The role of selenium in nutrition – A review

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The role of selenium has been changed over the last decade. The element that was previously considered to be toxic turned out to be present in the human body in amounts of 10–15 mg, and almost every cell of our body contains it. Selenium contributes to growth, supports healthy muscle activity, reproductive organs, reduces the toxicity of certain elements such as mercury, supports the immune system, and even delays the spread of certain viruses (influenza, Ebola, HIV). Selenium-deficient areas of Europe could be a risk for their populations. The recommended daily intake (RDA) of selenium is 55 µg/day, while WHO and FAO have set up the daily tolerable dose at 400 µg/day. We must count with the harmful effects of selenium overdose, but it is almost impossible to introduce this amount into our body solely with food. Our selenium sources can be refilled with food supplements or selenium-enriched functional foods. In the review article, we report about the role of selenium in the environment, selenium-enriched plants, selenium-enriched yeast, the role of selenium in animal feed and in the human body, the opportunities of selenium restoration, selenium-enriched animal products, and the selenium content of milk.

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  • [1] C. B. Allan G. M. Lacourciere T. C. Stadtman Responsiveness of selenoproteins to dietary selenium. Annual Review of Nutrition 19. (1999) 1–16.

  • [2] C. Ani S. Grantham-McGregor D. Muller Nutritional supplementation in Down syndrome: Theoretical considerations and current status. Developmental Medicine & Child Neurology 42. (2007) 207–213.

  • [3] J. R. Arthur The role of selenium in thyroid hormone metabolism. Canadian Journal of Physiology and Pharmacology 69. (1991) 1648–1652.

  • [4] Y. C. Awashti E. Beutler K. Srivastava Purification and properties of human erythrocyte glutathione peroxidase. Journal of Biological Chemistry 250. (1975) 5144–5149.

  • [5] H. Bankhofer Bio-Selen Natürlicher Schutz für unser Immunsystem. Munich Herbig Verlagsbuchhandlung (1988).

  • [6] G. S. Bańuelos et al. Selenium accumulation distribution and speciation in spineless prickly pear cactus: A drought- and salt-tolerant selenium-enriched nutraceutical fruit crop for biofortified foods. Plant Physiology 155. (2011) 315–327.

  • [7] M. A. Beilstein P. D. Whanger Selenium containing proteins in higher primates. Journal of Nutrition 116. (1986) 706–712.

  • [8] M. A. Beilstein P. D. Whanger G. Q. Yang Chemical forms of selenium in corn and rice grown in a high selenium area of China. Biomedical and Environmental Sciences 4. (1991) 392–398.

  • [9] L. Bendhal B. Gammelgaard Separation and identification of Semethyl-seleno-galactosamine a new metabolite in basal human urine by HPLC-ICP-MS and CE-nano-ESI-(MS). Journal of Analytical Atomic Spectrometry 19. (2004) 950–957.

  • [10] J. Bokori et al. A takarmányozás alapjai. Budapest Mezőgazda Kiadó (2003).

  • [11] K. M. Brown J. R. Arthur Selenium selenoproteins and human health: A review. Public Health Nutrition 4. (2001) 593–599.

  • [12] M. P. Burke K. Opeskin Fulminant heart failure due to selenium deficiency cardiomyopathy (Keshan disease). Medicine Science and the Law 42. (2002) 10–13.

  • [13] L. Calamari F. Petrera F. Abeni G. Bertin Metabolic and hemato-logical profiles in heat stressed lactating dairy cows fed diets supplemented with different selenium sources and doses. Livestock Science 142. (2011) 128–137.

  • [14] L. Calamari F. Petrera G. Bertin Effects of either sodium selenite or Se yeast (Sc CNCM I-3060) supplementation on selenium status and milk characteristics in dairy cows. Livestock Science 128. (2010) 154–165.

  • [15] J. C. Chang Selenium content of Brazil nuts from two geographic locations in Brazil. Chemosphere 30. (1995) 801–802.

  • [16] J. P. Chanoine Selenium and thyroid function in infants children and adolescents. BioFactors 19. (2003) 137–143.

  • [17] C. C. Clayton C. A. Bauman Diet and azo dye tumors: effect of diet during a period when the dye is not fed. Cancer Research 9. (1949) 575–580.

  • [18] I. P. Clement. D. J. Lisk Efficacy of cancer prevention by high-selenium garlic is primarily dependent on the action of selenium. Carcinogenesis 16. (1995) 2649–2652.

  • [19] G. F. Combs: Selenium in global food systems. The British Journal of Nutrition 85. (2001) 517–547.

  • [20] J. E. Cone M. R. Del Rio J. N. Davis T. C. Stadtman Chemical characterization of the selenoprotein component of clostridial glycine reductase: identification of selenocysteine as the organoselenium moiety. Proceedings of the National Academy of Sciences of the United States of America 73. (1976) 2659–2663.

  • [21] P. J. Craig Organometallic compounds in the environment. Longman Group Ltd. London 1986. (1986) 255–277.

  • [22] J. Csapó Cs. Albert Funkcionális élelmiszerek. Debrecen Debreceni Egyetemi Kiadó (2018).

  • [23] J. Csapó Cs. Albert Zs. Csapóné Kiss Funkcionális élelmiszerek. Cluj-Napoca Scientia Kiadó (2016).

  • [24] J. Csapó Zs. Csapóné Kiss Tej és tejtermékek a táplálkozásban. Budapest Mezőgazda Kiadó (2002).

  • [25] M.Á. Cser I. Sziklai-László A szelén szerepe a humán medicinában. In: M.Á. Cser I. Sziklai-László (eds) A szelén szerepe a környezetben és egészségvédelemben. Budapest Frag Bt. (1998) 28–46.

  • [26] K. Dredge Selenium and animal health. Agrifood Research Reports 69. (2005) 51–53.

  • [27] B. M. Dworkin Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS). Chemico-Biological Interactions 91. (1994) 181–186.

  • [28] L. Ebdon L. Pitts R. Cornelis H. Crews O. F. X. Donard P. Quevauviller Trace element speciation for environment. London Royal Society of Chemistry (2001).

  • [29] D. R. Ellis D. E. Salt Plants selenium and human health. Current Opinion in Plant Biology 6. (2003) 273–279.

  • [30] P. Eszenyi A. Sztrik B. Babka J. Prokisch Elemental nano-sized (100–500 nm) selenium production by probiotic lactic acid bacteria. International Journal of Bioscience Biochemistry and Bioinformatics 1. (2011) 148.

  • [31] G. Feroci R. Badiello A. Fini Interactions between different selenium compounds and zinc cadmium and mercury. Journal of Trace Elements in Medicine and Biology 18. (2005) 227–234.

  • [32] J. W. Finley J. G. Penland Adequacy or deprivation of dietary selenium in healthy men: clinical and psychological findings. The Journal of Trace Elements in Experimental Medicine 11. (1998) 11–27.

  • [33] S. Florian S. Krehl M. Loewinger A. Kipp A. Banning S. Esworthy C. Fong-Fong R. Brigelius-Flohé Loss of GPx2 increases apoptosis mitosis and GPx1 expression in the intestine of mice. Free Radical Biology and Medicine 49. (2011) 1694–1702.

  • [34] T. E. Fox et al. Absorption of selenium from wheat garlic and cod intrinsically labelled with Se-77 and Se-82 stable isotopes. International Journal for Vitamin and Nutrition Research 75. (2005) 179–186.

  • [35] K. F. Gey Vitamins E plus C and interacting conutrients required for optimal health. A critical and constructive review of epidemiology and supplementation data regarding cardiovascular disease and cancer. Biofactors 7. (1998) 113–74.

  • [36] J. L. Gómez-Ariza D. Sanchez-Rodas E. Morales O. Herrgott I. L. Marr Inorganic and organic selenium compound speciation with coupled HPLC-MW-HG-AFS. Applied Organometallic Chemistry 13. (1999) 783–787.

  • [37] J. L. Gómez-Ariza J. A. Pozas I. Giraldez E. Morales Speciation of volatile forms of selenium and inorganic selenium in sediments by gas chromatography–mass spectrometry. Journal of Chromatography A 823. (1998) 259–277.

  • [38] F. Gondi G. Pantó J. Fehér G. Bogye G. Alfthan Selenium in Hungary. The rock-soil-human system. Biological Trace Element Research 35. (1992) 299–306.

  • [39] M. Hidiroglou D. J. Jenkins Teneur en sélénium du lait de vache dans le nord ontarien. Annales de Zootechnie (1975) 129–132.

  • [40] D. H. Holben A. M. Smith The diverse role of selenium within selenoproteins: A review. Journal of American Dietetic Association 99. (1999) 836–843.

  • [41] M. Horacsek A. LugasiÉ. Martos Az étrend-kiegészítok. Új Diéta 1. (2006) 8–9.

  • [42] Institute of Medicine Food and Nutrition Board. Dietary reference intakes: Vitamin C vitamin E selenium and carotenoids. National Academy Press Washington D.C. (2000).

  • [43] E. Karag I. Németh A. Ferke J. Hajdú S. Pintér A vörösvértest szelén és antagonista nyomelemek valamint a plazma antioxidánsok koncentrációja és összefüggése érettújszülöttek köldökzsinór vérében. In: M.Á. Cser I. Sziklai-László (eds) A szelén szerepe a környezetben és egészségvédelemben. Budapest Frag Bt. (1998) 112–114.

  • [44] J. D. Keyes Salt which color is right? All Current Publications 87. (2012) 1–3.

  • [45] Y. Kobayashi Y. Ogra K. Ishiwata H. Takayama N. Aimi K. T. Suzuki Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range. Proceedings of the National Academy of Sciences of the United States of America 99. (2002) 15932–15936.

  • [46] M. Kotrebai M. Birringer J. F. Tyson E. Block P. C. Uden Selenium speciation in enriched and natural samples by HPLC-ICP-MS and HPLC-ESI-MS with perfluorinated carboxylic acid ion-pairing agents. Analyst 125. (2000) 71–78.

  • [47] M. K. McGuire et al. Selenium status of infants is influenced by supplementation of formula or maternal diets. American Journal of Clinical Nutrition 58. (1993) 643–648.

  • [48] S. McSheehy W. Yang F. Pannier J. Szpunar R. Lobinski J. Auger M. Potin-Gautier Speciation analysis of selenium in garlic by two-dimensional high-performance liquid chromatography with parallel inductively coupled plasma mass spectrometric and electrospray tandem mass spectrometric detection. Analytica Chimica Acta 421. (2000) 147–153.

  • [49] A. Meister M. Anderson Glutathione. Annual Review of Biochemistry 52. (1983) 711–760.

  • [50] B. Michalke H. Witte P. Schramel Developments of a rugged method for selenium speciation. Journal of Analytical Atomic Spectrometry 16. (2001) 593–597.

  • [51] J. R. Mitchell W. L. Nelson W. Z. Potter H. A. Sasame D. J. Jollow Metabolic activation of furosemide to a chemically reactive hepatotoxic metabolite. Journal of Pharmacology and Experimental Therapeutics 199. (1976) 41–52.

  • [52] J. Molnár A szelén antioxidáns hatásai és a szelénellátottság kérdései. Orvosi Hetilap 154. (2013) 1613–1319.

  • [53] D. Mustacich G. Powis Thioredoxin reductase. Biochemical Journal 346. (2000) 1–8.

  • [54] A. A. Nelson O. G. Fitzhugh H. O. Calvery: Liver tumors following cirrhosis caused by selenium in rats. Cancer Reserach 3. (1943) 230–236.

  • [55] O. E. Olson: Selenium toxicity in animals with emphasis on man. Journal of the American College of Toxicology 5. (1986) 45–70.

  • [56] A. Polatajko M. Mihaly Dernovics R. Ruzik J. R. Encinar J. Szpunar A systematic approach to selenium speciation in selenized yeast. Journal of Analytical Atomic Spectrometry 19. (2004) 114–120.

  • [57] C. Reilly Selenium: A new entrant into the functional food arena. Trends in Food Science & Technology 9. (1998) 114–118.

  • [58] J. Rigó Dietetika. Medicina Könyvkiadó Rt. Budapest. 71. (2002) 113–117.

  • [59] J. T. Rotruck A. L. Pope H. E. Ganther A. B. Swanson D. G. Hafeman W. G. Hoekstra Selenium. Biochemical role as a components of glutation peroxidase. Science 179. (1973) 588–590.

  • [60] A. W. Sampson Range and pasture management. John Wiley and Sons New York NY. (1923).

  • [61] G. N. Schrauzer Anticarcinogenic effects of selenium. Cellular and Molecular Life Sciences 57. (2000) 1864–1873.

  • [62] K. Schwarz C. M. Foltz Selenium as an integral part of factor-3 against dietary necrotic liver degeneration. Journal of American Chemical Society 79. (1957) 3292–3296.

  • [63] R. J. Shamberger G. Rudolph Protection against cocarcinogenesis by antioxidants. Experientia 22. (1966) 116.

  • [64] C. P. Skinner Environmental chemistry of selenium. Soil Science Society of America Journal 164. (1999) 70–72.

  • [65] J. Stone A. Doube D. Dudson J. Wallace Inadequate calcium folic acid vitamin E zinc and selenium intake in rheumatoid arthritis patients: Results of a dietary survey. Semin Arthritis Rheum. 27. (1997) 180–185.

  • [66] P. Surai Selenium in nutrition and health. Nottingham Nottingham University Press (2006).

  • [67] K. T. Suzuki Y. Ogra Metabolic pathway for selenium in the body: speciation by HPLC-ICP MS with enriched Se. Food Additives and Contaminants 19. (2002) 974–983.

  • [68]É. SzélesÁ. Tóth A. Nagy J. Prokisch B. Kovács Z. Gyori A szelén jelentosége az élővilágban és a kutatásban. Acta Agraria Debreceniensis 26. (2007) 278–286.

  • [69] L. Tamás A szelén betegségmegelőző szerepe. Komplementer Medicina 4. (2000) 16–20.

  • [70] M. Tamás J. Csapó Examination of the selenium content of wheat grasses produced in different soil types in Csík Basin. Acta Universitas Sapientiae Alimentaria 8. (2015) 30–44.

  • [71] N. Terry A. M. Zayed M. P. Desouza A. S. Tarun Selenium in higher plants. The Annual Review of Plant Physiology and Plant Molecular Biology 51. (2000) 401–432.

  • [72] Y. Thomassen E Nieboer Speciation of elements; trace elements in human health. Royal Society of Chemistry (1995).

  • [73] C. D. Thomson Assessment of requirements for selenium and adequacy of selenium status: A review. European Journal of Clinical Nutrition 58. (2004) 391–402.

  • [74] C. D. Thomson Selenium and iodine intakes and status in New Zealand and Australia. British Journal of Nutrition 91. (2004) 661–672.

  • [75] D. C. Turner T. C. Stadtman Purification of protein components of the clostridial glycine reductase system and characterization of protein A as a selenoprotein. Archives of Biochemistry and Biophysics 154. (1973) 366–381.

  • [76]É. Ungvári Nanopartikuláris szelénkészítmények farmakológiai vizsgálata–új lehetőségek a szelénpótlás területén. Debreceni Egyetem Gyógyszerészeti Tudományok Iskola Debrecen (2015) 17–22.

  • [77] P. Varo G. Alfthan P. Ekholm A. Aro P. Koivistoinen Selenium intake and serum selenium in Finland-effects of soil fertilization with selenium. American Journal of Clinical Nutrition 48. (1988) 324–329.

  • [78] L. N. Vernie Selenium in carcinogenesis. Biochimica et Biophysica Acta (BBA) – Reviews on Cancer 738. (1984) 203–217.

  • [79] G. P. Walker F. R. Dunshea J. W. Heard C. R. Stockdale P. T. Doyle Output of selenium in milk urine and feces is proportional to selenium intake in dairy cows fed a total mixed ration supplemented with selenium yeast. Journal of Dairy Science 93. (2010) 4644–4650.

  • [80] B. S. Weeks M. S. Hanna D. Cooperstein Dietary selenium and seleno-protein function. Medical Science Monitor 18. (2012) RA127–RA132.

  • [81] A. C. Wilson H. J. Thompson P. J. Schedin N. W. Gibson H. E Gauther Effect of methylated forms of selenium on cell viability and the induction of DNA strand breakage. Biochemistry and Pharmacology 43. (1992) 1137–1141.

  • [82] J. L. Zhang J. L. Li X. D. Huang S. Bo W. Rihua S. Li S. W. Xu Dietary selenium regulation of transcript abundance of selenoprotein N and selenoprotein W in chicken muscle tissues. Biometals 25. (2012) 297–307.

  • [83] 152/2009. (XI. 12.) FVM rendelet. Magyar Közlöny 159. (2009) 39554 p.

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