Deep Venous Thrombosis Associated With Inferior Vena Cava Abnormalities And Hypoplastic Kidney In Siblings

Open access

Abstract

Congenital inferior vena cava anomalies have a reduced frequency in general population, many times being an asymptomatic finding. Patients caring such anomalies are at risk to develop deep vein thrombosis. In this paper, we present 2 siblings with deep venous thrombosis and inferior vena cava abnormalities, with a symptomatic onset at similar age. The inferior vena cava abnormality was documented by an angio-CT in each case. The thrombophilic workup was negative. Patients were treated with conservative therapy: low molecular weight heparin anticoagulants converted later to oral anticoagulant with resolution of symptoms and disappearance of the thrombus. Finally, in the absence of any risk factor in a young patient admitted with deep vein thrombosis investigations to exclude inferior vena cava anomalies are mandatory.

1. Kalicki B, Sadecka M, Wawrzyniak A, et al. Absence of inferior vena cava in 14-year old boy associated with deep venous thrombosis and positive Mycoplasma pneumoniae serum antibodies- a case report. BMC Pediatr. 2015;15:40.

2. Bami S, Vazquez Y, Chorny V, Goldfisher R, Amodio J. Deep Venous Thrombosis of the Leg, Associated with Agenesis of the Infrarenal Inferior Vena Cava and Hypoplastic Left Kidney (KILT Syndrome) in a 14-Year-Old Child,”. Case Reports Pediatr. 2015;2015:864047.

3. Lambert M, Marboeuf P, Midulla M, et al. Inferior vena cava agenesis and deep vein thrombosis: 10 patients and review of the literature. Vasc Med. 2010;15:451-459.

4. Pop Sorin, Opincaru Iulianu. Anomalies of the inferior vena cava in patients with deep venous thrombosis. Pictorial essay. Medical Ultrasonography 2012;14:53-59.

5. Lesanu G, Balanescu R, Pacurar D, et al. Complex Malformation of the Inferior Vena Cava. Chirurgia 2014;109:259-262.

6. Spentzouris G, Zandian A, Cesmebasi A et al. The clinical anatomy of the inferior vena cava: a review of common congenital anomalies and considerations for clinicians. Clinical Anatomy, 2014;27:1234–1243.

7. Konopka CL, Salame M, Padulla GA, Muradás RR, Batistella JC. Deep venous thrombosis associated with agenesis of IVC. J Vasc Bras 2010;9:196-169.

8. Sitwala PS, Ladia VM, Brahmbhatt PB, Jain V, Bajaj K. Inferior Vena Cava Anomaly: A Risk for Deep Vein Thrombosis N Am J Med Sci. 2014;6:601–603.

9. Sagban TA, Scharf RE, Wagenhäuser MU, et al. Elevated risk of thrombophilia in agenesis of the vena cava as a factor for deep vein thrombosis Sagban et al. Orphanet Journal of Rare Diseases 2015;10:3.

10. G. Gayer, R. Zissin, S. Strauss, M. Hertz. IVC anomalies and right renal aplasia detected on CT: a possible link? Abdominal Imaging. 2003;28:395-399.

11. Van Veen J, Hampton KK, Makris M. Kilt syndrome? Br J Haematol. 2002;118:1199-2000.

12. Gil RJ, Pérez AM, Arias JB, Pascual FB, Romero ES. Agenesis of the inferior vena cava associated with lower extremities and pelvic venous thrombosis. J Vasc Surg. 2006;44:1114-1116.

Acta Medica Marisiensis

The Journal of The University of Medicine and Pharmacy of Targu-Mures

Journal Information

Cited By

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 65 65 9
PDF Downloads 16 16 1