Synthesis and enantioseparation of derivatives of propranolol

R. Čižmáriková 1 , S. Chudáčiková 1 , J. Valentová 1 , and A. Némethy 1
  • 1 Faculty of Pharmacy, Department of Chemical Theory of Drugs, Comenius University in Bratislava

Synthesis and enantioseparation of derivatives of propranolol

Propranolol is one of the first prepared and in therapeutic praxis used beta- adrenolytics. In this paper novel derivatives of propranolol with cyclohexylamino and pyrrolidin-1-yl groups in hydrophilic part were prepared. HPLC-enantioseparation propranolol (as reference compound) and of the prepared derivatives has been achieved using a Chiralpak AD CSP based on the amylose tris (3,5-dimethylphenylcarbamate).(R)-enantiomer of the propranolol was prepared by stereoselective synthesis using Jacobsen catalyst.

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