Synthesis and HPLC Enantioseparation of Derivatives of the 3-hydroxyphenylethanone

R. Čižmáriková 1 , A. Némethy 2 , J. Valentová 3 , K. Hroboňová 2 ,  and K. Bruchatá 3
  • 1 Comenius University in Bratislava, Faculty of Pharmacy,Department of Chemical Theory of Drugs, Odbojarov 10, 832 32 Bratislava, Slovak Republic
  • 2 Slovak University of Technology in Bratislava, Faculty of Chemical and Food technology, Institute of Analytical Chemistry
  • 3 Comenius University in Bratislava, Faculty of Pharmacy,Department of Chemical Theory of Drugs

Abstract

Within the framework of the study of the synthesis and high-performance liquid chromatography (HPLC) enantioseparation the series of 9 derivatives of 3-hydroxyphenylethanone was prepared by a well-tried method. The structure of the prepared compounds was confirmed on the basis of interpretation of the IR, UV, 1H NMR and 13C NMR spectra. An enantioseparation of prepared compounds was performed using HPLC on a native teicoplanin (Chirobiotic T) and the amylose tris (3,5-dimethylphenylcarbamate) (Chiralpak AD) chiral stationary phases, which is more suitable for the enantioseparation of all prepared compounds especially with heterocycles in the basic part of a molecule.

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