Solubilisation of (+)-Usnic Acid in Aqueous Micellar Solutions of Gemini and Heterogemini Surfactants and their Equimolar Mixture

M. Lukáč 1 , I. Prokipčák 2 , I. Lacko 2 ,  and F. Devínsky 2
  • 1 Comenius University in Bratislava, Faculty of Pharmacy, Department of Chemical Theory of Drugs, Kalinčiakova 8, 832 32, Bratislava, Slovak Republic
  • 2 Comenius University in Bratislava, Faculty of Pharmacy, Department of Chemical Theory of Drugs


The solubilisation of natural compound, (+)-usnic acid, in micellar solutions of gemini (N,N’-didecyl-N,N,N’,N’-tetramethylethane-1,2-diyldiammonium dibromide) and heterogemini (decyl 2-[decyl(dimethyl)ammonio]ethylphosphate) surfactants and their equimolar mixture has been studied. The highest solubility was found for gemini surfactant. The relationship between synergism in surface properties of mixture of surfactants and their solubilisation properties is also discussed.

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