The Adverse Health Effects of Shift Work in Relation to Risk of Illness/Disease: A Review


Biological rhythm of sleeping is a natural disparity in an organism corresponding to and in reply to cyclic environmental changes, such as daylight hours and hours of darkness or elevated and low down flow. There is some evidence, based upon epidemiological studies as well as studies upon smaller groups of subjects, that individuals who work during the night and sleep during the daytime show cognitive impairment at work, have poorer and fragmented daytime sleep, and have increased risks of developing a wide range of social, psychological, physiological and medical impairments and disorders. Circadian rhythms are one of the most important effective factors on the physiological and physical performances of humans and disturbing this normal rhythm leads to different groups of diseases. The majority of investigations in biological rhythm demeanor vary noticeably in regards to the exact type of disease, population and protocols of sampling over the other outcomes or issues. We conducted a systematic review of [Science Direct, Pubmed, Scopus] to identify influence of different kinds of diseases among shift workers in response to abnormal rhythm of sleeping. The results of this review indicate that abnormal patterns of sleeping can lead to immunological issues, hypertension, metabolic syndrome, insomnia, cardiovascular disease, obesity and depression. It is vital for subsequent investigations to find a way to reduce negative effects (such as decreased amount of works’ time and altered diet) without side effects to help them.

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  • 1. Faraut B, Bayon V, Léger D. Neuroendocrine, immune and oxidative stress in shift workers. Sleep medicine reviews, 17, 2013, 433-44.

  • 2. Scott A, LaDou J. Health and safety in shift workers. Occupational Medicine, 1994, 960-71.

  • 3. Harrington JM. Health effects of shift work and extended hours of work. Occupational and Environmental medicine, 58, 2001, 68-72.

  • 4. Atkinson G, Fullick S, Grindey C, Maclaren D. Exercise, energy balance and the shift worker. Sports Medicine, 38, 2008, 671-85.

  • 5. Saksvik IB, Bjorvatn B, Hetland H et al. Individual differences in tolerance to shift work-a systematic review. Sleep medicine reviews, 15, 2011, 221-35.

  • 6. Schaufeli WB, Taris TW. A critical review of the Job Demands-Resources Model: Implications for improving work and health. Bridging occupational, organizational and public health: Springer, 2014, 43-68.

  • 7. Monk TH, Folkard S. Making shiftwork tolerable: CRC Press, 1992.

  • 8. Arendt J. Shift work: coping with the biological clock. Occup. Med., 60, 2010, 10-20.

  • 9. Erren TC, Herbst C, Koch MS et al. Adaptation of shift work schedules for preventing and treating sleepiness and sleep disturbances caused by shift work. The Cochrane Library, 2013.

  • 10. Hublin C, Partinen M, Koskenvuo K et al. Shift-work and cardiovascular disease: a population-based 22-year follow-up study. Eur. J. Epidemiol., 25, 2010, 315-23.

  • 11. Bøggild H, Knutsson A. Shift work, risk factors and cardiovascular disease. Scand. J. Work Environ. Health, 1999, 85-99.

  • 12. Lyon F. IARC monographs on the evaluation of carcinogenic risks to humans, 1982.

  • 13. Kolstad HA. Nightshift work and risk of breast cancer and other cancers a critical review of the epidemiologic evidence. Scand. J. Work, Environ. Health, 2008, 5-22.

  • 14. Barger LK, Lockley SW, Rajaratnam SM et al. Neurobehavioral, health, and safety consequences associated with shift work in safety-sensitive professions. Curr. Neurol. Neurosc. Rep., 9, 2009, 155-64.

  • 15. Knutsson A. Health disorders of shift workers. Occup. Med., 53, 2003, 103-8.

  • 16. Lowden A, Moreno C, Holmbäck U et al. Eating and shift work-effects on habits, metabolism, and performance. Scand. J. Work, Environ. Health, 2010, 150-62.

  • 17. Åkerstedt T. Altered sleep/wake patterns and mental performance. Physiology & Behavior, 90, 2007, 209-18.

  • 18. Karlsson B, Knutsson A, Lindahl B. Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27 485 people. Occup. Environ. Med., 58, 2001, 747-52.

  • 19. Kawakami N, Haratani T, Araki S. Job strain and arterial blood pressure, serum cholesterol, and smoking as risk factors for coronary heart disease in Japan. Int. Arch. Occup. Environ. Health, 71, 1998, 429-32.

  • 20. Nagaya T, Yoshida H, Takahashi H, Kawai M. Markers of insulin resistance in day and shift workers aged 30-59 years. Int. Arch. Occup. Environ. Health, 75, 2002, 562-8.

  • 21. Hu G, Jousilahti P, Antikainen R, Tuomilehto J. Occupational, commuting, and leisure-time physical activity in relation to cardiovascular mortality among Finnish subjects with hypertension. American journal of hypertension, 20, 2007, 1242-50.

  • 22. De Bacquer D, Van Risseghem M, Clays E et al. Rotating shift work and the metabolic syndrome: a prospective study. International journal of epidemiology, 38, 2009, 848-54.

  • 23. Chen J-D, Lin Y-C, Hsiao S-T. Obesity and high blood pressure of 12-hour night shift female clean-room workers. Chronobiol. Int., 27, 2010, 334-44.

  • 24. Burgueño A, Gemma C, Gianotti TF et al. Increased levels of resistin in rotating shift workers: a potential mediator of cardiovascular risk associated with circadian misalignment. Atherosclerosis, 10, 2010, 625-9.

  • 25. Wang X, Armstrong M, Cairns B et al. Shift work and chronic disease: the epidemiological evidence. Occup. Med., 61, 2011, 78-89.

  • 26. Frost P, Kolstad HA, Bonde JP. Shift work and the risk of ischemic heart disease-a systematic review of the epidemiologic evidence. Scand. J. Work Environ. Health, 2009, 163-79.

  • 27. Gumenyuk V, Roth T, Drake CL. Circadian phase, sleepiness, and light exposure assessment in night workers with and without shift work disorder. Chronobiol. Int., 29, 2012, 928-36.

  • 28. Knutsson A, Akerstedt T. The healthy-worker effect: self-selection among Swedish shift workers. Work & Stress, 6, 1992, 163-7.

  • 29. Willis TA, O’Connor DB, Smith L. Investigating effort-reward imbalance and work-family conflict in relation to morningness-eveningness and shift work. Work & Stress, 22, 2008, 125-37.

  • 30. Härmä M. Workhours in relation to work stress, recovery and health. Scand. J. Work Environ. Health, 2006, 502-14.

  • 31. Albertsen K, Grimsmo KAKKA, Rafnsdóttir BASGL, Tómasson K. Working Time Arrangements and Social Consequences: What Do We Know?: Nordic Council of Ministers, 2007.

  • 32. Smith L, Jeppesen HJ, Bøggild H. Internal locus of control and choice in health service shift workers. Ergonomics, 50, 2007, 1485-502.

  • 33. Curti R, Radice L, Cesana G et al. Work stress and immune system: lymphocyte reactions during rotating shift work. Preliminary results. La Medicina del lavoro, 73, 1981, 564-9.

  • 34. Barton J, Smith L, Totterdell P et al. Does individual choice determine shift system acceptability? Ergonomics, 36, 1993, 93-9.

  • 35. Ryan B, Wilson JR, Sharples S et al. Rail signallers’ assessments of their satisfaction with different shift work systems. Ergonomics, 51, 2008, 1656-71.

  • 36. Nabe-Nielsen K. Shift Work, Health, and Well-being Among Eldercare Workers: Ph. D. Thesis: Faculty of Health Sciences, University of Copenhagen, 2011.

  • 37. Costa G, Haus E, Stevens R. Shift work and cancer considerations on rationale, mechanisms, and epidemiology. Scand. J. Work, Environ. Health, 2010, 163-79.

  • 38. Cabrera NL, Leckie JO. Pesticide risk communication, risk perception, and self-protective behaviors among farmworkers in California’s Salinas Valley. Hisp. J. Behavi. Sci., 31, 2009, 258-72.

  • 39. Esquirol Y, Perret B, Ruidavets JB et al. Shift work and cardiovascular risk factors: new knowledge from the past decade. Arch. Cardiovasc. Dis., 10, 2011, 636-68.

  • 40. Van Drongelen A, Boot CR, Merkus SL et al. The effects of shift work on body weight change - a systematic review of longitudinal studies. Scand. J. Work Environ. Health, 2011, 263-75.

  • 41. Wang F, Yeung K, Chan W, et al. A meta-analysis on dose-response relationship between night shift work and the risk of breast cancer. Ann. Oncol., 24, 2013, 2724-32.

  • 42. Backé E-M, Seidler A, Latza U et al. The role of psychosocial stress at work for the development of cardiovascular diseases: a systematic review. Int. Arch. Occup. Environ. Health, 85, 2012, 67-79.

  • 43. Holtermann A, Mortensen OS, Burr H et al. Long work hours and physical fitness: 30-year risk of ischaemic heart disease and all-cause mortality among middle-aged Caucasian men. Heart, 96, 2010, 1638-44.

  • 44. Roelen CA, Bültmann U, Groothoff J et al. Physical and mental fatigue as predictors of sickness absence among Norwegian nurses. Res. Nurs. Health, 36, 2013, 453-65.

  • 45. Chtourou H, Hammouda O, Souissi H. et al. Diurnal variations in physical performances related to football in young soccer players. Asian journal of sports medicine, 3, 2012,139-147.

  • 46. Shariat A, Kargarfard M, Tamrin SBM et al. Strength-training and biological rhythm of male sex hormone among judoists. Biol. Rhythm Res., 2014, 1-7.

  • 47. Chobanian A. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee: Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension, 42, 2003, 1206-52.

  • 48. Committee G. 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J. Hypert., 21, 2003, 1011-53.

  • 49. Parati G, Stergiou G, Asmar R et al. European Society of Hypertension practice guidelines for home blood pressure monitoring. J. Human Hypert., 24, 2010, 779-85.

  • 50. Colberg SR, Sigal RJ, Fernhall B et al. Exercise and Type 2 Diabetes The American College of Sports Medicine and the American Diabetes Association: joint position statement executive summary. Diab. care, 33, 2010, 2692-6.

  • 51. Franklin BA, Fagard R. Position stand. Medicine & Science in Sports & Exercise, 195, 2004, 3603-0533.

  • 52. May T. Qualitative research in action: Sage, 2002.


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