Laryngeal cancer is the most common head and neck cancer. There might be many risk factors for laryngeal cancer. Smoking, especially cigarette smoking and alcohol are indisputable risk factors. The authors of this paper assessed the presumed risk factors in order to identify possible aetiological agents of the disease.
A hospital-based case-control study was conducted. The study group consisted of 108 histologically verified laryngeal cancer patients and 108 hospital controls matched by sex, age (±3 years) and place of residence. Laryngeal cancer patients and controls were interviewed during their hospital stay using a structured questionnaire. According to multiple logistic regression analysis six variables were independently related to laryngeal cancer: hard liquor consumption (Odd Ratio/OR/=2.93, Confidence Interval/CI/95% = 1.17 to 7.31), consumption more than 2 alcoholic drinks per day (OR=4.96, CI 95% = 2.04 to 12.04), cigarette smoking for more than 40 years (OR=4.32, CI 95% = 1.69 to 11.06), smoking more than 30 cigarettes per day (OR=4.24, CI 95% = 1.75 to 10.27), coffee consumption more than 5 cups per day (OR=4.52, CI 95% = 1.01 to 20.12) and carbonated beverage consumption (OR=0.38, CI 95%=0.16 to 0.92). The great majority of laryngeal cancers could be prevented by eliminating tobacco smoking and alcohol consumption.
Altieri A, Bosetti C, Talamini R, Gallus S, Franceschi S, Levi F, Dal Maso L, Negri E, La Vecchia C Cessation of smoking and drinking and the risk of laryngeal cancer. Br J Cancer 2002;87:1227-9.
Gallus S, Bosetti C, Franceschi S, Levi F, Negri E, La Vecchia C Laryngeal cancer in women: tobacco, alcohol, nutritional and hormonal factors. Cancer Epidemiol Biomarkers Prev 2003;12:514-7.
Saffiotti U, Kaufman DG Carcinogenesis of laryngeal carcinoma. Laryngoscope 1975;85:454-67.
Jaseviciene J, Gurevicius R, Juozulynas A, Cicenas S An evaluation of laryngeal cancer morbidity time trends in Lithuania. Rocz Akad Med Bialymst 2003;48:85-9.
Talamini R, Bosetti C, La Vecchia C, Dal Maso L, Levi F, Bidoli E, Negri E, Pasche C, Vaccarella S, Barzan L, Franceschi S Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study. Cancer Causes Control 2002;13:957-64.
Elci OC, Akpinar-Elci M, Blair A, Dosemeci M Risk of laryngeal cancer by occupational chemical exposure in Turkey. J Occup Environ Med 2003;45:1100-6.
Ha PK, Califano JA III. The molecular biology of laryngeal cancer. Otolaryngol Clin North Am 2002;35:993-1012.
Thekdi AA, Ferris RL Diagnostic assessment of laryngeal cancer. Otolaryngol Clin North Am 2002;35:953-69.
Wight R, Paleri V, Arullendran P Current theories for the development of nonsmoking and nondrinking laryngeal carcinoma. Curr Opin Otolaryngol Head Neck Surg 2003;11:73-7.
Sokic SI, Adanja BJ, Marinkovic JP, Vlajinac HD Case-control study of risk factors in laryngeal cancer. Neoplasma 1994;41:43-7.
Sokic SI, Adanja BJ, Marinkovic JP, Vlajinac HD Risk factors for laryngeal cancer. Eur J Epidemiol 1995;11:431-3.
Gustavsson P, Jakobsson R, Johansson H, Lewin F, Norell S, Rutkvist LE Occupational exposures and squamous cell carcinoma of the oral cavity, pharynx, larynx, and oesophagus: a case-control study in Sweden. Occup Environ Med 1998;55:393-400.
Berrino F, Richiardi L, Boffetta P, Esteve J, Belletti I, Raymond L, Troschel L, Pisani P, Zubiri L, Ascunce N, Gubéran E, Tuyns A, Terracini B, Merletti F Occupation and larynx and hypopharynx cancer: a job-exposure matrix approach in an international case-control study in France, Italy, Spain and Switzerland. Cancer Causes Control 2003;14:213-23.
Dietz A, Ramroth H, Urban T, Ahrens W, Becher H Exposure to cement dust, related occupational groups and laryngeal cancer risk: results of a population based case-control study. Int J Cancer 2004;108:907-11.
Boffetta P, Richiardi L, Berrino F, Esteve J, Pisani P, Crosignani P, Raymond L, Zubiri L, Del Moral A, Lehmann W, Donato F, Terracini B, Tuyns A, Merletti F Occupation and larynx and hypopharynx cancer: an international case-control study in France, Italy, Spain, and Switzerland. Cancer Causes Control 2003;14:203-12.
Bidoli E, Bosetti C, La Vecchia C, Levi F, Parpinel M, Talamini R, Negri E, Maso LD, Franceschi S Micronutrients and laryngeal cancer risk in Italy and Switzerland: a case-control study. Cancer Causes Control 2003;14:477-84.
American Joint Committee on Cancer (AJCC). Cancer Staging Manual. 6th ed. New York, Berlin, Heidelberg: Springer-Verlag; 2002.
Oreggia F, De Stefani E, Boffetta P, Brennan P, Deneo-Pellegrini H, Ronco AL Meat, fat and risk of laryngeal cancer: a case-control study in Uruguay. Oral Oncol 2001;37:141-5.
Pacella-Norman R, Urban MI, Sitas F, Carrara H, Sur R, Hale M, Ruff P, Patel M, Newton R, Bull D, Beral V Risk factors for oesophageal, lung, oral and laryngeal cancers in black South Africans. Br J Cancer 2002;86:1751-6.
Monteiro E, Varzim G, Pires AM, Teixeira M, Lopes C Cyclin D1 A870G polymorphism and amplification in laryngeal squamous cell carcinoma: implications of tumor localization and tobacco exposure. Cancer Detect Prev 2004;28:237-43.
Hashibe M, Boffetta P, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Mates D, Fabiánová E, Rudnai P, Brennan P Contribution of tobacco and alcohol to the high rates of squamous cell carcinoma of the supraglottis and glottis in Central Europe. Am J Epidemiol 2007;165:814-20.
Mendenhall WM, Million RR, Stringer SP, Cassisi NJ Squamous cell carcinoma of the glottic larynx: a review emphasizing the University of Florida philosophy. South Med J 1999;92:385-93.
Teppo H, Koivunen P, Sipila S, Jokinen K, Hyrynkangas K, Laara E, Pukkala E, Sovio U, Alho OP Decreasing incidence and improved survival of laryngeal cancer in Finland. Acta Oncol 2001;40:791-5.
Falk RT, Pickle LW, Brown LM, Mason TJ, Buffler PA, Fraumeni JF Jr. Effect of smoking and alcohol consumption on laryngeal cancer risk in coastal Texas. Cancer Res 1989;49:4024-9.
Homann N, Seitz KH Alcohol's effect on the development and progression of cancer. Nutr Clin Care 2000;3:83-6.
Garavello W, Bosetti C, Gallus S, Maso LD, Negri E, Franceschi S, La Vecchia C Type of alcoholic beverage and the risk of laryngeal cancer. Eur J Cancer Prev 2006;15:69-73.
Altieri A, Garavello W, Bosetti C, Gallus S, La Vecchia C Alcohol consumption and risk of laryngeal cancer. Oral Oncol 2005;41:956-65.
Bofetta P, Garfinkel L Alcohol drinking and mortality among men enrolled in an American Cancer Society prospective study. Epidemiol 1990;1:342-8.
Severi G, Plesko I, Robertson C, Obsitnikova A, Boyle P Larynx cancer in Slovakia and the role of anatomical subsites. Oral Oncol 1999;35:564-70.
Koskinen WJ, Brøndbo K, Mellin Dahlstrand H, Luostarinen T, Hakulinen T, Leivo I, Molijn A, Quint WG, Røysland T, Munck-Wikland E, Mäkitie AA, Pyykkö I, Dillner J, Vaheri A, Aaltonen LM Alcohol, smoking and human papillomavirus in laryngeal carcinoma: a Nordic prospective multicenter study. J Cancer Res Clin Oncol 2007;133:673-8.
Bosetti C, La Vecchia C, Talamini R, Negri E, Levi F, Dal Maso L, Franceschi S Food groups and laryngeal cancer risk: a case-control study from Italy and Switzerland. Int J Cancer 2002;100:355-60.
Bosetti C, La Vecchia C, Talamini R, Negri E, Levi F, Fryzek J, McLaughlin JK, Garavello W, Franceschi S Energy, macronutrients and laryngeal cancer risk. Ann Oncol 2003;14:907-12.
Tavani A, La Vecchia C Coffee and cancer: a review of epidemiological studies, 1990-1999. Eur J Cancer Prev 2000;9:241-56.
De Stefani E, Boffetta P, Deneo-Pellegrini H, Correa P, Ronco AL, Brennan P, Ferro G, Acosta G, Mendilaharsu M Non-alcoholic beverages and risk of bladder cancer in Uruguay. BMC Cancer 2007;7:57.
Larsson SC, Giovannucci E, Wolk A Coffee consumption and stomach cancer risk in a cohort of Swedish women. Int J Cancer 2006;119:2186-9.
Botelho F, Lunet N, Barros H Coffee and gastric cancer: systematic review and meta-analysis. Cad Saúde Pública 2006;22:889-900.
Koren R, Kristt D, Shvero J, Yaniv E, Dekel Y, Gal R The spectrum of laryngeal neoplasia: the pathologist's view. Pathol Res Pract 2002;198:709-15.
Makitie A, Pukander J, Raitiola H, Hyrynkangas K, Koivunen P, Virtaniemi J, Grenman R Changing trends in the occurrence and subsite distribution of laryngeal cancer in Finland. Eur Arch Otorhinolaryngol 1999;256:277-9.
Parkin DM, Pisani P, Ferlay J Global cancer statistics. CA Cancer J Clin 1999;49:33-64.
Carew JF, Shah JP Advances in multimodality therapy for laryngeal cancer. CA Cancer J Clin 1998;48:211-28.