Transport and separation through bulk liquid membrane of some biologic active compounds

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Transport through liquid membranes of various chemical species is a viable method for different applications in analytical or technological domain. This paper presents the transport and separation results of two compounds of pharmaceutical importance: salicylic acid and aspirin, using bulk liquid membrane technique. We studied the effect of the feed source and receiving phase pH on the transport efficiency of the two compounds throught chloroform membrane. These results were correlated with speciation diagrams of salicylic acid and aspirin. The speciation diagrams shows that in these pH conditions, for aqueous phase of the membrane system, the two compounds are mostly undissociated form and therefore active for transport. In this system it can be achieve separation of the two compounds, salicylic acid and aspirin, using a suitable complexing agent in the feed source such as Fe3+. In this way salicylic acid forms an inactive complex structure for transport while aspirin crosses the membrane and it is recovered in a percentage of 80% in the receiving phase membrane system.

  • [1]. AC Nechifor, E. Ruse, G. Nechifor and B. Serban, Revista de Chimie, 53, 20-26 (2002), [2]. M. Shamsipur, M.H.Mashhadizadeh and G. Azimi, Separation and Purification Technology, 27,155-161 (2002), [3]. M. Ma, B. Chen, X. Luob, H. Tan, D. He, Q. Xie and S. Yao, Journal of Membrane Science,234,101-109 (2004)

  • [4]. W. Cichy, S. Schlosser and J. Szymanowski, Journal of Chemical Technology and Biotechnology, 80, 189-197 (2005)

  • [5]. I. Diaconu, E. Ruse, I. Zaharia and E. Eftimie Totu, „Membranary procedure for concentrating some phenolic compounds”, Proc. 27th EMS SS 2010 Trends in Membranology,14-19 Iunie, (2010), p. 81-86

  • [6]. I.Diaconu, I.Zaharia, E. Ruse, E. Eftimie Totu, G. Nechifor, Proc. 13th Aachener MembranKolloquium, 495-500 (2010)

  • [7]. I. Diaconu, I. Zaharia, E. Ruse and D. A. Radu, Revista de Chimie, (Bucharest), 63, 153-158 (2012)

  • [8]. A.M. Josceanu, E. Ruse, C. Luca and E. Cerbu, Materials Science and Engineering C, 18, 79-85 (2001)

  • [9]. S. Schlosser and E. Sabolova, Chem papers, 53, 403-411 (1999), [10]. S. Schlosser, R. Kertesz and J Martak, Separation and Purification Technology, 41, 237-266 (2005), [11]. L. Kim, A. Hamdi, A. D. Stancu, R. Souane, L. Mutihac and J. Vicens, Journal of Inclusion Phenomena and Macrocyclic Chemistry 66, 55 (2010), [12]. T. Kaghazchia, A. Kargaria, R. Yegania and A. Zareb , Desalination 190, 161 (2006)

  • [13]. T. Oshima, K. Inoue, S. Furusaki and M. Goto, Journal of Membrane Science, 217, 87 (2003)

  • [14]. C.J. Lee, H.J. Yeh, W.Y. Yang and C.R. Kan, Biotechnology and Bioengineering., 43, 309 (1994)

  • [15]. E. Diacu, M. Mutihac, E. Ruse and M. Ceausescu, Journal of Inclusion Phenomena and Macrocyclic Chemistry 71, 339 (2011)

  • [16]. A. Panaggio and C. Rhodes, Drug Development and Industrial Pharmacy,10, 637-641 (1984)

  • [17]. I. Zaharia , I. Diaconu and Gh. Nechifor, The pH role in the transport of active principles of drugs through agitated bulk liquid membrane - to be published

Ovidius University Annals of Chemistry

Analele Universitatii "Ovidius" Constanta - Seria Chimie

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