-731.
13. Field EA, King CK. Skin problems associated with routine wearing of protective gloves in dental practice. Br Dent J, 1990; 168:281-285.
14. Ahmed DD, Sobczak SC, Yunginger JW. Occupational allergies caused by latex. Immunology Allergy Clin North Am, 2003; 23:205-219.
15. Hudson ME. Dental surgery in pediatric patients with spina bifida and latex allergy. AORN J, 2001; 74:57-63.
16. Woods JA, Lambert S, Platts-Mills TA, Drake DB, Edlich RF. Natural rubber latex allergy: spectrum, diagnostic approach, and therapy. J Emerg Med, 1997; 15:71-85.
17. Ellsworth PI, Merguerian PA, Klein RB, et al. Evaluation and risk factors of latex allergy in spina bifida patients: is it preventable? J Urol, 1993; 150:691-693.
18. Banta JV, Bonanni C, Prebluda J. Latex anaphylaxis during spinal surgery in children with myelomeningocele. Dev Med Child Neurol, 1993; 35:540-548.
19. Slater JE. Allergic reactions to natural rubber. Ann Allergy, 1992; 68:203.
20. Bowyer RV. Latex allergy: how to identify it and the people at risk. J Allergy Clin Nurs, 1999; 8:144-149.
21. Kelly KJ, Kurup VP, Reijula KE, Fink JN. The diagnosis of natural rubber latex allergy. J Allergy Clin Immunol, 1994; 93:813-816.
22. Moneret-Vautrin DA, Beaudouin E, Widmer S, Moutan C, Kanny G, Prestat F, et al. Prospective study of risk factors in natural rubber latex hypersensitivity. Dev Med Child Neurol, 1993; 35:540-548.
23. Mota Biaggio AN, Turrini RNT. Perioperative latex hypersensitivity reactions: an integrative literature review. Rev Latino-Am Enfermagem, 2012; 20:411-420.
24. Field EA. Dental surgeons with natural rubber latex allergy: a report of 20 cases. Occup Med, 1999; 49:103-107.
25. Saary MJ, Kanani A, Alghadeer H, Holness DL, Tarlo SM. Changes in rates of natural rubber latex sensitivity among dental school students and staff members after changes in latex gloves. J Allergy Clin Immunol, 2002; 109:131-135.
26. Hamann CP, DePaola LG, Rodgers PA. Occupation-related allergies in dentistry. J Am Dent Assoc, 2005; 136:500-510.
27. Allmers H, Schmengler J, Skudlik C. Primary prevention of natural rubber latex allergy in the German health care system through education and intervention. J Allergy Clin Immunol, 2002; 110:318-323.
28. Arellano R, Bradley J, Sussman G. Prevalence of latex sensitization among hospital physicians occupationally exposed to latex gloves. Anesthesiology, 1992; 77:905-908.
29. Turjanmaa K. Incidence of immediate allergy to latex gloves in hospital personnel. Contact Dermatitis, 1987; 17:270-275.
30. Kelly KJ, Kurup V, Zacharisen M, Resnick A, Fink JN. Skin and serologic testing in the diagnosis of latex allergy. J Allergy Clin Immunol, 1993; 91:1140-1145.
31. Azofra García J. J Investig Allergol Clin Immunol, 2007; 17:164-167.
32. Marsh DG, Hsu SH, Hussain R, et al. Genetics of human response to allergens. J AIlergy Clin Immun, 1980; 65:322-332. Shield S, Blaiss M. Prevalence of latex sensitivity in children evaluated for inhalant allergy. Allergy Proc, 1992; 13:129-130.
33. Turjanmaa K, Kanto M, Kautiainen H, Reunala T, Palosuo T. Long-term outcome of 160 adult patients with natural rubber latex allergy. J Allergy Clin Immunol, 2002; 110:70-74.
34. Tarlo SM, Wong L, Roos J, Booth N. Occupational asthma caused by latex in a surgical glove manufacturing plant. J Allergy Clin Immunol, 1990; 85:626-631.
35. Hamann C, Turjanmaa K, Rietschel R, Siew C, Owensby D, Gruninger S, et al. Natural rubber latex hypersensitivity: incidence and prevalence of type I allergy in the dental professional. J Am Dent Assoc, 1998; 129:43-54.
36. Fonacier S, Dreskin S, Leung D. Allergic skin diseases. J Allergy Clin Immunol, 2010; 125:138-149.
37. Mota Biaggio AN, Turrini RNT. Perioperative latex hypersensitivity reactions: an integrative literature review. Rev Latino-Am Enfermagem, 2012; 20:411-420.
38. Beezhold D, Beck WP. Surgical glove powders bind latex antigens. Archs Surg, 1992; 127:1354-1357.
39. Mozzanica N. Pathogenetic aspects of allergic and irritant contact dermatitis. Clin Dermatol, 1992; 10:115-121.
40. Mathias CG, Maibach HI. Dermatotoxicology monographs I. Cutaneous irritation: Factors influencing the response to irritants. Clin Toxicol, 1978; 13:333-346.
41. Rietschel RL. Mechanisms in irritant contact dermatitis. Clin Dermatol, 1997; 15:557-559.
42. Heese A, van Hintzenstern J, Peters KP, Koch HU, Hornstein OP. Allergic and irritant reactions to rubber gloves in medical health services. J Am Acad Dermat, 1991; 25:831-839.
43. Bergstresser PR. Contact allergic dermatitis, old problem and new techniques. Arch Dermatol, 1989; 125:276-279.
44. Turjanmaa K, Reunala T, Alenius H, et al. Allergens in latex surgical glove and glove powder. Lancet, 1990; 336:1588.
45. Shojaei AR, Haas DA. Local anesthetic cartridges and latex allergy: a literature review. J Can Dent Assoc, 2002; 68:622-626.
46. Charous BL, Tarlo SM, Charous MA, Kelly K. Natural rubber latex allergy in the occupational setting. Methods, 2002; 27:15-21.
47. Roy A, Epstein J, Onno E. Latex allergies in dentistry: recognition and recommendations. J Can Dent Assoc, 1997; 63:297-300.
48. Hamilton RG, Peterson EL, Ownby DR. Clinical and laboratory-based methods in the diagnosis of natural rubber latex allergy. J Allergy Clin Immunol, 2002; 110:47-56.
49. Hamilton RG. Diagnosis of natural rubber latex allergy. Methods, 2002; 27:22-31.
50. Meade BJ, Weissman DN, Beezhold DH. Latex allergy: past and present. Int Immunopharmacol, 2002; 2:225-238.
51. Yunginger JW, Jones RT, Fransway AF, Kelso JM, Warner MA, Hunt LW. J Allergy Clin Immunol, 1994; 93:836-842.
52. Charous BL, Schuenemann PJ, Swanson MC. Passive dispersion of latex aeroallergen in a healthcare facility. Ann Allergy Asthma Immunol, 2000; 85:285-290.
53. Hamann CP, Rodgers PA, Sullivan K. Allergic contact dermatitis in dental professionals: effective diagnosis and treatment. J Am Dent Assoc, 2003; 134:185-194.
54. Turjanmaa K, Reunala T, Rasanen L. Comparison of diagnostic methods in latex surgical glove contact urticaria. Contact Dermatitis, 1988; 19:241-247.
55. Kurup VP, Kelly KJ, Turjanmaa K, Zacharisen M, Resnick A. Immunoglobulin E reactivity to latex antigens in the sera of patients from Finland and the United States. J Allergy Clin Immunol, 1993; 91:1128-1134.
56. Burton AD. Latex allergy in health care workers. Occup Med, 1997; 12:609-626.
57. Nainar SM. Dental management of children with latex allergy. Int J Paediatr Dent, 2001; 11:322-326.
58. Nettis E, Colanardi MC, Ferrannini A, Tursi A. Reported latex allergy in dental patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2002; 93:144-148.
59. Clarke A. The provision of dental care for patients with natural rubber latex allergy: are patients able to obtain safe care? Br Dent J, 2004; 197:749-752.
60. Beezhold D, Beck WP. Surgical glove powders bind latex antigens. Archs Surg, 1992; 127:1354-1357.
61. Pandis N, Pandis B, Pandis V, Eliades T. Occupational hazards in orthodontics: a review of risks and associated pathology. Am J Orthod Dentof Orthop, 2007; 132:280-292.
62. Saary J, Tarlo SM, Kanani A, Holnes DL. Reduction in rates of latex sensitivity among dental students and staff after changes in latex gloves. Am J Respir Crit Care Med, 2001; 163:809.
63. Shoup AJ. Guidelines for the management of latex allergies and safe use of latex in perioperative practice settings. AORN J, 1997; 66:726, 729-731.
64. Liss GM, Sussman GL, Deal K, Brown S, Cividino M, Siu S, et al. Latex allergy: epidemiological study of 1351 hospital workers. Occup Environ Med, 1997; 54:335-342.
65. Kleier DJ, Shibilski K. Management of the latex hypersensitive patient in the endodontic office. J Endod, 1999; 25:825-828.
66. Heilman DK, Jones RT, Swanson MC, Yunginger JW. A prospective, controlled study showing that rubber gloves are the major contributor to latex aeroallergen levels in the operating room. J Allergy Clin Immunol, 1996; 98:325-330.
67. Knowles KI, Ibarrola JL, Ludlow MO, Anderson JR, Newcomb BE. Rubber latex allergy and the endodontic patient. J Endod, 1998; 24:760-762.
68. Huber MA, Terezhalmy GT. Adverse reactions to latex products: preventive and therapeutic strategies. J Contemp Dent Pract, 2006; 7:97-106.
69. Patterson CJW. Polydam-polythene sheet, a practice alternative to rubber dam for patients allergic to rubber compounds. Int Endod J, 1989; 22:252-253.
70. Kosti E, Lambrianidis T. Endodontic treatment in cases of allergic reaction to rubber dam. J Endod, 2002; 28:787-789.
71. Setlock MA, Cotter TP, Rosner D. Latex allergy: failure of prophylaxis to prevent severe reaction. Anesth Analg, 1993; 76:650-652.
72. Birmingham PK, Dsisa RM, Grayhack JJ, Han J, Wheeler M, Pongracic JA, et al. Do latex precautions in children with myelodysplasia reduce intra-operative allergic reactions? J Pediatr Orthop, 1996; 16:799-802.
73. Pumphrey RS, Duddridge M, Norton J. Fatal latex allergy. J Allergy Clin Immunol, 2001; 107:558.
74. Costa GE, Johnson JD, Hamilton RG. Cross-Reactivity studies of gutta-percha, gutta-balata, and natural rubber latex (Hevea brasiliensis). J Endod, 2001; 27:584-587.
75. Hamann C, Rodgers PA, Alenius H, Halsey JF, Sullivan K. Cross-reactivity between gutta-percha and natural rubber latex. J Am Dent Assoc, 2002; 133:1357-1367.
76. Kang PB, Vogt K, Gruninger SE, Marshall M, Siew C, Meyer DM. The immuno cross-reactivity of gutta percha points. Dent Mater, 2007; 23:380-384.
77. Gazelius B, Olgart L, Wrangsjo K. Unexpected symptoms to root filling with gutta-percha. A case report. Int Endod J, 1986; 19:202-204.
78. Boxer MB, Grammer LC, Orfan N. Gutta-percha allergy in a healthcare worker with latex allergy. J Allergy Clin Immunol, 1994; 93:943-944.
79. Toraason M, Sussman G, Biagini R, Meade J, Beezhold D, Germolec D. Latex allergy in the workplace. Toxicol Sci, 2000; 58:5-14.
80. Holness DL, Kudla I. Workers with occupational contact dermatitis: workplace characteristics and prevention practices. Occup Med (Lond), 2012; 62:455-457.