Antiproliferative evaluation of various aminoquinoline derivatives

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Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1af, primaquine bis-ureas 2af, chloroquine fumardiamides 3af and mefloquine fumardiamides 4af. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.

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