Pcl/Chitosan Blended Nanofibrous Tubes Made by Dual Syringe Electrospinning

Martin Hild 1 , Mohammed Fayez Al Rez 2 , Dilbar Aibibu 1 , Georgios Toskas 1 , Tong Cheng 1 , Ezzedine Laourine 1  and Chokri Cherif 1
  • 1 Institute of Textile Machinery and High Performance Material Technology, Technische Universität Dresden, Germany
  • 2 Biomedical Technology Department, Applied Medical Sciences College, King Saud University, Riyadh, Saudi Arabia

Abstract

3D tubular scaffolds made from Poly-(Ɛ-caprolactone) (PCL)/chitosan (CS) nanofibres are very promising candidate as vascular grafts in the field of tissue engineering. In this work, the fabrication of PCL/CS-blended nanofibrous tubes with small diameters by electrospinning from separate PCL and CS solutions is studied. The influence of different CS solutions (CS/polyethylene glycol (PEO)/glacial acetic acid (AcOH), CS/trifluoroacetic acid (TFA), CS/ AcOH) on fibre formation and producibility of nanofibrous tubes is investigated. Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) is used to verify the presence of CS in the blended samples. Tensile testing and pore size measurements are done to underline the good prerequisites of the fabricated blended PCL/ CS nanofibrous tubes as potential scaffolds for vascular grafts. Tubes fabricated from the combination of PCL and CS dissolved in AcOH possesses properties, which are favourable for future cell culture studies.

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