The essentiality of selenium for humans, animals, and plants, and the role of selenium in plant metabolism and physiology

  • 1 University of Debrecen, HU-4032, Debrecen, Hungary


After its discovery, selenium was most noted for its harmful effects. Selenium was the first element identified to occur in native vegetation at levels toxic to animals. Poisoning of animals can occur through consumption of plants containing toxic levels of selenium. Livestock consuming excessive amounts of selenized forages are afflicted with “alkali disease” and “blind staggers”. Typical symptoms of these diseases include loss of hair, deformed hooves, blindness, colic, diarrhoea, lethargy, increased heart and respiration rates, and eventually death. On the other hand, selenium deficiency in animal feeds can cause “white muscle disease”, a degenerative disease of the cardiac and skeletal muscles. In this regard, this review paper attempts to summarize the essentiality of selenium for humans, animals, and plants and the role of selenium in plant metabolism and physiology.

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  • [1] K. Schwarz, C. M. Foltz, Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. Journal of American Chemistry Society, 70. (1957) 3292–3293.

  • [2] D. A. Kopsell, D. E. Kopsell, Selenium. Chapter 18. In: A. V. Barker, D. J. Plibeam (eds), Handbook of plant nutrition. CRC Press. (2007) 515–549.

  • [3] E. A. H. Pilon-Smits, C. F. Quinn, W. Tapken, M. Malagoli, M. Schiavon, Physiological functions of beneficial elements. Current Opinion in Plant Biology, 12. (2009) 267–274.

  • [4] H. Hartikainen, Biogeochemistry of selenium and its impact on food chain quality and human health. Journal of Trace Elements in Medicine and Biology, 18. (2005) 309–318.

  • [5] A. F. El Mehdawi, J. J. Cappa, S. C. Fakra, J. Self, E. A. H. Pilon-Smits, Interactions of selenium hyperaccumulators and nonaccumulators during cocultivation on seleniferous or nonseleniferous soil – the importance of having good neighbors. New Phytologist, 194. (2012) 264–277.

  • [6] H. El-Ramady, T. Alshaal, É. Domokos-Szabolcsy, T. Shalaby, Y. Bayoumi, N. Elhawat, A. Sztrik, J. Prokisch, M. Fári, Selenium and its role in higher plants. In: E. Lichtfouse (ed.), Environmental chemistry for a sustainable world 6. Springer, Berlin. (2014b).

  • [7] L. F. De Filippis, Biochemical and molecular aspects in phytore-mediation of selenium. In: M. Ashraf, M. Ozturk, M. S. A. Ahmad (eds), Plant adaptation and phytoremediation, Springer, Dordrecht/Heidelberg/London/New York. (2010).

  • [8] T. C. Broyer, C. M. Johnson, R. P. Hudson, Selenium and nutrition of Astragalus I: Effects of selenite or selenate supply on growth and selenium content. Plant and Soil, 36. (1972) 635–649.

  • [9] T. C. Stadtman, Selenium biochemistry known as Se. Annual Review of Biochemistry, 59. (1990) 111–128.

  • [10] T. C. Stadtman, Selenocysteine. Annual Review of Biochemistry, 65. (1996) 83–100.

  • [11] M. J. Axley, A. Boeck, T. C. Stadtman, Catalytic properties of an Escherichia coli format dehydrogenase mutant in which sulphur replaces selenium. Proceedings of the National Academy of Sciences, USA, 88. (1991) 8450–8454.

  • [12] C. Reilly, Selenium in food and health. 2nd ed. Springer, Berlin. (2006).

  • [13] D. R. Ellis, D. E. Salt, Plants, selenium and human health. Current Opinion in Plant Biology, 6. (2003) 273–279.

  • [14] S. C. Low, M. J. Berry, Knowing when not to stop: selenocysteine incorporation in eukaryotes. Trends in Biochemical Sciences, 21. (1996) 203–208.

  • [15] L. H. Fu, X. F. Wang, Y. Eyal, Y. M. She, L. J. Donald, K. G. Standing, G. Ben-Hayyim, A seleno protein in the plant kingdom. The Journal of Biological Chemistry, 277. (2002) 25983–25991.

  • [16] A. K. Shanker, Countering UV-B stress in plants: does selenium have a role? Plant and Soil, 282. (2006) 21–26.

  • [17] S. J. Hamilton, Review of selenium toxicity in the aquatic food chain. Science of the Total Environment, 326. (2004) 1–31.

  • [18] G. F. Combs, S. B. Combs, The role of selenium in nutrition. Academic Press, Orlando. (1986).

  • [19] M. Germ, V. Stibilj, I. Kreft, Metabolic importance of selenium for plants. European Journal of Plant Science and Biotechnology, 1. (2007) 91–97.

  • [20] E. A. H. Pilon-Smits, Selenium in plants. In: U. Luettge, W. Beyschlag (eds), Progress in botany 76, Springer International Publishing, Cham. (2015) 93–107.

  • [21] A. L. Moxon, O. E. Olson, Selenium in agriculture. In: Selenium. Van Nostrand, New York, (1974) 675.

  • [22] E. Kabata-Pendias, Trace elements in soils and plants. 4th ed. CRC Press Taylor & Francis, Boca Raton. (2011).

  • [23] M. Hasanuzzaman, M. A. Hossain, F. Masayuki, Selenium in higher plants: physiological role, antioxidant metabolism and abiotic stress tolerance. Journal of Plant Science, 5. (2010) 354–375.

  • [24] R. Hajiboland, Effect of micronutrient deficiencies on plants, stress responses. In: P. Ahmad, M. N. V. Prasad (eds), Abiotic stress responses in plants: metabolism, productivity and sustainability. Springer, Berlin. (2012) 283–329.

  • [25] H. El-Ramady, É. Domokos-Szabolcsy, N. Abdalla, T. Alshaal, T. Shalaby, A. Sztrik, J. Prokisch, M. Fári, Selenium and nano-selenium in agroecosystems. Environmental Chemistry Letter, 12. (2014) 495–510.

  • [26] K. Pyrzynska, Solid phase extraction for preconcentration and separation of selenium. Solvent Extraction Ion Exchange, 13. (1995) 369–389.

  • [27] I. Djujic, O. Jozanov-Stankov, M. Milovac, O. Bosnic, V. Djermanovic, The impact of consuming wheat naturally enriched with selenium on trace elements and antioxidant defense in humans. 3rd International symposium on trace elements in human, New Perspec, Athens (2001). 281–304.

  • [28] M. Singh, H. Singh, D. K. Bhandari, Interaction of selenium and sulphur on the growth and chemical composition of raya. Soil Science, 129. (1980) 238–244.

  • [29] H. Hartikainen, P. Ekholm, V. Piironen, T. Xue, T. Koivu, M. Yli-Halla, Quality of the ryegrass and lettuce yields as affected by selenium fertilization. Agricultural and Food Science Finl., 6. (1997) 381–387.

  • [30] K. M. Carvalho, M. T. Gallardo-Williams, R. F. Benson, D. F. Martin, Effects of selenium supplementation on four agricultural crops. Journal of Agricultural and Food Chemistry, 51.(2003) 704–709.

  • [31] C. C. Chen, J. M. Sung, Priming bitter gourd seeds with selenium solution enhances germinability and antioxidative responses under suboptimal temperature. Physiologia Plantarum, 111. (2001) 9–16.

  • [32] N. Terry, A. M. Zayed, M. P. de Souza, A. S. Tarun, Selenium in higher plants. Annual Review of Plant Physiology and Plant Molecular Biology, 51. (2000) 401–432.

  • [33] P. J. White, H. C. Bowen, P. Parmaguru, M. Fritz, W. P. Spracklen, R. E. Spiby, M. C. Meacham, A. Mead, M. Harriman, L. J. Trueman, B. M. Smith, B. Thomas, M. R. Broadley, Interactions between selenium and sulphur nutrition in Arabidopsis thaliana. Journal of Experimental Botany, 55. (2004) 1927–1937.

  • [34] N. Rani, K. S. Dhillo, S. K. Dhillon, Critical levels of selenium in different crops grown in an alkaline silty loam soil treated with selenite-Se. Plant and Soil, 277. (2005) 367–374.

  • [35] S. M. Lyi, L. I. Heller, M. Rutzke, R. M. Welch, L. V. Kochian, L. Li, Molecular and biochemical characterization of the selenocysteine Se-methyltranferase gene and Se-methylselenocysteine synthesis in broccoli. Plant Physiology, 138. (2005) 409–420.

  • [36] A. M. Zayed, C. M. Lytle, N. Terry, Accumulation and volatilization of different chemical species of selenium by plants. Planta, 206. (1998) 284–289.

  • [37] M. Turakainen, Selenium and its effects on growth, yield and tuber quality in potato. University of Helsinki, Helsinki. (2007).

  • [38] Q. X. Hu, J. U. G. Pang, Effect of selenium on the yield and quality of green tea leaves harvested in early spring, (2003).

  • [39] P. Smrkolj, M. Germ, I. Kreft, V. Stibilj, Respiratory potential and Se compounds in pea (Pisumsativum L.) plants grown from Se-enriched seeds. Journal of Experimental Botany, 57. (2006) 3595–3600.

  • [40] G. H. Lyons, J. C. R. Stangoulis, R. D. Graham, Tolerance of wheat (Triticum aestivum L.) to high soil and solution selenium levels. Plant and Soil, 270. (2005) 179–188.

  • [41] P. Cartes, L. Gianfera, M. L. Mora, Uptake of selenium and its antioxidative activity in ryegrass when applied a selenate and selenite forms. Plant and Soil, 276. (2005) 359–367.

  • [42] M. P. de Souza, D. Chu, M. Zhao, A. M. Zayed, S. E. Ruzin, D. Schichnes, N. Terry, Rhizosphere bacteria enhance selenium accumulation and volatilization by Indian mustard. Plant Physiology, 119. (1998) 565–574.

  • [43] D. Van Hoewyk, S. E. Abdel-Ghany, C. Cohu, S. Herbert, P. Kugrens, M. Pilon, E. A. H. Pilon-Smits, The Arabidopsis cysteine desulfurase CpNifS is essential for maturation of iron-sulphur cluster proteins, photosynthesis, and chloroplast development. Proceedings of the National Academy of Sciences, USA, 104. (2007) 5686–5691.

  • [44] B. Neuhierl, A. Böck, On the mechanism of selenium tolerance in selenium accumulating plants. Purification and characterization of a specific selenocysteine methyltransferase from cultured cells of Astragalusbisulcatus. European Journal of Biochemistry, 239. (1996) 235–238.

  • [45] O. A. Beath, C. S. Gilbert, H. F. Eppson, The use of indicator plants in locating seleniferous areas in the Western United States. I. General. American Journal of Botany, 26. (1939a) 257–269.

  • [46] O. A. Beath, C. S. Gilbert, H. F. Eppson, The use of indicator plants in locating seleniferous areas in the Western United States. II. Correlation studies by states. American Journal of Botany, 26. (1939b) 296–315.

  • [47] H. H. Ge, X. J. Cai, J. F. Tyson, P. C. Uden, E. R. Denover, E. Block, Identification of selenium species in selenium-enriched garlic, onion and broccoli using high-performance ion chromatography with inductively coupled plasma mass spectrometry detection. Analytical Communications, 33. (1996) 279–281.

  • [48] A. Lauchli, Selenium in plants: uptake, functions, and environmental toxicity. Botanica Acta, 106. (1993) 455–468.

  • [49] J. W. Anderson, Selenium interactions in sulphur metabolism. In: L. J. De Kok (ed.), Sulphur nutrition and assimilation in higher plants – regulatory, agricultural and environmental aspects. SPB Academic, The Netherlands. (1993) 49–60.

  • [50] C. F. Quinn, C. N. Prins, J. L. Freeman, A. M. Gross, L. J. Hantzis, R. J. B. Reynolds, S. Yang, P. A. Covey, G. S. Bañuelos, I. J. Pickering, E. A. H. Pilon-Smits, Selenium accumulation in flowers and its effects on pollination. New Phytologist, 192. (2011a) 727–737.

  • [51] C. F. Quinn, K. Wyant, A. L. Wangeline, J. Shulman, M. L. Galeas, J. R. Valdez, M. W. Paschke, E. A. H. Pilon-Smits, Enhanced decomposition of selenium hyperaccumulator litter in a seleniferous habitat – evidence for specialist decomposers. Plant and Soil, 341. (2011b) 51–61.

  • [52] J. L. Freeman, L. H. Zhang, M. A. Marcus, S. Fakra, S. P. McGrath, E. A. H. Pilon-Smits, Spatial imaging, speciation and quantification of selenium in the hyperaccumulator plants Astragalusbisulcatus and Stanleyapinnata. Plant Physiology, 142. (2006) 124–134.

  • [53] J. L. Freeman, M. Tamaoki, C. Stushnoff, C. F. Quinn, J. J. Cappa, J. Devonshire, S. Fakra, M. A. Marcus, S. McGrath, D. Van Hoewyk, E. A. H. Pilon-Smits, Molecular mechanisms of selenium tolerance and hyperaccumulation in Stanleyapinnata. Plant Physiology, 153. (2010) 1630–1652.

  • [54] D. Van Hoewyk, G. F. Garifullina, A. R. Ackley, S. E. Abdel-Ghany, M. A. Marcus, S. Fakra, K. Ishiyama, E. Inoue, M. Pilon, H. Takahashi, E. A. H. Pilon-Smits, Overexpression of AtCpNifS enhances selenium tolerance and accumulation in Arabidopsis. Plant Physiology, 139. (2005) 1518–1528.

  • [55] P. J. White, H. C. Bowen, B. Marshall, M. R. Broadley, Extraordinarily high leaf selenium to sulfur ratios define “Se-accumulator” plants. Annals of Botany, 100. (2007) 111–118.

  • [56] M. L. Galeas, L. H. Zhang, J. L. Freeman, M. Wegner, E. A. H. Pilon-Smits, Seasonal fluctuations of selenium and sulphur accumulation in selenium hyperaccumulators and related non-accumulators. New Phytologist, 173. (2007) 517–525.

  • [57] I. Rosenfeld, O. A. Beath, Selenium. Geobotany, biochemistry, toxicity and nutrition. Academic Press, New York. (1964).

  • [58] A. Shrift, Selenium compounds in nature and medicine. Metabolism of selenium by plants and microorganisms. In: D. L. Klayma, W. H. H. Gunther (eds), Organic selenium compounds: their chemistry and biology. Wiley Interscience, New York (1973) 763–814.


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