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The research deals with metal extraction from off-grade ores and concentration tailings. There are provided results of simulating parameters of reagent leaching of metals in the disintegrator according to the metal recovery ratio. The research substantiates the method of waste-free processing of chemically recovered ores. Recovery of metals into solution is the same both under multiple leaching of tailings or ore in the disintegrator and agitation leaching of tailings or ore previously activated in the disintegrator with leaching solutions. The time of agitation leaching is more by two orders of magnitude than that of the disintegrator processing. Recovery of metals into solution is most affected by the content of sodium chloride in the solution. Then, in decreasing order, go the content of sulfuric acid in the solution, the disintegrator rotor rpm and L:S ratio.