Food-Borne Pathogens and Contaminants in Raw Milk – A Review

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Abstract

The aim of the present review is to highlight the threats to human health posed by consumption of milk and dairy products. The interest in drinking raw milk has been growing in some societies as many people believe it has health benefits. Raw milk is promoted as ‘health food’ despite the fact that it poses a realistic microbiological hazard for the consumers’ health or life. Food-borne disease outbreaks associated with Campylobacter spp., Salmonella spp., shigatoxin-producing Escherichia coli, Brucella melitensis, Mycobacterium bovis and tick-borne encephalitis virus have been traced to the consumption of raw milk, however, many other microorganisms that can be present in milk are considered as potential food-borne pathogens to humans. The other common causative agents in food-borne disease outbreaks are bacterial toxins produced by Bacillus, Clostridium and Staphylococcus spp. Some of the milk pathogens harbour antimicrobial resistant genes, which can be transferred to commensal bacteria. Most dangerous are methicillin-resistant Staphylococcus aureus and extended spectrum beta lactamase/AmpC gene-carrying bacteria from the family of Enterobacteriaceae, which might negatively affect the treatment of infections in humans. Fungi are not considered as food-borne pathogens for humans, however their secondary metabolites, mycotoxins, constitute a potential threat to public health. Mycotoxins or their metabolites detected so far in milk samples include aflatoxins, ochratoxin A, zearalenone and its metabolites, fumonisins, de-epoxy-deoxynivalenol and cyclopiazonic acid.

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  • AbdelHameed K.G. (2016). Detection of Prototheca zopfii in raw milk and cheese with special reference to their antibiogram. J. Food Safety 36: 214–219.

  • Abeer A.A. Gouda A.S. Dardir H.A. Ibrahim A.K. (2012). Prevalence of some milk borne bacterial pathogens threatening camel milk consumers in Egypt. Global Vet. 8: 76–82.

  • Adejumo O. Atanda O. Raiola A. Bandyopadhyay R. Somorin Y. Ritieni A. (2013). Correlation between aflatoxin M1 content of breast milk dietary exposure to aflatoxin B1 and socioeconomic status of lactating mothers in Ogun State Nigeria. Food Chem. Toxicol. 56: 171–177.

  • Al-Tofaily Y.I.Kh. Al rodhan M.A.N. (2011). Study of clinical mastitis (bacteriological) in she-camels (Camelus dromedarius) in some areas of middle Euphrates in Iraq. J. Vet. Med. Sci. 10: 66–76.

  • Assem E. Mohamad A. Oula E.A. (2011). A survey on the occurrence of aflatoxin M1 in raw and processed milk samples marketed in Lebanon. Food Control 22: 1856–1858.

  • Barash J.R. Hsia J.K. Arnon S.S. (2010). Presence of soil-dwelling clostridia in commercial powdered infant formulas. J. Pediatr. 156: 402–408.

  • Bianchi D.M. Barbaro A. Gallina S. Vitale N. Chiavacci L. Caramelli M. Decastelli L. (2013). Monitoring of foodborne pathogenic bacteria in vending machine raw milk in Piedmont Italy. Food Control 32: 435–439.

  • Bielaszewska M. Janda J. Bláhová K. Minaříková H. Jíková E. Karmali M.A. Laubová J. Sikulová J. Preston M.A. Khakhria R. Karch H. Klazarová H. Nyc O. (1997). Human Escherichia coli O157:H7 infection associated with the consumption of unpasteurized goat’s milk. Epidemiol. Infect. 119: 299–305.

  • Bilandžić N. Božić Đ. Đokić M. Sedak M. Kolanović B.S. Varenina I. Tanković S. Cvetnić Ž. (2014 a). Seasonal effect on aflatoxin M1 contamination in raw and UHT milk from Croatia. Food Control 40: 260–264.

  • Bilandžić N. Božić Đ. Đokić M. Sedak M. Kolanović B.S. Varenina I. Cvetnić Ž. (2014 b). Assessment of aflatoxin M1 contamination in the milk of four dairy species in Croatia. Food Control 43: 18–21.

  • Boudra H. Barnouin J. Dragacci S. Morgavi D.P. (2007). Aflatoxin M1 and ochratoxin a in raw bulk milk from French dairy herds. J. Dairy Sci. 90: 3197–3201.

  • Braun-Fahrländer C. von Mutius E. (2011). Can farm milk consumption prevent allergic diseases? Clin. Exp. Allergy 41: 29–35.

  • Britzi M. Friedman S. Miron J. Solomon R. Cuneah O. Shimshoni J.A. Soback S. Ashkenazi R. Armer S. Shlosberg A. (2013). Carry-over of aflatoxin B1 to aflatoxin M1 in high yielding Israeli cows in mid- and late-lactation. Toxins 5: 173–183.

  • Caini S. Szomor K. Ferenczi E. Székelyné Gáspár Á. Csohán Á. Krisztalovics K. Molnár Z. Horváth J.K. (2012). Tick-borne encephalitis transmitted by unpasteurised cow milk in western Hungary September to October 2011. Euro Surveill. 17 20128.

  • Cavallarin L. Antoniazzi S. Giaccone D. Tabacco E. Borreani G. (2014). Transfer of aflatoxin M1 from milk to ripened cheese in three Italian traditional production methods. Food Control 38: 174–177.

  • Cisak E. Wójcik-Fatla A. Zając V. Sroka J. Buczek A. Dutkiewicz J. (2010). Prevalence of tick-borne encephalitis virus (TBEV) in samples of raw milk taken randomly from cows goats and sheep in eastern Poland. Ann. Agric. Environ. Med. 17: 283–286.

  • Claeys W.L. Verraes C. Cardoen S. De Block J. Huyghebaert A. Raes K. Dewettinck K. Herman L. (2014). Consumption of raw or heated milk from different species: an evaluation of the nutritional and potential health benefits. Food Control 42: 188–201.

  • Debarry J. Garn H. Hanuszkiewicz A. Dickgreber N. Blümer N. von Mutius E. Bufe A. Gatermann S. Renz H. Holst O. Heine H. (2007). Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties. J. Allergy Clin. Immunol. 119: 1514–1521.

  • Delavenne E. Mounier J. Asmani K. Jany J.-L. Barbier G. Le Blay G. (2011). Fungal diversity in cow goat and ewe milk. Int. J. Food Microbiol. 151: 247–251.

  • Doran P. Carson J. Costello E. More S. (2009). An outbreak of tuberculosis affecting cattle and people on an Irish dairy farm following the consumption of raw milk. Ir. Vet. J. 62: 390–397.

  • Doyle C.J. Gleeson D. Jordan K. Beresford T.P. Ross R.P. Fitzgerald G.F. Cotter P.D. (2015). Anaerobic sporeformers and their significance with respect to milk and dairy products. Int. J. Food Microbiol. 197: 77–87.

  • Dworecka-Kaszak B. Krutkiewicz A. Szopa D. Kleczkowski M. Biegańska M. (2012). High prevalence of Candida yeast in milk samples from cows suffering from mastitis in Poland. Sci. World J. 2012: 1–5.

  • EFSA (2004). Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to aflatoxin B1 as undesirable substance in animal feed. EFSA J. 39: 1–27.

  • EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards) (2015). Scientific opinion on the public health risks related to the consumption of raw drinking milk. EFSA J. 13: 3940 95 pp.

  • EFSA and ECDC (European Food Safety Authority and European Centre for Disease Prevention and Control) (2015 a). The European Union summary report on trends and sources of zoonoses zoonotic agents and food-borne outbreaks in 2013. EFSA J. 13: 3991 162 pp.

  • EFSA and ECDC (European Food Safety Authority and European Centre for Disease Prevention and Control) (2015 b). EU Summary Report on antimicrobial resistance in zoonotic and indicator bacteria from humans animals and food in 2013. EFSA J. 13: 4036 178 pp.

  • Egger-Danner C. Cole J.B. Pryce J.E. Gengler N. Heringstad B. Bradley A. Stock K.F. (2015). Invited review: overview of new traits and phenotyping strategies in dairy cattle with a focus on functional traits. Animal 9: 191–207.

  • El-Hoshy S.M. (1999). Occurrence of zearalenone in milk meat and their products with emphasis on influence of heat treatments on its level. Archiv. Für Lebensmittelhygiene 50: 140–143.

  • El-Sayed A.A. Soher E.A. Neamat-Allah A.A. (2002). Human exposure to mycotoxins in Egypt. Mycotoxin Res. 18: 23–30.

  • European Commission (2010). Commission Regulation (EU) No 165/2010 of 26 February 2010 amending Regulation (EC) No 1881/2006 setting maximum levels for certain contaminants in foodstuffs as regards aflatoxins. Off. J. Eur. Union 50: 8–12.

  • European Commission (2004). Regulation (EC) No 853/2004 of the European Parliament and of the Council of 29 April 2004 laying down specific hygiene rules for food of animal origin. Off. J. Eur. Union L139: 55–205; Corrigendum: Off. J. Eur. Union L226: 22–82.

  • European Commission (2009). Regulation (EC) No 470/2009 of the European Parliament and of the Council of 6 May 2009 laying down Community procedures for the establishment of residue limits of pharmacologically active substances in foodstuffs of animal origin repealing Council Regulation (EEC) No 2377/90 and amending Directive 2001/82/EC of the European Parliament and of the Council and Regulation (EC) No 726/2004 of the European Parliament and of the Council. Off. J. Eur. Union L152: 11–22.

  • FAO (2006). World agriculture: towards 2030/2050: prospects for food nutrition agriculture and major commodity groups. FAO Rome.

  • Faye B. Konuspayeva G. (2012). The sustainability challenge to the dairy sector – the growing importance of non-cattle milk production worldwide. Int. Dairy J. 24: 50–56.

  • FDA (2005). Compliance policy guide CPG Sec. 527.400 whole milk lowfat milk skim milk – Aflatoxin M1 U.S. Food and Drug Administration. http://www.fda.gov/ICECI/ComplianceManuals/CompliancePolicyGuidanceManual/ucm074482.htm

  • Fink-Gremmels J. (2008). Mycotoxins in cattle feeds and carry-over to dairy milk: a review. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 25: 172–180.

  • Flores-Flores M.E. Lizarraga E. López de Cerain A. González-Peñas E. (2015). Presence of mycotoxins in animal milk: a review. Food Control 53: 163–176.

  • Fotou K. Tzora A. Voidarou C. Alexopoulos A. Plessas S. Avgeris I. Bezirtzoglou E. Akrida-Demertzi K. Demertzis P.G. (2011). Isolation of microbial pathogens of subclinical mastitis from raw sheep’s milk of Epirus (Greece) and their role in its hygiene. Anaerobe 17: 315–319.

  • FSA (1999). Microbiological survey of unpasteurised sheep goats’ and buffaloes’ milk (1997–1999). Summary report MAFF Department of Health and the Scottish Executive Food Standards Agency Scotland UK.

  • Gazzotti T. Lugoboni B. Zironi E. Barbarossa A. Serraino A. Pagliuca G. (2009). Determination of fumonisin B1 in bovine milk by LC–MS/MS. Food Control 20: 1171–1174.

  • Gerosa S. Skoet J. (2012). Milk availability – trends in production and demand and medium-term outlook. Rome (Italy): FAO United Nations. http://www.fao.org/docrep/015/an450e/an450e00.pdf

  • Ghanem I. Orfi M. (2009). Aflatoxin M1 in raw pasteurized and powdered milk available in the Syrian market. Food Control 20: 603–605.

  • Ghidini S. Zanardi E. Battaglia A. Varisco G. Ferretti E. Campanini G. Chizzolini R. (2005). Comparison of contaminant and residue levels in organic and conventional milk and meat products from northern Italy. Food Addit. Contam. 22: 9–14.

  • Grant D.W. Carlson F.W. (1971). Partitioning behavior of aflatoxin M1 in dairy products. Bull. Environ. Contam. Toxicol. 6: 521–524.

  • Grosu-Tudor S.S. Zamfir M. Vander Meulen R. Falony G. De Vuyst L. (2013). Prebiotic potential of some exopolysaccharides produced by lactic acid bacteria. Rom. Biotechnol. Lett. 18: 8666–8676.

  • Gürbay A. Sabuncuoğlu S.A. Girgin G. Şahin G. Yiğit Ş. Yurdakök M. Tekinalp G. (2010). Exposure of newborns to aflatoxin M1 and B1 from mothers’ breast milk in Ankara Turkey. Food Chem. Toxicol. 48: 314–319.

  • Hameed K.G.A. Sender G. Korwin-Kossakowska A. (2006). Public health hazard due to mastitis in dairy cows. Anim. Sci. Pap. Rep. 25 73–85.

  • Harris N.V. Kimball T.J. Bennett P. Johnson Y. Wakely D. Nolan C.M. (1987). Campylobacter jejuni enteritidis associated with raw goat’s milk. Am. J. Epidemiol. 126: 179–186.

  • Heidinger J.C. Winter C.K. Cullor J.S. (2009). Quantitative microbial risk assessment for Staphylococcus aureus and Staphylococcus enterotoxin A in raw milk. J. Food Prot. 72: 1641–1653.

  • Heshmati A. Milani J.M. (2010). Contamination of UHT milk by aflatoxin M1 in Iran. Food Control 21: 19–22.

  • Hu D.L. Nakane A. (2014). Mechanisms of staphylococcal enterotoxin-induced emesis. Eur. J. Pharmacol. 722: 95–107.

  • Huang L.C. Zheng N. Zheng B.Q. Wen F. Cheng J.B. Han R.W. Xu X.M. Li S.L. Wang J.Q. (2014). Simultaneous determination of aflatoxin M1 ochratoxin A zearalenone and α-zearalenol in milk by UHPLC-MS/MS. Food Chemistry 146: 242–249.

  • Hudopisk N. Korva M. Janet E. Simetinger M. Grgič-Vitek M. Gubenšek J. Natek V. Kraigher A. Strle F. Avšič-Županc T. (2013). Tick-borne encephalitis associated with consumption of raw goat milk Slovenia 2012. Emerg. Infect. Dis. 19: 806–808.

  • Jasutiene I. Kulikauskiene M. Garmiene G. (2007). Stability of aflatoxin M-1 during production of fermented dairy products. Vet. Zootech.-Lith. 37: 20–23.

  • Jay-Russell M.T. Mandrell R.E. Yuan J. Bates A. Manalac R. Mohle-Boetani J. Kimura A. Lidgard J. Miller W.G. (2013). Using major outer membrane protein typing as an epidemiological tool to investigate outbreaks caused by milk-borne Campylobacter jejuni isolates in California. J. Clin. Microbiol. 51: 195–201.

  • Johnson E.A. Tepp W.H. Bradshaw M. Gilbert R.J. Cook P.E. McIntosh E.D.G. (2005). Characterization of Clostridium botulinum strains associated with an infant botulism case in the United Kingdom. J. Clin. Microbiol. 43: 2602–2607.

  • Kearney J. (2010). Food consumption trends and drivers. Philos. Trans. R. Soc. B Biol. Sci. 365: 2793–2807.

  • Kohl I. Kozuch O. Elecková E. Labuda M. Zaludko J. (1996). Family outbreak of alimentary tick-borne encephalitis in Slovakia associated with a natural focus of infection. Eur. J. Epidemiol. 12: 373–375.

  • Kosicki R. Błajet-Kosicka A. Twarużek M. Zastempowska E. Grajewski J. (2015). Determination of aflatoxin M1 in milk and powdered milk. 37th Mycotoxin Workshop – Conference Abstracts p. 74.

  • Ksouri S. Djebir S. Hadef Y. Benakhla A. (2015). Survey of bovine mycotic mastitis in different mammary gland statuses in two north-eastern regions of Algeria. Mycopathologia 179: 327–331.

  • Kuang Y. Tani K. Synnott A.J. Ohshima K. Higuchi H. Nagahata H. Tanji Y. (2009). Characterization of bacterial population of raw milk from bovine mastitis by culture-independent PCR–DGGE method. Biochem. Eng. J. 45: 76–81.

  • Lagneau P.E. Lebtahi K. Swinne D. (1996). Isolation of yeasts from bovine milk in Belgium. Mycopathologia 135: 99–102.

  • Lavoie K. Touchette M. St-Gelais D. Labrie S. (2012). Characterization of the fungal microflora in raw milk and specialty cheeses of the province of Quebec. Dairy Sci. Technol. 92: 455–468.

  • Londoño V.A.G. Boasso A. Paula M.C.Z. Garcia L.P. Scussel V.M. Resnik S. Pacín A. (2013). Aflatoxin M1 survey on randomly collected milk powder commercialized in Argentina and Brazil. Food Control 34: 752–755.

  • Losito I. Monaci L. Aresta A. Zambonin C.G. (2002). LC-ion trap electrospray MS-MS for the determination of cyclopiazonic acid in milk samples. The Analyst 127: 499–502.

  • Magoha H. De Meulenaer B. Kimanya M. Hipolite D. Lachat C. Kolsteren P. (2014). Fumonisin B1 contamination in breast milk and its exposure in infants under 6 months of age in Rombo Northern Tanzania. Food Chem. Toxicol. 74: 112–116.

  • Malinowski E. Lassa H. Klossowska A. Kuzma K. (2001). Enzymatic activity of yeast species isolated from bovine mastitis. Bull. Vet. Inst. Pulawy 45: 289–295.

  • Maragos C.M. Richard J.L. (1994). Quantitation and stability of fumonisins Bl and B2 in milk. J. AOAC Int. 77: 1162–1167.

  • Marin S. Ramos A.J. Cano-Sancho G. Sanchis V. (2013). Mycotoxins: occurrence toxicology and exposure assessment. Food Chem. Toxicol. 60: 218–237.

  • Martin A. Beutin L. (2011). Characteristics of Shiga toxin-producing Escherichia coli from meat and milk products of different origins and association with food producing animals as main contamination sources. Int. J. Food Microbiol. 146: 99–104.

  • Matuszczyk I. Tarnowska H. Zabicka J. Gut W. (1997). The outbreak of an epidemic of tick-borne encephalitis in Kielce province induced by milk ingestion (in Polish). Przegl. Epidemiol. 51: 381–388.

  • McAuley C.M. McMillan K. Moore S.C. Fegan N. Fox E.M. (2014). Prevalence and characterization of foodborne pathogens from Australian dairy farm environments. J. Dairy Sci. 97: 7402–7412.

  • Meucci V. Razzuoli E. Soldani G. Massart F. (2010). Mycotoxin detection in infant formula milks in Italy. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 27: 64–71.

  • Meucci V. Soldani G. Razzuoli E. Saggese G. Massart F. (2011). Mycoestrogen pollution of Italian infant food. J. Pediatr. 159: 278–283.

  • Micco C. Ambruzzi M.A. Miraglia M. Brera C. Onori R. Benelli L. (1991). Contamination of human milk with ochratoxin A. IARC Sci. Publ. 115: 105–108.

  • Moravek M. Dietrich R. Buerk C. Broussolle V. Guinebretière M.H. Granum P.E. Nguyen-The C. Märtlbauer E. (2006). Determination of the toxic potential of Bacillus cereus isolates by quantitative enterotoxin analyses. FEMS Microbiol Lett. 257: 293–298.

  • Muñoz K. Campos V. Blaszkewicz M. Vega M. Alvarez A. Neira J. Degen G.H. (2010). Exposure of neonates to ochratoxin A: first biomonitoring results in human milk (colostrum) from Chile. Mycotoxin Res. 26: 59–67.

  • Muñoz K. Wollin K.M. Kalhoff H. Degen G.H. (2013). Occurrence of the mycotoxin ochratoxin A in breast milk samples from Germany (in German). Gesundheitswesen 75: 194–197.

  • Muñoz K. Blaszkewicz M. Campos V. Vega M. Degen G.H. (2014). Exposure of infants to ochratoxin A with breast milk. Arch. Toxicol. 88: 837–846.

  • Murphy S.C. Boor K.J. (2000). Sources and causes of high bacteria counts in raw milk: an abbreviated review. Dairy Food Env. Sanitation. [cited 2010 May 3]20: 1–4. Available from: http://www.extension.org/pages/Sources_and_Causes_of_High_Bacteria_Counts_in_Raw_Milk:_An_Abbreviated_Review

  • Navas S.A. Sabino M. Rodriguez-Amaya D.B. (2005). Aflatoxin M(1) and ochratoxin A in a human milk bank in the city of Sao Paulo Brazil. Food Addit. Contam. 22: 457–462.

  • Oliveira C.A. Rosmaninho J. Rosim R. (2006). Aflatoxin M1 and cyclopiazonic acid in fluid milk traded in Sao Paulo Brazil. Food Addit. Contam. 23: 196–201.

  • Oliver S.P. Jayarao B.M. Almeida R.A. (2005). Foodborne pathogens in milk and the dairy farm environment: food safety and public health implications. Foodborne Pathog. Dis. 2: 115–129.

  • Oliver S.P. Boor K.J. Murphy S.C. Murinda S.E. (2009). Food safety hazards associated with consumption of raw milk. Foodborne Pathog. Dis. 6: 793–806.

  • Passchyn P. Piepers S. De Meulemeester L. Boyen F. Haesebrouck F. De Vliegher S. (2012). Between-herd prevalence of Mycoplasma bovis in bulk milk in Flanders Belgium. Res. Vet. Sci. 92: 219–220.

  • Pattono D. Gallo P.F. Civera T. (2011). Detection and quantification of ochratoxin A in milk produced in organic farms. Food Chem. 127: 374–377.

  • Pattono D. Grosso A. Stocco P.P. Pazzi M. Zeppa G. (2013). Survey of the presence of patulin and ochratoxin A in traditional semi-hard cheeses. Food Control 33: 54–57.

  • Pol M. Ruegg P.L. (2007). Relationship between antimicrobial drug usage and antimicrobial susceptibility of Gram-positive mastitis pathogens. J. Dairy Sci. 90: 262–273.

  • Polychronaki N. Turner C.P. Mykkänen H. Gong Y. Amra H. Abdel-Wahhab M. El-Nezami H. (2006). Determinants of aflatoxin M1 in breast milk in a selected group of Egyptian mothers. Food Addit. Contam. 23: 700–708.

  • Postupolski J. Karłowski K. Kubik P. (2006). Ochratoxin A in maternal and foetal blood and in maternal milk. Rocz. PZH 57: 23–30.

  • Quigley L. O’Sullivan O. Stanton C. Beresford T.P. Ross R.P. Fitzgerald G.F. Cotter P.D. (2013). The complex microbiota of raw milk. FEMS Microbiol Rev. 37: 664–698.

  • Ramos J.M. Bernal E. Esguevillas T. Lopez-Garcia P. Gaztambide M.S. Gutierrez F. (2008). Non-imported brucellosis outbreak from unpasteurized raw milk in Moroccan immigrants in Spain. Epidemiol. Infect. 136: 1552–1555.

  • Ribeiro M.G. Lara G.H.B. Bicudo S.D. Souza A.V.G. Salerno T. Siqueira A.K. Geraldo J.S. (2007). An unusual gangrenous goat mastitis caused by Staphylococcus aureusClostridium perfringens and Escherichia coli co-infection. Arq. Bras. Med. Vet. Zootec. 59: 810–812.

  • Rubio R. Licon C.C. Berruga M.I. Molina M.P. Molina A. (2011). Short communication: Occurrence of aflatoxin M1 in the Manchego cheese supply chain. J. Dairy Sci. 94: 2775–2778.

  • Saini V. McClure J.T. Scholl D.T. Devries T.J. Barkema H.W. (2013). Herd-level relationship between antimicrobial use and presence or absence of antimicrobial resistance in gram-negative bovine mastitis pathogens on Canadian dairy farms. J. Dairy Sci. 96: 4965–4976.

  • Sándor G. (1984). Occurrence of mycotoxins in feeds animal organs and secretions. Acta Veterinaria Hungarica 32: 57–69.

  • Šarić L.Ć. Šarić B.M. Mandić A.I. Torbica A.M. Tomić J.M. Cvetković D.D. Okanović Đ.G. (2012). Antibacterial properties of domestic Balkan donkeys’ milk. Int. Dairy J. 25: 142–146.

  • Sawant A.A. Sordillo L.M. Jayarao B.M. (2005). A survey on antibiotic usage in dairy herds in Pennsylvania. J. Dairy Sci. 88: 2991–2999.

  • Scaglioni P.T. Becker-Algeri T. Drunkler D. Badiale-Furlong E. (2014). Aflatoxin B1 and M1 in milk. Anal. Chim. Acta 829: 68–74.

  • Schelin J. Wallin-Carlquist N. Cohn M.T. Lindqvist R. Barker G.C. Rådström P. (2011). The formation of Staphylococcus aureus enterotoxin in food environments and advances in risk assessment. Virulence 2: 580–592.

  • SCOOP (2003). Task 3.2.10 collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states. Subtask II: Zearalenone (pp. 239-482). European Commission Directorate-General Health and Consumer Protection. Scientific Cooperation on Questions Relating to Food.

  • Scott P.M. Delgado T. Prelusky D.B. Trenholm H.L. Miller J.D. (1994). Determination of fumonisins in milk. J. Environ. Sci. Health B 29: 989–998.

  • Şeker E. Yardimci H. (2008). First isolation of Escherichia coli O157:H7 from faecal and milk specimens from Anatolian water buffaloes (Bubalus bubalus) in Turkey. J. S. Afr. Vet. Assoc.79: 167–170.

  • Skaug M.A. (1999). Analysis of Norwegian milk and infant formulas for ochratoxin A. Food Addit. Contam. 16: 75–78.

  • Skaug M.A. Helland I. Solvoll K. Saugstad O.D. (2001). Presence of ochratoxin A in human milk in relation to dietary intake. Food Addit. Contam. 18: 321–327.

  • Solomakos N. Govaris A. Angelidis A.S. Pournaras S. Burriel A.R. Kritas S.K. Papageorgiou D.K. (2009). Occurrence virulence genes and antibiotic resistance of Escherichia coli O157 isolated from raw bovine caprine and ovine milk in Greece. Food Microbiol. 26: 865–871.

  • Sørensen L.K. Elbæk T.H. (2005). Determination of mycotoxins in bovine milk by liquid chromatography tandem mass spectrometry. J. Chromatogr. B Analytical Technologies in the Biomedical and Life Sciences 820: 183–196.

  • Srinivasan V. Sawant A.A. Gillespie B.E. Headrick S.J. Ceasaris L. Oliver S.P. (2006). Prevalence of enterotoxin and toxic shock syndrome toxin genes in Staphylococcus aureus isolated from milk of cows with mastitis. Foodborne Pathog. Dis. 3: 274–283.

  • Tacket C.O. Dominguez L.B. Fisher H.J. Cohen M.L. (1985). An outbreak of multiple-drug-resistant Salmonella enteritis from raw milk. JAMA 253: 2058–2060.

  • Te Giffel M.C. Wagendorp A. Herrewegh A. Driehuis F. (2002). Bacterial spores in silage and raw milk. A. Van Leeuw. 81: 625–630.

  • Tolle A. (1980). The microflora of the udder. Bull. Int. Dairy Fed. 120 p. 4.

  • Turconi G. Guarcello M. Livieri C. Comizzoli S. Maccarini L. Castellazzi A.M. Pietri A. Piva G. Roggi C. (2004). Evaluation of xenobiotics in human milk and ingestion by the newborn – an epidemiological survey in Lombardy (Northern Italy). Eur. J. Nutr. 43: 191–197.

  • van Hooijdonk T. Hettinga K. (2015). Dairy in a sustainable diet: a question of balance. Nutr. Rev. 73 Suppl. 1: 48–54.

  • Vendramin T. Kich D.M. Molina R.D. de Souza C.F.V. Salvatori R.U. Pozzobon A. Bustamante-Filho I.C. (2014). Molecular screening of bovine raw milk for the presence of Shiga toxin-producing Escherichia coli (STEC) on dairy farms. Food Sci. Technol 34: 604–608.

  • Verraes C. Claeys W. Cardoen S. Daube G. De Zutter L. Imberechts H. Dierick K. Herman L. (2014). A review of the microbiological hazards of raw milk from animal species other than cows. Int. Dairy J. 39: 121–130.

  • Veršilovskis A. Van Peteghem C. De Saeger S. (2009). Determination of sterigmatocystin in cheese by high-performance liquid chromatography-tandem mass spectrometry. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 26: 127–133.

  • WHO (2001). Global strategy for containment of antimicrobial resistance. World Health Organization.

  • Xia X. Li X. Ding S. Zhang S. Jiang H. Li J. Shen J. (2009). Ultra-high-pressure liquid chromatography-tandem mass spectrometry for the analysis of six resorcylic acid lactones in bovine milk. J. Chromatogr. A 1216 2587–2591.

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Source Normalized Impact per Paper (SNIP) 2018: 0.869

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