In this paper are presented the author’s researches on designing, dynamical and structural evaluation of a transmission for a wheelchair, intended to persons with locomotors disabilities. The kinematics of proposed transmission is analyzed in order to realize a proper synthesis and design of gears. A 3D model of the transmission and wheelchair are designed in Solid Works, and they will be used for the dynamic simulation of the wheelchair robotic system in Adams software. In Adams is analyzed wheelchair trajectory and dynamics for a combined trajectory: linear motion and steering. Dynamic parameters obtained from simulation are used to perform a finite element analysis of bevel and worm gears. Simulation results reveal the transmission dynamics parameters, emphasize the efficiency of the transmission and enable implementation of this design to a wheelchair model.