Correlations Between Severity of Coronary Calcification and Impairment of Left Ventricular Ejection Fraction

Open access


Introduction: 64 multislice CT angiography is a recently introduced imaging technique, increasingly being used as a tool to show the coronary arteries in three-dimensional visualization. One of the advantages of this method is the ability to estimate the degree of calcification of atheromatous plaques via coronary calcium score calculation, which correlates with the severity score of ateromatous systemic burden. The aim of this study was to evaluate the relationship between the severity of coronary calcification, expressed by calcium score, and the left ventricular ejection fraction (LVEF). Material and methods: This retrospective study included 81 patients with symptoms of angina and ECG modifications (at rest or during exercise). Echocardiography and 64 multislice CT angiography were performed in all patients to assess the LVEF and Ca scoring. Results: Calcium score was lower than 100 in 62 patients (50.22%), between 100 and 400 in 11 patients (8.91%), and higher than 400 in 8 patients (6.48%). Mean LVEF was 53.52%, 17 patients having an LVEF of less than 50%. In patients with calcium score less than 100, the corresponding ejection fraction was normal: 55.29%, while in coronary arteries with extensive calcifications (calcium score > 400), the LVEF was significantly lower, 50.5% (p = 0.004). Conclusions: High Calcium score is positively correlated with LVEF reduction, and a high value for calcium score indicates an increased probability of reduced left ventricular ejection fraction

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Meijboom WB Meijs MF Schuijf JD et al. Diagnostic accuracy of 64-slice computed tomography coronary angiography: a prospective multicenter multivendor study. J Am Coll Cardiol. 2008;52:2135-2144.

  • 2. Bluemke DA Achenbach S Budoff M et al. Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: A Scientifi c Statement From the American Heart Association Committee on Cardiovascular Imaging and Intervention of the Council on Cardiovascular Radiology and Intervention and the Councils on Clinical Cardiology and Cardiovascular Disease in the Young. Circulation. 2008;118:586-606.

  • 3. Greenland P Bonow RO Brundage BH et al. ACCF/AHA 2007 Clinical Expert Consensus Document on Coronary Artery Calcium Scoring By Computed Tomography in Global Cardiovascular Risk Assessment and in Evaluation of Patients With Chest Pain. Journal of the American College of Cardiology. 2007;49(3):378-402.

  • 4. Benedek T Gyongyosi M Benedek I. Multislice Computed Tomographic Coronary Angiography for Quantitative Assessment of Culprit Lesions in Acute Coronary Syndromes. Canadian Journal of Cardiology. 2013;29(3):364-371.

  • 5. Raggi P Khan A Arepali C Stillman AE. Coronary artery calcium scoring in the age of CT angiography: what is its role? Curr Atheroscler Rep. 2008; 10(5):438-43.

  • 6. Mark DB Berman DS Budoff MJ. ACCF/ACR/AHA/NASCI/SAIP/SCAI/ SCCT 2010 Expert Consensus Document on Coronary Computed Tomographic Angiography: A report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. J Am Coll Cardiol. 2010;55;2263-2699.

  • 7. Schroeder S Achenbach S Bengel F et al. Cardiac computed tomography: indications applications limitations and training requirements. European Heart Journal. 2008;29:531-556.

  • 8. Benedek T Bucur O Pascanu I Benedek I. Analysis of coronary plaque morphology by 64-multislice computed tomography coronary angiography and calcium scoring in patients with type 2 diabetes mellitus. Acta endocrinologica. 2011;7(1):59-68.

  • 9. Colletti M Dustin L Wong N et al. Does Coronary Calcium Score Predict Future Cardiac Function? Association of Subclinical Atherosclerosis with Left Ventricular Systolic and Diastolic Dysfunction at MR Imaging in an Elderly Cohort. Radiology. 2010;257(1):64-70.

  • 10. Edvardsen T Detrano R Rosen BD et al. Coronary Artery Atherosclerosis Is Related to Reduced Regional Left Ventricular Function in Individuals Without History of Clinical Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2006;26:206-211.

Journal information
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 164 79 2
PDF Downloads 69 43 0