Modifications of expression of genes and proteins involved in DNA repair and nitric oxide metabolism by carbatonides [disodium-2,6-dimethyl-1,4-dihydropyridine- 3,5-bis(carbonyloxyacetate) derivatives] in intact and diabetic rats

1. Chen X, Tang J, Xie W, Wang J, Jin J, Ren J, Jin L, Lu J. Protective effect of the polysaccharide from Ophiopogon japonicus on streptozotocin-induced diabetic rats. Carbohydr Polym 2013;94:378-85. doi: 10.1016/j.carbpol.2013.01.037Search in Google Scholar

2. Fu H, Li G, Liu C, Li J, Wang X, Cheng Liu T. Probucol prevents atrial remodeling by inhibiting oxidative stress and TNF-α/NF-κB/TGF-β signal transduction pathway in alloxan-induced diabetic rabbits. J Cardiovasc Electrophysiol 2015;26:211-22. doi: 10.1111/jce.12540Search in Google Scholar

3. Drígelová M, Tarabová B, Duburs G, Lacinová L. The dihydropyridine analogue cerebrocrast blocks both T-type and L-type calcium currents. Can J Physiol Pharmacol 2009;87:923-32. doi: 10.1139/y09-086Search in Google Scholar

4. Velena A, Zarkovic N, Gall Troselj K, Bisenieks E, Krauze A, Poikans J, Duburus G. 1,4-Dihydropyridine derivatives: dihydronicotinamide analogues-model compounds targeting oxidative stress. Oxid Med Cell Longev 2016;2016:1892412. doi: 10.1155/2016/1892412Search in Google Scholar

5. Fernandes MA, Pereira SP, Jurado AS, Custódio JB, Santos MS, Moreno AJ, Duburs G, Vicente JA. Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI- 1211 (etaftoron), and OSI-3802] on rat liver mitochondrial bioenergetics and on the physical properties of membrane lipid bilayers: relevance to the length of the alkoxyl chain in positions 3 and 5 of the DHP ring. Chem Biol Interact 2008;173:195-204. doi: 10.1016/j.cbi.2008.03.001Search in Google Scholar

6. Briede J, Stivrina M, Stoldere D, Vigante B, Duburs G. Effect of cerebrocrast on body and organ weights, food and water intake, and urine output of normal rats. Cell Biochem Funct 2008;26:908-15. doi: 10.1002/cbf.1525Search in Google Scholar

7. Briede J, Stivriņa M, Stoldere D, Bisenieks E, Uldriķis J, Poikāns J, Makarova N, Duburs G. Effect of new and known 1,4-dihydropyridine derivatives on blood glucose levels in normal and streptozotocin-induced diabetic rats. Cell Biochem Funct 2004;22:219-24. doi: 10.1002/cbf.1091Search in Google Scholar

8. Briede J, Stivrina M, Stoldere D, Vigante B, Duburs G. Effect of cerebrocrast, a new long-acting compound on blood glucose and insulin levels in rats when administered before and after STZ-induced diabetes mellitus. Cell Biochem Funct 2007;25:673-80. doi: 10.1002/cbf.1372Search in Google Scholar

9. Briede J, Stivrina M, Vigante B, Stoldere D, Duburs G. Acute effect of antidiabetic 1,4-dihydropyridine compound cerebrocrast on cardiac function and glucose metabolism in the isolated, perfused normal rat heart. Cell Biochem Funct 2008;26:238-45. doi: 10.1002/cbf.1442Search in Google Scholar

10. Leonova E, Sokolovska J, Boucher JL, Isajevs S, Rostoka E, Baumane L, Sjakste T, Sjakste N. New 1,4-dihydropyridines down-regulate nitric oxide in animals with streptozotocininduced diabetes mellitus and protect deoxyribonucleic against peroxynitrite action. Basic Clin Pharmacol Toxicol 2016;119:19-31. doi: 10.1111/bcpt.12542Search in Google Scholar

11. Ryabokon NI, Goncharova RI, Duburs G, Rzeszowska- Wolny J. A 1,4-dihydropyridine derivative reduces DNA damage and stimulates DNA repair in human cells in vitro. MutatRes2 0 0 5 ; 5 8 7 : 5 2 - 8 . d o i : 1 0 . 1 0 1 6 / j . mrgentox.2005.07.009Search in Google Scholar

12. Buraka E, Chen CY, Gavare M, Grube M, Makarenkova G, Nikolajeva V, Bisenieks I, Brūvere I, Bisenieks E, Duburs G, Sjakste N. DNA-binding studies of AV-153, an antimutagenic and DNA repair-stimulating derivative of 1,4-dihydropiridine. Chem Biol Interact 2014;220:200-7. doi: 10.1016/j.cbi.2014.06.027Search in Google Scholar

13. Ošiņa K, Rostoka E, Isajevs S, Sokolovska J, Sjakste T, Sjakste N. Effects of an antimutagenic 1,4-dihydropyridine AV-153 on expression of nitric oxide synthases and DNA repair-related enzymes and genes in kidneys of rats with a streptozotocin model of diabetes mellitus. Basic Clin Pharmacol Toxicol 2016;119:458-63. doi: 10.1111/bcpt.12617Search in Google Scholar

14. Ošiņa K, Rostoka E, Sokolovska J, Paramonova N, Bisenieks E, Duburs G, Sjakste N, Sjakste T. 1,4-Dihydropyridine derivatives without Ca2+-antagonist activity up-regulate Psma6 mRNA expression in kidneys of intact and diabetic rats. Cell Biochem Funct 2016;34:3-6. doi: 10.1002/cbf.3160Search in Google Scholar

15. Chen W, Feng L, Huang Z, Su H. Hispidin produced from Phellinus linteus protects against peroxynitrite-mediated DNA damage and hydroxyl radical generation. Chem Biol Interact 2012;199:137-42. doi: 10.1016/j.cbi.2012.07.001Search in Google Scholar

16. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, et al. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 2000;35:206-21. doi: 10.1002/(SICI)1098- 2280(2000)35:3<206::AID-EM8>3.0.CO;2-JSearch in Google Scholar

17. Olive PL, Banáth JP. The comet assay: a method to measure DNA damage in individual cells. Nat Protoc 2006;1:23-9. doi: 10.1038/nprot.2006.5Search in Google Scholar

18. Na N, Zhao DQ, Li H, Jiang N, Wen JY, Liu HY. DNA binding, photonuclease activity and human serum albumin interaction of a water-soluble freebase carboxyl corrole. Molecules. 2015;21(1):pii:E54. DOI: 10.3390/ molecules21010054.10.3390/21010054Open DOISearch in Google Scholar

19. Tsai YC, Wang YH, Liou CC, Lin YC, Huang H, Liu YC. Induction of oxidative DNA damage by flavonoids of propolis: its mechanism and implication about antioxidant capacity. Chem Res Toxicol 2012;25:191-6. doi: 10.1021/ tx200418kSearch in Google Scholar

20. Takahashi T, Harris RC. Role of endothelial nitric oxide synthase in diabetic nephropathy: lessons from diabetic eNOS knockout mice. J Diabetes Res 2014;2014:590541. doi: 10.1155/2014/590541Search in Google Scholar

21. Roe ND, Ren J. Nitric oxide synthase uncoupling: a therapeutic target in cardiovascular diseases. Vascul Pharmacol 2012;57:168-72. doi: 10.1016/j.vph.2012.02.004Search in Google Scholar

22. Liu B, Kuang L, Liu J. Bariatric surgery relieves type 2 diabetes and modulates inflammatory factors and coronary endothelium eNOS/iNOS expression in db/db mice. Can J Physiol Pharmacol 2014;92:70-7. doi: 10.1139/cjpp-2013- 0034Search in Google Scholar

23. Förstermann U, Li H. Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling. Br J Pharmacol 2011;164:213-23. doi: 10.1111/j.1476-5381.2010.01196.xSearch in Google Scholar

24. Perdomo L, Beneit N, Otero YF, Escribano Ó, Díaz- Castroverde S, Gómez-Hernández A, Benito M. Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process. Cardiovasc Diabetol 2015;14:75. doi: 10.1186/s12933-015-0237-9Search in Google Scholar

25. Mattila JT, Thomas AC. Nitric oxide synthase: non-canonical expression patterns. Front Immunol 2014;5:478. doi: 10.3389/fimmu.2014.00478Search in Google Scholar

26. Zhang L, Dong L, Liu X, Jiang Y, Zhang L, Zhang X, Li X, Zhang Y. α-Melanocyte-stimulating hormone protects retinal vascular endothelial cells from oxidative stress and apoptosis in a rat model of diabetes. PLoS One 2014;9:e93433. doi: 10.1371/journal.pone.0093433Search in Google Scholar

27. Chen YL, Chen KH, Yin TC, Huang TH, Yuen CM, Chung SY, Sung PH, Tong MS, Chen CH, Chang HW, Lin KC, Ko SF, Yip HK. Extracorporeal shock wave therapy effectively prevented diabetic neuropathy. Am J Transl Res 2015;7:2543-60. PMCID: PMC4731656Search in Google Scholar

28. Huang CC, Lai CJ, Tsai MH, Wu YC, Chen KT, Jou MJ, Fu PI, Wu CH, Wei IH, Effects of melatonin on the nitric oxide system and protein nitration in the hypobaric hypoxic rat hippocampus. BMC Neurosci 2015;16:61. doi: 10.1186/ s12868-015-0199-6Search in Google Scholar

29. Lu QB, Feng XM, Tong N, Sun HJ, Ding L, Wang YJ, Wang X, Zhou YB. Neuronal and endothelial nitric oxide synthases in the paraventricular nucleus modulate sympathetic overdrive in insulin-resistant rats. PLoS One 2015;10(10):e0140762. doi: 10.1371/journal.pone.0140762Search in Google Scholar

30. Heltianu C, Guja C. Role of nitric oxide synthase family in diabetic neuropathy. J Diabetes Metab 2011;S5:002. doi: 10.4172/2155-6156.S5-002Search in Google Scholar

31. Puthanveetil P, Zhang D, Wang Y, Wang F, Wan A, Abrahani A, Rodrigues B. Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1. J Mol Cell Cardiol 2012;53:677-86. doi: 10.1016/j. yjmcc.2012.08.013Search in Google Scholar

32. Martínez AC, Hernández M, Novella S, Martínez MP, Pagán RM, Hermenegildo C, García-Sacristán A, Prieto D, Benedito S. Diminished neurogenic femoral artery vasoconstrictor response in a Zucker obese rat model: differential regulation of NOS and COX derivatives. PLoS One 2014;9(9):e106372. doi: 10.1371/journal.pone.0106372 Search in Google Scholar

33. Ahad A, Mujeeb M, Ahsan H, Siddiqui WA. Prophylactic effect of baicalein against renal dysfunction in type 2 diabetic rats. Biochimie 2014;106:101-10. doi: 10.1016/j. biochi.2014.08.006Search in Google Scholar

34. Pautz A, Art J, Hahn S, Nowag S, Voss C, Kleinert H. Regulation of the expression of inducible nitric oxide synthase. Nitric Oxide 2010;23:75-93. doi: 10.1016/j. niox.2010.04.007Search in Google Scholar

35. Casper I, Nowag S, Koch K, Hubrich T, Bollmann F, Henke J, Schmitz K, Kleinert H, Pautz A. Post-transcriptional regulation of the human inducible nitric oxide synthase (iNOS) expression by the cytosolic poly(A)-binding protein (PABP). Nitric Oxide 2013;33:6-17. doi: 10.1016/j. niox.2013.05.002Search in Google Scholar

36. Perrotta I, Brunelli E, Sciangula A, Conforti F, Perrotta E, Tripepi S, Donato G, Cassese M. iNOS induction and PARP- 1 activation in human atherosclerotic lesions: an immunohistochemical and ultrastructural approach. Cardiovasc Pathol 2011;20:195-203. doi: 10.1016/j. carpath.2010.06.002Search in Google Scholar

37. Chen B, Lu Y, Chen Y, Cheng J. The role of Nrf2 in oxidative stress-induced endothelial injuries. J Endocrinol 2015;225:R83-99. doi: 10.1530/JOE-14-0662Search in Google Scholar

38. Kuo LJ, Yang LX. Gamma-H2AX - a novel biomarker for DNA double-strand breaks. In Vivo 2008;22:305-9. PMID: 18610740 Search in Google Scholar

39. Tchurikov NA, Yudkin DV, Gorbacheva MA, Kulemzina AI, Grischenko IV, Fedoseeva DM, Sosin DV, Kravatsky YV, Kretova OV. Hot spots of DNA double-strand breaks in human rDNA units are produced in vivo. Sci Rep 2016;6:25866. doi: 10.1038/srep25866Search in Google Scholar