The Evolution of Biochemical Indices After Basal Cell Epithelioma Removal - Case Report

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The paper proposes new exposure data on etiopathogenesis basal cell epithelioma and present a clinical case investigated dermatoscopic, biochemically, treated surgically and guided to avoid relapses. The case presented is part of typical cases of pigmented basal cell carcinoma. Biochemical and haematological investigations performed one day before the excisional intervention (results 1) and 30 days (results 2) after the intervention: It is recommended to monitor biochemical investigations in which alterations were found, and ways for raising the immunological status.

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  • 1. Bradford P. T. (2009). Skin cancer in skin of color. Dermatology Nursing 21(4) 170-7 206; quiz 178. Retrieved from

  • 2. Aydin D. Hölmich L. R. & Jakobsen L. P. (2016). Metastatic basal cell carcinoma caused by carcinoma misdiagnosed as acne - case report and literature review. Clinical Case Reports 4(6) 601-4.

  • 3. Tilli C. M. L. J. Van Steensel M. A. M. Krekels G. A. M. Neumann H. A. M. & Ramaekers F. C. S. (2005). Molecular aetiology and pathogenesis of basal cell carcinoma. British Journal of Dermatology 152(6) 1108-1124.

  • 4. He Y.-Y. Council S. E. Feng L. & Chignell C. F. (2008). UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/ epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes. Cancer Research 68(10) 3752-8.

  • 5. Suda T. Takahashi T. Golstein P. & Nagata S. (1993). Molecular cloning and expression of the fas ligand a novel member of the tumor necrosis factor family. Cell 75(6) 1169-1178.

  • 6. Filipowicz E. Adegboyega P. Sanchez R. L. & Gatalica Z. (2002). Expression of CD95 (Fas) in sun-exposed human skin and cutaneous carcinomas. Cancer 94(3) 814-819.

  • 7. Ghanadan A. Abdollahi P. Rabet M. Naraghi Z. Abbasi M. A. Moslehi H. & Abbasi A. (2014). Different Anatomical Distribution of Basal Cell Carcinoma Subtypes in Iranian Population: Association between Site and Subtype. Annals of Dermatology 26(5) 559-63.

  • 8. Rossy K. M. Janusz C. A. & Schwartz R. A. (2005). Cryptic exposure to arsenic. Indian Journal of Dermatology Venereology and Leprology 71(4) 230-5.

  • 9. Leonard G. Tony H. Sergiu C. & Roşoiu N. (2016). Environment and gender influence the location of basal cell carcinoma. Academy of Romanian Scientists Annals Series on Biological Sciences 5(1) 64-72.

  • 10. Kricker A. Armstrong B.K. Goumas C. Litchfield M. Begg C.B. Hummer A.J. Marrett L.D. Theis B. Millikan R.C. Thomas N. Culver H.A. Gallagher R.P. Dwyer T. Rebbeck T.R. Kanetsky P.A. Busam K. From L. Mujumdar U. Zanetti R. & Berwick M. (2007). Ambient UV personal sun exposure and risk of multiple primary melanomas. Cancer Causes & Control 18(3) 295-304.

  • 11. Sun Y. Kojima C. Chignell C. Mason R. & Waalkes M. P. (2011). Arsenic transformation predisposes human skin keratinocytes to UVinduced DNA damage yet enhances their survival apparently by diminishing oxidant response. Toxicology and Applied Pharmacology 255(3) 242-250.

  • 12. Ichihashi M. Ueda M. Budiyanto A. Bito T. Oka M. Fukunaga M. Tsuru K. & Horikawa T. (2003). UV-induced skin damage. Toxicology 189(1-2) 21-39.

  • 13. Pi J. He Y. Bortner C. Huang J. Liu J. Zhou T. Qu W. North S.L. Kasprzak K.S. & Diwan B.A. (2005). Low level long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesis. International Journal of Cancer 116(1) 20-6.

  • 14. Brinzea A. Popescu R. Antohe M. Balaban M. Hodorogea A. Gosa R.-A. & Popescu C.M. (2016). Carcinogeneza generatã de expunerea la soare în cancerele de piele non-melanocitare carcinogenesis due to sunlight exposure in nonmelanoma skin cancer referate generale general reports. Dermatovenerologie 61(3). 201-12.

  • 15. Ramachandran S. Hoban P.R. Ichii-Jones F. Pleasants L. Ali-Osman F. Lear J.T. Smith A.G. Bowers B. Jones P.W. & Fryer A.A. (2000). Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours. Pharmacogenetics 10(6) 545-56. Retrieved from

  • 16. Vargas M. L. Abella C. & Hernandez J. (2001). Diazepam increases the hypothalamic-pituitaryadrenocortical (HPA) axis activity by a cyclic AMP-dependent mechanism. British Journal of Pharmacology 133(8) 1355-61.

  • 17. ACTH | Synevo. (n.d.). Retrieved April 29 2017 from

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