Administration of Bioflavonoides Improves Plasma Levels of Adipocyte Hormones

Open access

Summary

Since time immemorial the fruits of aronia melanocarpa (rich of bioflavonoides) have been known for their medicinal properties. Present-day research of the pharmacological effects of aronia melanocarpa juice and fruits intake indicates that their high contents of anthocyanins is closely related to the health enhancing properties of this plant. This is a key fact which can be used in the prevention of most commonly spread, socially significant diseases, reducing for instance the total risk of cardio-vascular diseases. The great molecular variety anthocyanins possess and the role they play in cell metabolism, are still being investigated. This gives grounds to study the effects of Aronia melanocarpa on human cells, tissues, and organs. The aim of this study is to trace the effect of 150-200 ml aronia melanokarpa juice daily oral intake on the adipocyte hormones leptin (Lp), resistine (Rs) and adiponectin (Adn) blood levels in 10 patients with high body mass index (BMI, kg/m2) and high waist circumference. We used ELISA methods for hormonal analyses. During the study-period of two months patients did not change anything in their lifestyle. In the study group, the levels of Rs, Lp and Adn changed significantly compared to their baseline levels (averages, ng/mL) - 6.93 ± 0.137, 18.40 ±1.021 and 7.98 ± 0.077 vs. 5.06 ± 0.011, 15.23 ± 0.906 and 10.45 ± 0.103 at the end of the second month, respectively. Compared with the control group of 6 people, matched for BMI, not receiving aronia melanocarpa juice, these values were markedly different. Patients taking aronia melanokarpa juice report improvement in various conditions that have caused them discomfort before the research started: pain in the muscles and joints faded away and were replaced by a new feeling of strength, headache attacks disappeared, improvement in memory and sleep were reported, regular defecation, no signs of gastric discomfort, better vision, a quicker auditory reaction, motivation for having sex, good mood were also reported. Obese patients with insulin resistance have decreased serum adiponectin and increased serum resistin and leptin. The levels of these three hormones changed positively after chronic intake of aronia juice. We recommend a daily intake of aronia juice for the prevention of health.

1 . Boncheva , M. Curative effects of the fruits of Aronia melanocarpa. - General medicine, 14, 2012, № 3, 39-48.

2 . Boncheva , M, G. Georgiev et V. Shishkov. Intake of aronia melanocarpa juice improves medical tests and the feeling of health in patients with non-alcoholic fatty liver disease. - General medicine, 15, 2013, № 2, 21-30.

3 . Boncheva , M, G. Tzolova et R. Dimova. Metabolic syndrome - The GP’s knowledge for this problem in Bulgaria. - Social medicine, 4, 2006, 5-8.

4 . Georgiev, G., M. Boncheva et M. Jordanova. Admission of juice aronia melanocarpa improves medical research and feeling for health in patients with metabolic syndrome. 22nd International Congress of Clinical Chemistry and Laboratory Medicine, 22-26 June, Istanbul, Turkey. Clinical Chemistry and Laboratory Medicine, abstract 0749, S922.

5 . Bohkyung , K. et al. Polyphenol-rich Aronia melanocarpa (chokeberry) extract regulates expression of cholesterol and lipid metabolism genes in Caco-2 cells. - FASEB J., 26, 2012, 251-262.

6 . Comprehensive Reviews in Food Science and Food Safety, 11, 2012.

7 . Agric , J . Chemical Compounds of aronia melanocarpa fruit. - Food Chem., 51, 2003, № 2, 142-149.

8 . Kulling , S. E. et al. Chokeberry (aronia melanocarpa) chemical compaunds. - Planta Med., 74, 2008, 1625-1634.

9 . Manach , C., G. Williamson, C. Morand, A. Scalbert et C. Rémésy. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. - Am. J. Clin. Nutrition, 81, 2005, 230S-242S.

10 . Stofkova , A. Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity. - Endocr. Regul., 18, 2009, 157-168.

11 . Solinas , G. et M. Karin Molecular links between obesity and metabolic dysfunction. - FASEB J., 18, 2010, 2596-2611.

Journal Information

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 173 128 4
PDF Downloads 72 63 6