Markers for Inflammation and Oxidative Stress in Patients with Coronary Artery Disease and Microvascular Disease – Is there a Difference?

Open access

Abstract

Introduction: The clinical significance of inflammation (and markers such as resistin, hsCRP) and oxidative stress (e.g. 8-isoprostanes) for microvascular disease (MVD) and coronary artery disease (CAD) is still elusive.

Aims: To determine the role of the markers for inflammation and oxidative stress as independent markers for MVD.

Methods: Ninety consecutive patients were recruited: twenty-five of them had CAD; thirty – MVD and thirty-five were controls. The latter included patients with atypical chest pain, risk factors, lack of coronary artery disease and negative adenosine test. Coronary angiography was performed in all participants. The adenosine test was performed in those without CAD, hs CRP, resistin in plasma and urine 8-isoprostanes were measured. The correlation of all these indicators with CAD and MVD was analyzed.

Results: The 8-isoprostanes showed significant differences between patients with MVD and CAD (0,055/0,52 pg/mmol Cre; p = 0,028). The same trend was found between CAD patients and the control group (0,055/0,003 pg/mmol Cre; p = 0,041); as well as between those with MVD and the control group (0,52/0,003 pg/mmol Cre; p = 0,001). The highest values of 8-isoprostanes were detected in patients with MVD – 0,52 pg/mmol Cre. Markers for inflammation were similar in patients with MVD and CAD (hsCRP- p = 0,091; resistin − p = 0,32).

Conclusions: hs CRP, resistin and 8-isoprostanes are involved in the pathogenesis of both CAD and MVD. However, oxidative stress is probably more important for MVD, therefore 8-isoprostanes can be a part of panel of markers for its detection and analysis.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Runev N Manov E. Diastolic left ventricular dysfunction – invasive assessment. 1st edition Maurice-France; LAP LAMBERT Academic Publishing 2014.

  • 2. Jasmin Č. Procedural Techniques of Coronary Angiography. Advances in the diagnosis of Coronary Atherosclerosis 2011;6: 95-121.

  • 3. Hector M Gogas B Serruys P et al. IVUS-based imaging modalities for tissue characterization: similarities and differences. Int J Cardiovasc Imaging 2011;21:215-224.

  • 4. Davi G Guagnano M Ciabattoni G et al. Platelet activation in obese women: role of inflammation and oxidant stress. JAMA 2002;288:2008-2014.

  • 5. Davi G Ciabattoni G Consoli M et al. In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation 1999;99:224-229.

  • 6. Minuz P Patrignani P Gaino S et al. Increased oxidative stress and platelet activation in patients with hypertension and renovascular disease. Circulation 2002;106:2800-2805.

  • 7. Lavie L Lavie P. Molecular mechanisms of cardioavascular disease in OSAHS: The oxidative stress link. European Resp J.2009;33:1467-1484.

  • 8. Higashi Y Noma K Yoshizumi M et al. Endothelial function and oxidative stress in cardiovascular diseases. Circ J.2009;73:411-418.

  • 9. Wu J Stevenson M Brown J et al. C-reactive protein enhances tissue factor expression by vascular smooth muscle cells: mechanisms and in vivo significance. Arterioscler Thromb Vasc Biol. 2008;28:698-704.

  • 10. Witteles R Fowler M. Insulin-resistant cardiomyopathy clinical evidence mechanisms and treatment options. J Am Coll Cardiol 2008;51:93-102.

  • 11. Bassuk S Rifai N Ridker P. High sensitive C-reactive protein: clinical importance. Curr. Probl. Cardiol 2004;29:439-493.

  • 12. Tomai F Ribichini F Ghini A et al. Elevated C-reactive protein levels and coronary microvascular dysfunction in patients with coronary artery disease. European Heart Journal 2005;26:2099-2105.

  • 13. Libby P Crea F. Clinical implications of inflammation for cardiovascular primary prevention. European Heart Journal 2010;31:777-783.

  • 14. Gencer B Auer R Rekeneire N et al. Association between resistin levels and cardiovascular disease events in older adults: The health aging and body composition study. Atherosclerosis 2016;245:181-186.

  • 15. Reilly M Lehrke M Wolfe M et al. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 2005;111:932-939.

  • 16. Tsioufis C Dimitriadis K Selima M et al. Association of resistin with urinary albumin excretion in nondiabetic patients with essential hypertension. Am J Hypertens 2010; 23(6)681-686.

  • 17. Sinan U Canbolat I Baydar O et al. Relationship between increased serum resistin level and severity of coronary artery disease. Angiology 2014; 65:239-242.

Search
Journal information
Metrics
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 44 44 34
PDF Downloads 35 35 30