Beneficial effects of baicalein on a model of allergic rhinitis

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Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the in vivo protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology.

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  • 1. C. A. Tharpe and S. F. Kemp Pediatric allergic rhinitis Immunol. Allergy Clin. North Am. 35 (2015) 185–198;

  • 2. Y. K. Yanov S. V. Ryazantsev S. A. Artyushkin I. V. Fanta and S. S. Pavlova Allergic rhinitis: the modern aspects of therapy Vestn. Otorinolaringol. 83 (2018) 56–60;

  • 3. T. Ozdoganoglu M. Songu and H. M. Inancli Quality of life in allergic rhinitis Ther. Adv. Respir. Dis. 6 (2012) 25–39;

  • 4. P. W. Hellings and W. J. Fokkens Allergic rhinitis and its impact on otorhinolaryngology Allergy 61 (2006) 656–664;

  • 5. P. C. Bahekar J. H. Shah U. B. Ayer S. N. Mandhane and R. Thennati Validation of guinea pig model of allergic rhinitis by oral and topical drugs Int. Immunopharmacol. 8 (2008) 1540–1551;

  • 6. C. Cuppari S. Leonardi S. Manti M. Filippelli T. Alterio L. Spicuzza L. Rigoli T. Arrigo V. Lougaris and C. Salpietro Allergen immunotherapy routes of administration and cytokine networks: an update Immunotherapy 6 (2014) 775–786;

  • 7. T. T. Bui C. H. Piao C. H. Song and O. H. Chai Skullcapflavone II attenuates ovalbumin-induced allergic rhinitis through the blocking of Th2 cytokine production and mast cell histamine release Int. Immunopharmacol. 52 (2017) 77–84;

  • 8. P. C. Wei L. Tong and R. Li Effect of RORC inhibitor on HIF-1alpha and VEGF in nasal mucosa of allergic rhinitis of mice Chin. J. Otorhinolaryngol. Head Neck Surg. 53 (2018) 751–756;

  • 9. S. Qu T. Qin M. Li S. Zhang L. Ye J. Wei H. Fan and B. Chen The effects of resiquimod in an ovalbumin-induced allergic rhinitis model Int. Immunopharmacol. 59 (2018) 233–242;

  • 10. J. Yao D. Pan Y. Zhao L. Zhao J. Sun Y. Wang Q. D. You T. Xi Q. L. Guo and N. Lu Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway Immunology 143 (2014) 241–257;

  • 11. T. T. Bui C. H. Piao C. H. Song C. H. Lee H. S. Shin and O. H. Chai Baicalein wogonin and Scutellaria baicalensis ethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release Anat. Cell Biol. 50 (2017) 124–134;

  • 12. H. Yin L. Huang T. Ouyang and L. Chen Baicalein improves liver inflammation in diabetic db/db mice by regulating HMGB1/TLR4/NF-kappaB signaling pathway Int. Immunopharmacol. 55 (2018) 55–62;

  • 13. S. K. Ku and J. S. Bae Baicalin baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo BMB Rep. 48 (2015) 519–524;

  • 14. T. Hong G. B. Jin S. Cho and J. C. Cyong Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice Planta Med. 68 (2002) 268–271;

  • 15. X. Luo Z. Yu C. Deng J. Zhang G. Ren A. Sun S. Mani Z. Wang and W. Dou Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice Sci. Rep. 7 (2017) 16374;

  • 16. C. L. Tsai Y. C. Lin H. M. Wang and T. C. Chou Baicalein an active component of Scutellaria baicalensis protects against lipopolysaccharide-induced acute lung injury in rats J. Ethnopharmacol. 153 (2014) 197–206;

  • 17. Z. F. Li X. M. Xia C. Huang S. Zhang J. Zhang and A. J. Zhang Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis Hepatobiliary Pancreat. Dis. Int. 8 (2009) 201–208;

  • 18. H. G. Xin B. B. Zhang Z. Q. Wu X. F. Hang W. S. Xu W. Ni R. Q. Zhang and X. H. Miao Treatment with baicalein attenuates methionine-choline deficient diet-induced non-alcoholic steato-hepatitis in rats Eur. J. Pharmacol. 738 (2014) 310–318;

  • 19. J. Deng Y. Liu H. Lee A. Herrmann W. Zhang C. Zhang S. Shen S. J. Priceman M. Kujawski S. K. Pal A. Raubitschek D. S. Hoon S. Forman R. A. Figlin J. Liu R. Jove and H. Yu S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites Cancer Cell 21 (2012) 642–654;

  • 20. X. Yuan A. Ghosh Q. Jie G. He and Y. Wu Effects of desloratadine citrate disodium injection on rat models of ovalbumin-induced allergic rhinitis: involvement of T-cell responses modulation Int. Forum Allergy Rhinol. 5 (2015) 1170–1176;

  • 21. J. Bousquet R. Murray D. Price D. Somekh L. Munter J. Phillips and W. Czarlewski The allergic allergist behaves like a patient Ann. Allergy Asthma Immunol. 121 (2018) 741–742;

  • 22. X. L. Fan Q. X. Zeng X. Li C. L. Li Z. B. Xu X. Q. Deng J. Shi D. Chen S. G. Zheng and Q. L. Fu Induced pluripotent stem cell-derived mesenchymal stem cells activate quiescent T cells and elevate regulatory T cell response via NF-kappaB in allergic rhinitis patients Stem Cell Res. Ther. 9 (2018) 170;

  • 23. T. Iinuma Y. Okamoto Y. Morimoto T. Arai T. Sakurai S. Yonekura D. Sakurai K. Hirahara and T. Nakayama Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis Allergy 73 (2018) 479–489;

  • 24. F. Xu S. Yu M. Qin Y. Mao L. Jin N. Che S. Liu and R. Ge Hydrogen-rich saline ameliorates allergic rhinitis by reversing the imbalance of Th1/Th2 and up-regulation of CD4+CD25+ Foxp3+regulatory T cells interleukin-10 and membrane-bound transforming growth factor-beta in guinea pigs Inflammation 41 (2018) 81–92;

  • 25. A. M. Watts N. P. West A. W. Cripps P. K. Smith and A. J. Cox Distinct gene expression patterns between nasal mucosal cells and blood collected from allergic rhinitis sufferers Int. Arch. Allergy Immunol. 177 (2018) 29–34;

  • 26. M. O. Avincsal S. Ozbal A. O. Ikiz C. Pekcetin and E. A. Guneri Effects of topical intranasal doxycycline treatment in the rat allergic rhinitis model Clin. Exp. Otorhinolaryngol. 7 (2014) 106–111;

  • 27. X. Liu H. Hu H. Fan D. Zuo Z. Shou Y. Liao Z. Nan and Q. Tang The role of STAT3 and AhR in the differentiation of CD4+ T cells into Th17 and Treg cells Medicine (Baltimore) 96 (2017) e6615;

  • 28. Y. Ma X. Yuan L. Deng W. Xu Y. Zheng C. Yue G. Zhang F. Xie Y. H. Yang M. P. Gantier J. Liu D. Xu and L. Shen Imbalanced frequencies of Th17 and Treg cells in acute coronary syndromes are mediated by IL-6-STAT3 signaling PLoS One 8 (2013) e72804;

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