Ki-67 Expression In Hepatocellular Carcinoma Developed On A Liver Cirrhosis

Open access


Hepatocellular carcinoma is one of the most common cancers worldwide and a major cause of death in many countries. To evaluate the clinicopathological correlations of proliferative activity in patients with hepatocellular carcinoma, Ki-67 antigen expression was examined using immunohistochemical staining with monoclonal antibody MIB1. Consecutive 40 patients who had undergone surgical resection for the treatment of HCC from January 2005 to December 2009 were enrolled in our study. The study group comprised 32 men and 8 women ranging from 27 to 76 (mean age, 54.6 SD±11.7) years of age. Expression of Ki-67 was negative in 22.5% of the 40 cases and Ki-67 positive expression “+”, “++”, “+++” was found in 11, 7 and 13 cases of hepatocellular carcinoma respectively. There are no statistically significant differences of the Ki-67 mean between age, sex distribution, dimension of the tumors, pattern of the tumor and Edmondson -Steiner grading.

1. FERENCI P, FRIED M, LABRECQUE D, BRUIX J, SHERMAN M.: World Gastroenterology Organisation Guidelines and Publications Committee. Hepatocellular carcinoma (HCC): a global perspective. J Gastrointestin Liver Dis. 2010;19(3):311-317.

2. LIN GY, CHEN ZL, LU CM, LI Y, PING XJ, HUANG R.: Immunohistochemical stud y on p53, H-rasp21, c-erbB-2 protein and PCNA expression in HCC tissues of Han and minority ethnic patients. World J Gastroenterol. 2000; 6(2): 234- 238.

3. SCHMITT-GRAFF A, ERT ELT V, ALLGAIER HP, KOELBLE K.: Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival. Hepatology 2003; 38: 470-480

4. JUN CUI, BAO-WEI DONG, PING LIANG, XIAO-LING YU, DE-JIANG YU: Effect of c-myc, Ki-67, MMP-2 and VEGF expression on prognosis of hepatocellular carcinomapatients undergoing tumor resection, World J Gastroenterol 2004;10(10):1533-1536

5. D’ERRICO A, GRIGIONI WF, FIORENTINO M, BACCARINI P, GRAZI GL, MANCINI AM: Overexpression of p53 protein and Ki67 proliferative index in hepatocellular carcinoma: an immuno-histochemical study on 109 Italian patients. Pathol Int 1994, 44:682-687.

6. NAKANISHI K, SAKAMOTO M, YAMASAKI S, TODO S, HIROHASHI S: Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma. Cancer 2005, 103:307-312.

7. FARINATI F, CARDIN R, DERRICO A et al: Hepatocyte proliferative activity in chronic liver damage as assessed by the monoclonal antibody MIB1 Ki-67 in archival material: the role of etiology, disease activity, and iron and lipid peroxidation. Hepatology 23: 1468-1475, 1996.

8. SOYUER I., EKUNCU C., KAYA M., GEN Y.: Diagnostic Value of Ki-67LI in Hepatocellular Carcinoma Turk J Med Sci 33 (2003) 15-19.

ARS Medica Tomitana

The Journal of "Ovidius" University of Constanta

Journal Information


All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 148 148 24
PDF Downloads 37 37 8