A Rare Case of Primary Breast Mucosa- Associated Lymphoid Tissue Lymphoma

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Abstract

Breast involvement by lymphoma is uncommon and poses challenges in diagnosis. Breast involvement by malignant lymphoma, whether primary or secondary, is a rare event. Primary breast lymphomas account for 0.38% - 0.7% of all non-Hodgkin lymphomas, 1.7%-2.2% of all extranodal non-Hodgkin lymphomas, and only 0.04% - 0.5% of all breast cancer cases. Most frequent primary breast lymphomas are diffuse large B cell lymphomas (53%). Breast mucosa-associated lymphoid tissue (MALT) lymphomas account for a small fraction of all the MALT lymphomas (1% - 2%). Herein we report a case of a patient with primary breast MALT lymphoma and its presentation on different imaging modalities. Two years after the presentation and treatment with eight cycles of chemotherapy, the patient is alive and well, without evidence of residual disease or recurrence.

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  • 1. Avenia N S anguinetti A Cirocchi R et al. Primary breast lymphomas: a multicentric experience. World J Surg Oncol 2010; 8:53-6. https://doi.org/10.1186/1477-7819-8-53

  • 2. Jennings WC Baker RS Murray SS et al. Primary Breast Lymphoma. The Role of Mastectomy and the Importance of Lymph Node Status. Ann Surg 2007; 245:784-9. https://doi.org/10.1097/01.sla.0000254418.90192.59

  • 3. Uesato M M iyazawa Y G unji Y O chiai T . Primary Non-Hodgkin's lymphoma of the breast: report of a case with special reference to 380 cases in Japanese literature. Breast Cancer 2005; 12:154-8. https://doi.org/10.2325/jbcs.12.154

  • 4. Murata T Kuroda H Nakahama T et al. Primary non-Hodgkin malignant lymphoma of the male breast. Jpn J Clin Oncol 1996; 26:243-7. https://doi.org/10.1093/oxfordjournals.jjco.a023222

  • 5. Wiseman C Liao KT. Primary lymphoma of the breast. Cancer 1972; 29:1705-12. https://doi.org/10.1002/1097-0142(197206)29:6<1705::AIDCNCR2820290640>3.0.CO;2-I

  • 6. Hugh JC Jackson FI Hanson J Poppema S. Primary breast lymphoma. An immunohistologic study of 20 new cases. Cancer 1990; 66:2602-11. https://doi.org/10.1002/1097-0142(19901215)66:12<2602::AIDCNCR2820661224>3.0.CO;2-U

  • 7. Isaacson PG Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer 1983; 52:1410-6. https://doi.org/10.1002/1097-0142(19831015)52:8<1410::AIDCNCR2820520813>3.0.CO;2-3

  • 8. Gopal S Awasthi S Elghetany MT. Bilateral breast MALT lymphoma: a case report and review of the literature. Ann Hematol 2000; 79:86-9. https://doi.org/10.1007/s002770050016

  • 9. Lamovec J Jancar J. Primary malignant lymphoma o f t he b reast. L ymphoma o f t he mucosa-associated lymphoid tissue. Cancer 1987; 60:3033-41. https://doi.org/10.1002/1097-0142(19871215)60:12<3033::AIDCNCR2820601230>3.0.CO;2-A

  • 10. Mattia AR Ferry JA Harris NL. Breast lymphoma: a B -cell spectrum including lowgrade B-cell lymphoma of mucosa-associated lymphoid tissue. Am J Surg Pathol 1993; 17:574-87. https://doi.org/10.1097/00000478-199306000-00005

  • 11. Brogi E Harris N L. Lymphomas of the breast: pathology and clinical behavior. Semin Oncol 1999; 26:357-64.

  • 12. Arber DA Simpson JF Weiss LM Rappaport H. Non-Hodgkin's lymphoma involving the breast. Am J Surg Pathol 1994; 18:288-95. https://doi.org/10.1097/00000478-199403000-00009

  • 13. Sabate JM Gomez A Torrubia S et al. Lymphoma of the breast: clinical and radiologic features with pathologic correlation in 28 patients. Breast J 2002; 8:294-304 https://doi.org/10.1046/j.1524-4741.2002.08509.x

  • 14. Espinosa A L Daniel L B J effrey S S e t al. M RI of Mucosa-Associated Lymphoid Tissue Lymphoma. AJR 2005; 185:199-202. https://doi.org/10.2214/ajr.185.1.01850199

  • 15. Wong WW Schild SE Halyard MY Schomberg PJ. Primary non-Hodgkin lymphoma of the breast: the Mayo Clinic experience. J Surg Oncol 2002; 80:19-25. https://doi.org/10.1002/jso.10084

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